CysLT1
Cysteinyl leukotriene receptor 1 (CysLT1) é uma proteína que em humanos é codificada pelo gene CYSLTR1.[1]
Quando ocorre liberação de leucotrienos (LTC4, LTD4 e LTE4 - participantes das manifestações da asma brônquica), da cascata do ácido araquidônico, estes interagem com o receptor Cysteinyl leukotriene receptor 1, o que resulta em edema, inflamação de vias aéreas e broncoconstrição.[2]
Notas e referências
- ↑ Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF (1999). «Characterization of the human cysteinyl leukotriene CysLT1 receptor». Nature. 399 (6738): 789–93. PMID 10391245. doi:10.1038/21658
- ↑ SCHELLACK, Gustav. Farmacologia na prática clínica da área de saúde. São Paulo: Fundamento Educacional, 2006
Leitura de apoio[editar | editar código-fonte]
- Gronert K, Martinsson-Niskanen T, Ravasi S,; et al. (2001). «Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses.». Am. J. Pathol. 158 (1): 3–9. PMC 1850279
. PMID 11141472 - Sjöström M, Jakobsson PJ, Heimburger M,; et al. (2001). «Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.». Eur. J. Biochem. 268 (9): 2578–86. PMID 11322876. doi:10.1046/j.1432-1327.2001.02142.x
- Mellor EA, Maekawa A, Austen KF, Boyce JA (2001). «Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells.». Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7964–9. PMC 35451. PMID 11438743. doi:10.1073/pnas.141221498
- Mita H, Hasegawa M, Saito H, Akiyama K (2002). «Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils.». Clin. Exp. Allergy. 31 (11): 1714–23. PMID 11696047. doi:10.1046/j.1365-2222.2001.01184.x
- Shirasaki H, Kanaizumi E, Watanabe K,; et al. (2003). «Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa.». Clin. Exp. Allergy. 32 (7): 1007–12. PMID 12100046. doi:10.1046/j.1365-2222.2002.01425.x
- Ohshima N, Nagase H, Koshino T,; et al. (2002). «A functional study on CysLT(1) receptors in human eosinophils.». Int. Arch. Allergy Immunol. 129 (1): 67–75. PMID 12373000. doi:10.1159/000065175
- Strausberg RL, Feingold EA, Grouse LH,; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- Ohd JF, Nielsen CK, Campbell J,; et al. (2003). «Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas.». Gastroenterology. 124 (1): 57–70. PMID 12512030. doi:10.1053/gast.2003.50011
- Chibana K, Ishii Y, Asakura T, Fukuda T (2003). «Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin.». J. Immunol. 170 (8): 4290–5. PMID 12682264
- Espinosa K, Bossé Y, Stankova J, Rola-Pleszczynski M (2003). «CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4.». J. Allergy Clin. Immunol. 111 (5): 1032–40. PMID 12743568. doi:10.1067/mai.2003.1451
- Walch L, Norel X, Gascard JP, Brink C (2003). «Arachidonic acid inhibits cysteinyl-leukotriene receptor activation in human pulmonary vessels.». Adv. Exp. Med. Biol. 525: 75–9. PMID 12751740
- Nielsen CK, Ohd JF, Wikström K,; et al. (2003). «The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.». Adv. Exp. Med. Biol. 525: 201–4. PMID 12751768
- Mechiche H, Naline E, Candenas L,; et al. (2003). «Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites.». Clin. Exp. Allergy. 33 (7): 887–94. PMID 12859443. doi:10.1046/j.1365-2222.2003.01696.x
- Ota T, Suzuki Y, Nishikawa T,; et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
- Yang G, Haczku A, Chen H,; et al. (2004). «Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4.». Am. J. Physiol. Lung Cell Mol. Physiol. 286 (5): L992–1001. PMID 15064240. doi:10.1152/ajplung.00367.2003
- Gerhard DS, Wagner L, Feingold EA,; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- Naik S, Billington CK, Pascual RM,; et al. (2005). «Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling.». J. Biol. Chem. 280 (10): 8722–32. PMID 15590629. doi:10.1074/jbc.M413014200
- Corrigan C, Mallett K, Ying S,; et al. (2005). «Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis.». J. Allergy Clin. Immunol. 115 (2): 316–22. PMID 15696087. doi:10.1016/j.jaci.2004.10.051
Ligações externas[editar | editar código-fonte]
- «Leukotriene Receptors: CysLT1». IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology
