Bcl-2

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Família Bcl-2[1]

Bcl-2 refere-se a uma família de genes dos mamíferos e às proteínas a que estes genes dão origem. Estas regulam a permeabilidade da membrana externa da mitocôndria e podem ser, quer pró-apoptóticos (Bax, Bad, Bak e Bok, entre outros) quer anti-apoptóticos (Bcl-2 propriamente dito, Bcl-xL, e Bcl-w, entre outros). Há um total de 25 genes na família Bcl2-2 conhecidos até ao presente. A nome Bcl-2 deriva, do inglês, "B-cell lymphoma 2", "linfoma de células B 2", dado ser o segundo membro de um conjunto de proteínas inicialmente descritas como uma translocação genética recíproca no cromossoma 14 e 18 em linfomas foliculares.

Bcl-2 mostrou interações com RAD9A,[2] BAK1,[3] [4] Reticulon 4,[5] Bcl-2-associated X protein,[2] [3] [6] [7] Caspase 8,[8] [9] BECN1,[10] SOD1,[11] Bcl-2-interacting killer,[12] [13] BH3 interacting domain death agonist,[12] [14] RRAS,[15] C-Raf,[16] BCL2L11,[12] [17] [18] BNIPL,[19] [20] HRK,[12] [21] PSEN1,[22] BMF,[23] BNIP2,[19] [24] BNIP3,[24] [25] Nerve Growth factor IB,[3] BCL2-like 1,[3] [26] Myc,[27] BCAP31,[28] SMN1,[29] CAPN2,[30] PPP2CA,[31] Noxa,[12] [32] Cdk1,[33] [34] TP53BP2,[35] Bcl-2-associated death promoter[12] [36] e IRS1.[37]


Referências[editar | editar código-fonte]

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