COX-1

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Ciclo-oxigenase-1 (COX-1) também conhecida como prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 ou prostaglandin H2 synthase 1 é uma enzima que em humanos é codificada pelo gene PTGS1. É responsável pela catálise de prostaglandinas e tromboxano. Possui função fisiológica constitutiva e participa de uma série de processos de manutenção dos processos do organismo como a proteção da mucosa gástrica, hemostasia e regulação de perfusão renal.[1]

Notas e referências

  1. SCHELLACK, Gustav. Farmacologia na prática clínica da área de saúde. São Paulo: Fundamento Educacional, 2006

Leitura de apoio[editar | editar código-fonte]

  • Richards JA, Petrel TA, Brueggemeier RW. (2002). "Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells.". J. Steroid Biochem. Mol. Biol. 80 (2): 203–12 pp.. DOI:10.1016/S0960-0760(01)00187-X. PMID 11897504.
  • Jain S, Khuri FR, Shin DM. (2004). "Prevention of head and neck cancer: current status and future prospects.". Current problems in cancer 28 (5): 265–86 pp.. DOI:10.1016/j.currproblcancer.2004.05.003. PMID 15375804.
  • Bingham S, Beswick PJ, Blum DE, et al.. (2007). "The role of the cylooxygenase pathway in nociception and pain.". Semin. Cell Dev. Biol. 17 (5): 544–54 pp.. DOI:10.1016/j.semcdb.2006.09.001. PMID 17071117.
  • Diaz A, Reginato AM, Jimenez SA. (1992). "Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha.". J. Biol. Chem. 267 (15): 10816–22 pp.. PMID 1587858.
  • Takahashi Y, Ueda N, Yoshimoto T, et al.. (1992). "Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase).". Biochem. Biophys. Res. Commun. 182 (2): 433–8 pp.. DOI:10.1016/0006-291X(92)91750-K. PMID 1734857.
  • Vane JR, Mitchell JA, Appleton I, et al.. (1994). "Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.". Proc. Natl. Acad. Sci. U.S.A. 91 (6): 2046–50 pp.. DOI:10.1073/pnas.91.6.2046. PMID 7510883.
  • Mollace V, Colasanti M, Rodino P, et al.. (1994). "HIV coating gp 120 glycoprotein-dependent prostaglandin E2 release by human cultured astrocytoma cells is regulated by nitric oxide formation.". Biochem. Biophys. Res. Commun. 203 (1): 87–92 pp.. DOI:10.1006/bbrc.1994.2152. PMID 7521167.
  • Inoue H, Yokoyama C, Hara S, et al.. (1995). "Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element.". J. Biol. Chem. 270 (42): 24965–71 pp.. DOI:10.1074/jbc.270.42.24965. PMID 7559624.
  • Ren Y, Loose-Mitchell DS, Kulmacz RJ. (1995). "Prostaglandin H synthase-1: evaluation of C-terminus function.". Arch. Biochem. Biophys. 316 (2): 751–7 pp.. DOI:10.1006/abbi.1995.1100. PMID 7864630.
  • Picot D, Loll PJ, Garavito RM. (1994). "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.". Nature 367 (6460): 243–9 pp.. DOI:10.1038/367243a0. PMID 8121489.
  • Kosaka T, Miyata A, Ihara H, et al.. (1994). "Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2.". Eur. J. Biochem. 221 (3): 889–97 pp.. DOI:10.1111/j.1432-1033.1994.tb18804.x. PMID 8181472.
  • Otto JC, DeWitt DL, Smith WL. (1993). "N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.". J. Biol. Chem. 268 (24): 18234–42 pp.. PMID 8349699.
  • O'Neill GP, Ford-Hutchinson AW. (1993). "Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues.". FEBS Lett. 330 (2): 156–60 pp.. PMID 8365485.
  • Corasaniti MT, Melino G, Navarra M, et al.. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 4 (3): 315–21 pp.. PMID 8581564.
  • Ballif BA, Mincek NV, Barratt JT, et al.. (1996). "Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated protein.". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5544–9 pp.. DOI:10.1073/pnas.93.11.5544. PMID 8643612.
  • Hla T. (1996). "Molecular characterization of the 5.2 KB isoform of the human cyclooxygenase-1 transcript.". Prostaglandins 51 (1): 81–5 pp.. DOI:10.1016/0090-6980(95)00158-1. PMID 8900446.
  • Mahida YR, Beltinger J, Makh S, et al.. (1998). "Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2.". Am. J. Physiol. 273 (6 Pt 1): G1341–8 pp.. PMID 9435560.
  • Tsujii M, Kawano S, Tsuji S, et al.. (1998). "Cyclooxygenase regulates angiogenesis induced by colon cancer cells.". Cell 93 (5): 705–16 pp.. DOI:10.1016/S0092-8674(00)81433-6. PMID 9630216.

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