Globulina ligadora de hormônios sexuais

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A globulina ligadora de hormônios sexuais (SHBG, do inglês sex hormone-binding globulin) é uma glicoproteína que se liga aos hormônios sexuais, especificamente a testosterona e o estradiol. Estes dois hormônios circulam na corrente sanguínea ligados principalmente à SHBG e em algum grau à albumina.

Produção de SHBG[editar | editar código-fonte]

A SHBG é produzida pelas células do fígado e é lançada na corrente sanguínea. Outros locais que produzem a SHBG são o cérebro, útero e placenta. Além disso a SHBG é produzida pelos testículos; a SHBG produzida pelos testículos é também chamada de proteína ligadora de andrógenos. O gene para a SHBG está localizado no cromossomo 17.

Leitura de apoio[editar | editar código-fonte]

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  • Hryb DJ, Nakhla AM, Kahn SM, et al.. (2002). "Sex hormone-binding globulin in the human prostate is locally synthesized and may act as an autocrine/paracrine effector". J. Biol. Chem. 277 (29): 26618–22. DOI:10.1074/jbc.M202495200. PMID 12015315.
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  • Thompson DJ, Healey CS, Baynes C, Kalmyrzaev B, et al.. (2008). "Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women". Cancer Epidemiol Biomarkers Prev. 17 (12): 3490–8. DOI:10.1158/1055-9965.EPI-08-0734. PMID 19064566.