HMGA1

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HMGA1 (do inglês High mobility group AT-hook 1) é uma proteína que é codificada pelo gene humano HMGA1.[1] [2]

Este gene codifica uma proteína não-histónica envolvida em muitos processos celulares, incluindo a regulação de transcrição genética induzível, integração de retrovírus em cromossomas e a progressão de metástases.

A proteína codificada liga-se preferencialmente ao sulco menor de regiões ricas em A+T, em ADN de fita dupla. Tem pouca estrutura secundária em solução mas assume diferentes conformações quando ligada a substratos como ADN e outras proteínas.

A proteína codificada é frequentemente acetilada e encontrada no núcleo celular.[3]

Ratos que não possuem este gene desenvolvem um fenótipo de diabetes tipo 2.

Leitura adicional[editar | editar código-fonte]

  • Reeves R, Beckerbauer L. (2001). "HMGI/Y proteins: flexible regulators of transcription and chromatin structure.". Biochim. Biophys. Acta 1519 (1-2): 13–29. PMID 11406267.
  • Hui H, Perfetti R. (2002). "Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood.". Eur. J. Endocrinol. 146 (2): 129–41. DOI:10.1530/eje.0.1460129. PMID 11834421.
  • Van Maele B, Debyser Z. (2005). "HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins.". AIDS reviews 7 (1): 26–43. PMID 15875659.
  • Van Maele B, Busschots K, Vandekerckhove L, et al.. (2006). "Cellular co-factors of HIV-1 integration.". Trends Biochem. Sci. 31 (2): 98–105. DOI:10.1016/j.tibs.2005.12.002. PMID 16403635.
  • Reeves R, Nissen MS. (1990). "The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.". J. Biol. Chem. 265 (15): 8573–82. PMID 1692833.
  • Nissen MS, Langan TA, Reeves R. (1991). "Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein.". J. Biol. Chem. 266 (30): 19945–52. PMID 1939057.
  • Eckner R, Birnstiel ML. (1989). "Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif.". Nucleic Acids Res. 17 (15): 5947–59. DOI:10.1093/nar/17.15.5947. PMID 2505228.
  • Johnson KR, Lehn DA, Reeves R. (1989). "Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y.". Mol. Cell. Biol. 9 (5): 2114–23. PMID 2701943.
  • Palvimo J, Linnala-Kankkunen A. (1989). "Identification of sites on chromosomal protein HMG-I phosphorylated by casein kinase II.". FEBS Lett. 257 (1): 101–4. DOI:10.1016/0014-5793(89)81796-X. PMID 2806554.
  • Karlson JR, Mørk E, Holtlund J, et al.. (1989). "The amino acid sequence of the chromosomal protein HMG-Y, its relation to HMG-I and possible domains for the preferential binding of the proteins to stretches of A-T base pairs.". Biochem. Biophys. Res. Commun. 158 (3): 646–51. DOI:10.1016/0006-291X(89)92770-8. PMID 2920035.
  • Lund T, Dahl KH, Mørk E, et al.. (1987). "The human chromosomal protein HMG I contains two identical palindrome amino acid sequences.". Biochem. Biophys. Res. Commun. 146 (2): 725–30. DOI:10.1016/0006-291X(87)90589-4. PMID 3619901.
  • Leger H, Sock E, Renner K, et al.. (1995). "Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y.". Mol. Cell. Biol. 15 (7): 3738–47. PMID 7791781.
  • John S, Reeves RB, Lin JX, et al.. (1995). "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.". Mol. Cell. Biol. 15 (3): 1786–96. PMID 7862168.
  • Friedmann M, Holth LT, Zoghbi HY, Reeves R. (1993). "Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene.". Nucleic Acids Res. 21 (18): 4259–67. DOI:10.1093/nar/21.18.4259. PMID 8414980.
  • Farnet CM, Bushman FD. (1997). "HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro.". Cell 88 (4): 483–92. DOI:10.1016/S0092-8674(00)81888-7. PMID 9038339.
  • Miller MD, Farnet CM, Bushman FD. (1997). "Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition.". J. Virol. 71 (7): 5382–90. PMID 9188609.
  • Huth JR, Bewley CA, Nissen MS, et al.. (1997). "The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif.". Nat. Struct. Biol. 4 (8): 657–65. DOI:10.1038/nsb0897-657. PMID 9253416.
  • Currie RA. (1998). "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y).". J. Biol. Chem. 272 (49): 30880–8. DOI:10.1074/jbc.272.49.30880. PMID 9388234.
  • Chin MT, Pellacani A, Wang H, et al.. (1998). "Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y).". J. Biol. Chem. 273 (16): 9755–60. DOI:10.1074/jbc.273.16.9755. PMID 9545312.
  • Chiappetta G, Tallini G, De Biasio MC, et al.. (1998). "Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma.". Cancer Res. 58 (18): 4193–8. PMID 9751634.

Referências[editar | editar código-fonte]

  1. Friedmann M, Holth LT, Zoghbi HY, Reeves R. (Nov 1993). "Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene". Nucleic Acids Res 21 (18): 4259–67. DOI:10.1093/nar/21.18.4259. PMID 8414980.
  2. Reeves R, Beckerbauer L. (Jun 2001). "HMGI/Y proteins: flexible regulators of transcription and chromatin structure". Biochim Biophys Acta 1519 (1-2): 13–29. PMID 11406267.
  3. Entrez Gene: HMGA1 high mobility group AT-hook 1.

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