ORC5L

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Origin recognition complex, subunit 5-like (yeast)
Indicadores
Símbolo ORC5L
Entrez 5001
OMIM 602331
RefSeq NP_002544
UniProt O43913
Outros dados
Locus Cr. 7 [1]

Origin recognition complex, subunit 5-like (yeast) também conhecido como ORC5L, é uma proteína que em humanos é codificada pelo gene ORC5L.[1]

Interações[editar | editar código-fonte]

ORC5L mostrou interação com ORC1L,[2] ORC2L,[2] [3] [4] [5] MCM7,[2] ORC4L,[2] [3] [4] ORC3L,[2] [4] [6] [5] MCM2,[2] MCM4[2] e MCM3.[2]

Referências

  1. Entrez Gene: ORC5L origin recognition complex, subunit 5-like (yeast).
  2. a b c d e f g h Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich. (Mar. 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111-28. ISSN 0022-2836. PMID 12614612.
  3. a b Quintana, D G; Thome K C, Hou Z H, Ligon A H, Morton C C, Dutta A. (Oct. 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". J. Biol. Chem. 273 (42): 27137-45. ISSN 0021-9258. PMID 9765232.
  4. a b c Dhar, S K; Delmolino L, Dutta A. (Aug. 2001). "Architecture of the human origin recognition complex". J. Biol. Chem. 276 (31): 29067-71. DOI:10.1074/jbc.M103078200. ISSN 0021-9258. PMID 11395502.
  5. a b Vashee, S; Simancek P, Challberg M D, Kelly T J. (Jul. 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. 276 (28): 26666-73. DOI:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433.
  6. Pinto, S; Quintana D G, Smith P, Mihalek R M, Hou Z H, Boynton S, Jones C J, Hendricks M, Velinzon K, Wohlschlegel J A, Austin R J, Lane W S, Tully T, Dutta A. (May. 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron 23 (1): 45-54. ISSN 0896-6273. PMID 10402184.

Leitura de apoio[editar | editar código-fonte]

  • Maruyama K, Sugano S. (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Klemm RD, Austin RJ, Bell SP. (1997). "Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.". Cell 88 (4): 493–502. DOI:10.1016/S0092-8674(00)81889-9. PMID 9038340.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al.. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Ishiai M, Dean FB, Okumura K, et al.. (1998). "Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22.". Genomics 46 (2): 294–8. DOI:10.1006/geno.1997.5003. PMID 9417919.
  • Quintana DG, Thome KC, Hou ZH, et al.. (1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.". J. Biol. Chem. 273 (42): 27137–45. DOI:10.1074/jbc.273.42.27137. PMID 9765232.
  • Tugal T, Zou-Yang XH, Gavin K, et al.. (1999). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p.". J. Biol. Chem. 273 (49): 32421–9. DOI:10.1074/jbc.273.49.32421. PMID 9829972.
  • Jiang W, McDonald D, Hope TJ, Hunter T. (1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.". EMBO J. 18 (20): 5703–13. DOI:10.1093/emboj/18.20.5703. PMID 10523313.
  • Thome KC, Dhar SK, Quintana DG, et al.. (2001). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins.". J. Biol. Chem. 275 (45): 35233–41. DOI:10.1074/jbc.M005765200. PMID 10954718.
  • Vashee S, Simancek P, Challberg MD, Kelly TJ. (2001). "Assembly of the human origin recognition complex.". J. Biol. Chem. 276 (28): 26666–73. DOI:10.1074/jbc.M102493200. PMID 11323433.
  • Fröhling S, Nakabayashi K, Scherer SW, et al.. (2001). "Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22.". Hum. Genet. 108 (4): 304–9. DOI:10.1007/s004390100498. PMID 11379876.
  • Dhar SK, Delmolino L, Dutta A. (2001). "Architecture of the human origin recognition complex.". J. Biol. Chem. 276 (31): 29067–71. DOI:10.1074/jbc.M103078200. PMID 11395502.
  • Strausberg RL, Feingold EA, Grouse LH, et al.. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932.
  • Kneissl M, Pütter V, Szalay AA, Grummt F. (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.". J. Mol. Biol. 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. PMID 12614612.
  • Scherer SW, Cheung J, MacDonald JR, et al.. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMID 12690205.


  • Hillier LW, Fulton RS, Fulton LA, et al.. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
  • Ramachandran N, Hainsworth E, Bhullar B, et al.. (2004). "Self-assembling protein microarrays.". Science 305 (5680): 86–90. DOI:10.1126/science.1097639. PMID 15232106.
  • Gerhard DS, Wagner L, Feingold EA, et al.. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMID 15489334.



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