PPP2R1A

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PPP2R1A

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform é uma enzima que em humanos é codificada pelo gene PPP2R1A.[1]

Estudos do Centro para Câncer Johns Hopkins Kimmel publicados em setembro de 2010 na revista Science demonstraram que está relacionada com o câncer de ovário. Neste caso, sua falta pode fazer a célula sadia tornar-se cancerígena.[2]

Notas e referências

  1. Everett AD, Xue C, Stoops T. (August 1999). "Developmental expression of protein phosphatase 2A in the kidney". J. Am. Soc. Nephrol. 10 (8): 1737–45 pp.. PMID 10446941.
  2. G1. Estudo nos EUA identifica dois genes ligados ao câncer de ovário. Página visitada em 09/09/2010.

Leitura de apoio[editar | editar código-fonte]

  • Zolnierowicz S. (2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.". Biochem. Pharmacol. 60 (8): 1225–35 pp.. DOI:10.1016/S0006-2952(00)00424-X. PMID 11007961.
  • Walter G, Ruediger R, Slaughter C, Mumby M. (1990). "Association of protein phosphatase 2A with polyoma virus medium tumor antigen.". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2521–5 pp.. DOI:10.1073/pnas.87.7.2521. PMID 2157202.
  • Hemmings BA, Adams-Pearson C, Maurer F, et al.. (1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure.". Biochemistry 29 (13): 3166–73 pp.. DOI:10.1021/bi00465a002. PMID 2159327.
  • Walter G, Ferre F, Espiritu O, Carbone-Wiley A. (1989). "Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein.". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8669–72 pp.. DOI:10.1073/pnas.86.22.8669. PMID 2554323.
  • McCright B, Virshup DM. (1995). "Identification of a new family of protein phosphatase 2A regulatory subunits.". J. Biol. Chem. 270 (44): 26123–8 pp.. DOI:10.1074/jbc.270.44.26123. PMID 7592815.
  • Ruediger R, Hentz M, Fait J, et al.. (1994). "Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens.". J. Virol. 68 (1): 123–9 pp.. PMID 8254721.
  • Zolnierowicz S, Van Hoof C, Andjelković N, et al.. (1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.". Biochem. J. 317 ( Pt 1): 187–94 pp.. PMID 8694763.
  • Tung HY, De Rocquigny H, Zhao LJ, et al.. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.". FEBS Lett. 401 (2-3): 197–201 pp.. DOI:10.1016/S0014-5793(96)01470-6. PMID 9013886.
  • Ruediger R, Brewis N, Ohst K, Walter G. (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.". Virology 238 (2): 432–43 pp.. DOI:10.1006/viro.1997.8873. PMID 9400615.
  • Ruediger R, Fields K, Walter G. (1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens.". J. Virol. 73 (1): 839–42 pp.. PMID 9847399.
  • Groves MR, Hanlon N, Turowski P, et al.. (1999). "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.". Cell 96 (1): 99–110 pp.. DOI:10.1016/S0092-8674(00)80963-0. PMID 9989501.
  • Hong Y, Sarge KD. (1999). "Regulation of protein phosphatase 2A activity by heat shock transcription factor 2.". J. Biol. Chem. 274 (19): 12967–70 pp.. DOI:10.1074/jbc.274.19.12967. PMID 10224043.
  • Yan Z, Fedorov SA, Mumby MC, Williams RS. (2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells.". Mol. Cell. Biol. 20 (3): 1021–9 pp.. DOI:10.1128/MCB.20.3.1021-1029.2000. PMID 10629059.
  • Husi H, Ward MA, Choudhary JS, et al.. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661–9 pp.. DOI:10.1038/76615. PMID 10862698.
  • Hrimech M, Yao XJ, Branton PE, Cohen EA. (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.". EMBO J. 19 (15): 3956–67 pp.. DOI:10.1093/emboj/19.15.3956. PMID 10921877.
  • Ruteshouser EC, Ashworth LK, Huff V. (2001). "Absence of PPP2R1A mutations in Wilms tumor.". Oncogene 20 (16): 2050–4 pp.. DOI:10.1038/sj.onc.1204301. PMID 11360189.
  • Lubert EJ, Hong Y, Sarge KD. (2001). "Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5.". J. Biol. Chem. 276 (42): 38582–7 pp.. DOI:10.1074/jbc.M106906200. PMID 11504734.
  • Elder RT, Yu M, Chen M, et al.. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.". Virology 287 (2): 359–70 pp.. DOI:10.1006/viro.2001.1007. PMID 11531413.
  • Li X, Virshup DM. (2002). "Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.". Eur. J. Biochem. 269 (2): 546–52 pp.. DOI:10.1046/j.0014-2956.2001.02680.x. PMID 11856313.

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