Predefinição:PBB/596

B-cell CLL/lymphoma 2
Renderização PDB baseada em 1GJH,1G5M.
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN
Identificadores
Símbolos	BCL2; Bcl-2; PPP1R50
IDs externos	OMIM: 151430 MGI: 88138 HomoloGene: 527 ChEMBL: 4860 GeneCards: BCL2 Gene
Ontologia do gene Função molecular •protease binding •protein binding •transcription factor binding •channel activity •channel inhibitor activity •ubiquitin protein ligase binding •identical protein binding •protein homodimerization activity •sequence-specific DNA binding •protein heterodimerization activity •BH3 domain binding •protein phosphatase 2A binding Componente celular •nucleus •cytoplasm •mitochondrion •mitochondrial outer membrane •endoplasmic reticulum •endoplasmic reticulum membrane •cytosol •membrane •nuclear membrane •myelin sheath •pore complex Processo biológico •protein polyubiquitination •response to acid •ossification •ovarian follicle development •metanephros development •branching involved in ureteric bud morphogenesis •behavioral fear response •B cell homeostasis •release of cytochrome c from mitochondria •regulation of cell-matrix adhesion •lymphoid progenitor cell differentiation •B cell lineage commitment •response to ischemia •renal system process •protein dephosphorylation •melanin metabolic process •regulation of nitrogen utilization •apoptotic process •humoral immune response •cellular response to DNA damage stimulus •actin filament organization •axonogenesis •female pregnancy •cell aging •male gonad development •extrinsic apoptotic signaling pathway via death domain receptors •intrinsic apoptotic signaling pathway in response to DNA damage •intrinsic apoptotic signaling pathway in response to oxidative stress •response to radiation •response to toxic substance •post-embryonic development •response to iron ion •response to UV-B •response to gamma radiation •negative regulation of autophagy •negative regulation of calcium ion transport into cytosol •regulation of glycoprotein biosynthetic process •mesenchymal cell development •positive regulation of neuron maturation •positive regulation of smooth muscle cell migration •cell growth •single organismal cell-cell adhesion •peptidyl-serine phosphorylation •peptidyl-threonine phosphorylation •cochlear nucleus development •gland morphogenesis •regulation of transmembrane transporter activity •negative regulation of ossification •positive regulation of cell growth •negative regulation of cell growth •melanocyte differentiation •negative regulation of cell migration •positive regulation of B cell proliferation •hair follicle morphogenesis •axon regeneration •regulation of protein stability •endoplasmic reticulum calcium ion homeostasis •glomerulus development •negative regulation of cellular pH reduction •negative regulation of myeloid cell apoptotic process •T cell differentiation in thymus •positive regulation of peptidyl-serine phosphorylation •negative regulation of osteoblast proliferation •response to cytokine •response to nicotine •organ growth •nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway •positive regulation of multicellular organism growth •B cell proliferation •cellular response to glucose starvation •response to drug •response to hydrogen peroxide •T cell homeostasis •negative regulation of apoptotic process •positive regulation of catalytic activity •CD8-positive, alpha-beta T cell lineage commitment •regulation of protein homodimerization activity •regulation of protein heterodimerization activity •negative regulation of neuron apoptotic process •ear development •regulation of viral genome replication •innate immune response •positive regulation of melanocyte differentiation •negative regulation of mitotic cell cycle •negative regulation of retinal cell programmed cell death •regulation of mitochondrial membrane permeability •focal adhesion assembly •spleen development •thymus development •digestive tract morphogenesis •developmental growth •oocyte development •positive regulation of skeletal muscle fiber development •pigment granule organization •homeostasis of number of cells within a tissue •B cell receptor signaling pathway •response to glucocorticoid •neuron apoptotic process •defense response to virus •regulation of mitochondrial membrane potential •negative regulation of mitochondrial depolarization •regulation of calcium ion transport •transmembrane transport •intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress •cellular response to organic substance •cellular response to hypoxia •reactive oxygen species metabolic process •extrinsic apoptotic signaling pathway in absence of ligand •intrinsic apoptotic signaling pathway •positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway •negative regulation of G1/S transition of mitotic cell cycle •negative regulation of anoikis •negative regulation of apoptotic signaling pathway •negative regulation of extrinsic apoptotic signaling pathway in absence of ligand •negative regulation of intrinsic apoptotic signaling pathway •positive regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies	Humano	Rato
Entrez	596	12043
Ensembl	ENSG00000171791	ENSMUSG00000057329
UniProt	P10415	P10417
RefSeq (mRNA)	NM_000633	NM_009741
RefSeq (proteína)	NP_000624	NP_033871
Localização (UCSC)	Chr 18: 60.79 – 60.99 Mb	Chr 1: 106.54 – 106.71 Mb
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