VAV3

Origem: Wikipédia, a enciclopédia livre.
Ir para: navegação, pesquisa
Vav 3 oncogene
Indicadores
Símbolo VAV3
Símbolos alt. FLJ40431
HUGO 12659
Entrez 10451
OMIM 605541
RefSeq NP_001073343
UniProt Q9UKW4
Outros dados
Locus Cr. 1 [1]

Vav 3 oncogene, também conhecido como VAV3, é uma proteína que em humanos é codificado pelo gene VAV3.[1]

Interações[editar | editar código-fonte]

VAV3 mostrou interação com a Grb2.[2] [3]

Referências

  1. Entrez Gene: VAV3 vav 3 oncogene.
  2. Blagoev, Blagoy; Kratchmarova Irina, Ong Shao-En, Nielsen Mogens, Foster Leonard J, Mann Matthias. (Mar. 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315-8. DOI:10.1038/nbt790. ISSN 1087-0156. PMID 12577067.
  3. Zeng, L; Sachdev P, Yan L, Chan J L, Trenkle T, McClelland M, Welsh J, Wang L H. (Dec. 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212-24. ISSN 0270-7306. PMID 11094073.

Leitura de apoio[editar | editar código-fonte]

  • Hobert O, Schilling JW, Beckerle MC, et al.. (1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin.". Oncogene 12 (7): 1577–81. PMID 8622875.
  • Tamma SM, Chirmule N, Yagura H, et al.. (1997). "CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.". Blood 90 (4): 1588–93. PMID 9269777.
  • Trenkle T, Welsh J, Jung B, et al.. (1998). "Non-stoichiometric reduced complexity probes for cDNA arrays.". Nucleic Acids Res. 26 (17): 3883–91. DOI:10.1093/nar/26.17.3883. PMID 9705494.
  • Movilla N, Bustelo XR. (1999). "Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins.". Mol. Cell. Biol. 19 (11): 7870–85. PMID 10523675.
  • Trenkle T, McClelland M, Adlkofer K, Welsh J. (2000). "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors.". Gene 245 (1): 139–49. DOI:10.1016/S0378-1119(00)00026-3. PMID 10713454.
  • Zeng L, Sachdev P, Yan L, et al.. (2001). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.". Mol. Cell. Biol. 20 (24): 9212–24. DOI:10.1128/MCB.20.24.9212-9224.2000. PMID 11094073.
  • Inabe K, Ishiai M, Scharenberg AM, et al.. (2002). "Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation.". J. Exp. Med. 195 (2): 189–200. DOI:10.1084/jem.20011571. PMID 11805146.
  • Yabana N, Shibuya M. (2002). "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.". Oncogene 21 (50): 7720–9. DOI:10.1038/sj.onc.1205927. PMID 12400014.
  • Ota T, Suzuki Y, Nishikawa T, et al.. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
  • Zakaria S, Gomez TS, Savoy DN, et al.. (2004). "Differential regulation of TCR-mediated gene transcription by Vav family members.". J. Exp. Med. 199 (3): 429–34. DOI:10.1084/jem.20031228. PMID 14757747.
  • Pearce AC, Senis YA, Billadeau DD, et al.. (2005). "Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.". J. Biol. Chem. 279 (52): 53955–62. DOI:10.1074/jbc.M410355200. PMID 15456756.
  • Charvet C, Canonigo AJ, Billadeau DD, Altman A. (2005). "Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.". J. Biol. Chem. 280 (15): 15289–99. DOI:10.1074/jbc.M500275200. PMID 15708849.
  • Lyons LS, Burnstein KL. (2006). "Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity.". Mol. Endocrinol. 20 (5): 1061–72. DOI:10.1210/me.2005-0346. PMID 16384856.
  • Dong Z, Liu Y, Lu S, et al.. (2006). "Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer.". Mol. Endocrinol. 20 (10): 2315–25. DOI:10.1210/me.2006-0048. PMID 16762975.
Ícone de esboço Este artigo sobre proteínas é um esboço. Você pode ajudar a Wikipédia expandindo-o.