BRCA1

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Breast cancer 1, early onset
Renderização PDB baseada em 1jm7.
Estruturas disponíveis
PDB Busca de ortólogos: PDBe, RCSB
Identificadores
Símbolos BRCA1; BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PPP1R53; PSCP; RNF53
IDs externos OMIM: 113705 MGI104537 HomoloGene5276 ChEMBL: 5990 GeneCards: BRCA1 Gene
Padrões de expressão do ARN
PBB GE BRCA1 204531 s at.png
PBB GE BRCA1 211851 x at.png
Mais dados de expressão
Ortólogos
Espécies Humano Rato
Entrez 672 12189
Ensembl ENSG00000012048 ENSMUSG00000017146
UniProt P38398 P48754
RefSeq (mRNA) NM_007294 NM_009764
RefSeq (proteína) NP_009225 NP_033894
Localização (UCSC) Chr 17:
41.2 – 41.28 Mb
Chr 11:
101.49 – 101.55 Mb
Busca PubMed [1] [2]

BRCA1 (breast cancer 1, early onset) é um gene humano que pertence à classe de genes conhecida como genes supressores de tumor, que regula o ciclo celular e previnem a proliferação descontrolada.

Algumas variações do BRCA1 levam ao risco aumentado de câncer de mama.

Interações[editar | editar código-fonte]

O BRCA1 mostrou interação com:

Ver também[editar | editar código-fonte]

Referências

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Leitura de apoio[editar | editar código-fonte]

  • Cui JQ, Wang H, Reddy ES, Rao VN (1998). «Differential transcriptional activation by the N-terminal region of BRCA1 splice variants BRCA1a and BRCA1b». Oncology reports [S.l.: s.n.] 5 (3): 585–9. PMID 9538156. 
  • Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN (1997). «BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases». Oncogene [S.l.: s.n.] 15 (2): 143–57. doi:10.1038/sj.onc.1201252. PMID 9244350.  Parâmetro desconhecido |month= ignorado (|data=) (Ajuda)
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