Bcl-2

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B-cell CLL/lymphoma 2
Renderização PDB baseada em 1GJH,1G5M.
Estruturas disponíveis
PDB Busca de ortólogos: PDBe, RCSB
Identificadores
Símbolos BCL2; Bcl-2; PPP1R50
IDs externos OMIM: 151430 MGI88138 HomoloGene527 ChEMBL: 4860 GeneCards: BCL2 Gene
Padrões de expressão do ARN
PBB GE BCL2 203685 at.png
PBB GE BCL2 203684 s at.png
PBB GE BCL2 207005 s at.png
Mais dados de expressão
Ortólogos
Espécies Humano Rato
Entrez 596 12043
Ensembl ENSG00000171791 ENSMUSG00000057329
UniProt P10415 P10417
RefSeq (mRNA) NM_000633 NM_009741
RefSeq (proteína) NP_000624 NP_033871
Localização (UCSC) Chr 18:
60.79 – 60.99 Mb
Chr 1:
106.54 – 106.71 Mb
Busca PubMed [1] [2]
Família Bcl-2[1]

Bcl-2 refere-se a uma família de genes dos mamíferos e às proteínas a que estes genes dão origem. Estas regulam a permeabilidade da membrana externa da mitocôndria e podem ser, quer pró-apoptóticos (Bax, Bad, Bak e Bok, entre outros) quer anti-apoptóticos (Bcl-2 propriamente dito, Bcl-xL, e Bcl-w, entre outros). Há um total de 25 genes na família Bcl2-2 conhecidos até ao presente. A nome Bcl-2 deriva, do inglês, "B-cell lymphoma 2", "linfoma de células B 2", dado ser o segundo membro de um conjunto de proteínas inicialmente descritas como uma translocação genética recíproca no cromossoma 14 e 18 em linfomas foliculares.

Bcl-2 mostrou interações com RAD9A,[2] BAK1,[3] [4] Reticulon 4,[5] Bcl-2-associated X protein,[2] [3] [6] [7] Caspase 8,[8] [9] BECN1,[10] SOD1,[11] Bcl-2-interacting killer,[12] [13] BH3 interacting domain death agonist,[12] [14] RRAS,[15] C-Raf,[16] BCL2L11,[12] [17] [18] BNIPL,[19] [20] HRK,[12] [21] PSEN1,[22] BMF,[23] BNIP2,[19] [24] BNIP3,[24] [25] Nerve Growth factor IB,[3] BCL2-like 1,[3] [26] Myc,[27] BCAP31,[28] SMN1,[29] CAPN2,[30] PPP2CA,[31] Noxa,[12] [32] Cdk1,[33] [34] TP53BP2,[35] Bcl-2-associated death promoter[12] [36] e IRS1.[37]


Referências[editar | editar código-fonte]

  1. Chao DT, Korsmeyer SJ. BCL-2 family: regulators of cell death. Annu Rev Immunol. 1998;16:395-419. Review.
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  14. Real, Pedro Jose; Cao Yeyu, Wang Renxiao, Nikolovska-Coleska Zaneta, Sanz-Ortiz Jaime, Wang Shaomeng, Fernandez-Luna Jose Luis (2004). «Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2». Cancer Res. (United States [s.n.]) 64 (21): 7947–53. doi:10.1158/0008-5472.CAN-04-0945. ISSN 0008-5472. PMID 15520201. 
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  18. Hsu, S Y; Lin P, Hsueh A J (1998). «BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members». Mol. Endocrinol. (UNITED STATES [s.n.]) 12 (9): 1432–40. doi:10.1210/me.12.9.1432. ISSN 0888-8809. PMID 9731710. 
  19. a b Qin, Wenxin; Hu Jian, Guo Minglei, Xu Jian, Li Jinjun, Yao Genfu, Zhou Xiaomei, Jiang Huiqiu, Zhang Pingping, Shen Li, Wan Dafang, Gu Jianren (2003). «BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis». Biochem. Biophys. Res. Commun. (United States [s.n.]) 308 (2): 379–85. doi:10.1016/S0006-291X(03)01387-1. ISSN 0006-291X. PMID 12901880. 
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  24. a b Boyd, J M; Malstrom S, Subramanian T, Venkatesh L K, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G (1994). «Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins». Cell (UNITED STATES [s.n.]) 79 (2): 341–51. doi:10.1016/0092-8674(94)90202-X. ISSN 0092-8674. PMID 7954800. 
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  32. Oda, E; Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (2000). «Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis». Science (UNITED STATES [s.n.]) 288 (5468): 1053–8. doi:10.1126/science.288.5468.1053. ISSN 0036-8075. PMID 10807576. 
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  37. Ueno, H; Kondo E, Yamamoto-Honda R, Tobe K, Nakamoto T, Sasaki K, Mitani K, Furusaka A, Tanaka T, Tsujimoto Y, Kadowaki T, Hirai H (2000). «Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function». Mol. Biol. Cell (UNITED STATES [s.n.]) 11 (2): 735–46. ISSN 1059-1524. PMC 14806. PMID 10679027.