GRB2

Origem: Wikipédia, a enciclopédia livre.
Growth factor receptor-bound protein 2
GRB2
Indicadores
Símbolo Grb2
Símbolos alt. ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084
Entrez 2885
OMIM 108355
RefSeq NP_002077
UniProt P62993
Outros dados
Locus Cr. 17 [1]

Growth factor receptor-bound protein 2 também conhecido como Grb2 é uma proteína adptadora envolvida na transdução de sinal/sinalização celular. Nos humanos a proteína GRB2 é codificada pelo gene GRB2.[1][2]

Interações[editar | editar código-fonte]

Grb2 mostrou interação com Arachidonate 5-lipoxygenase,[3][4] Lymphocyte cytosolic protein 2,[5][6][7][8][9] GAB2,[10][11][12] B-cell linker,[13][14][15][16] Abl gene,[17][18] CD28,[19][20] FRS2,[21][22][23][24] Mitogen-activated protein kinase 9,[25][26] CD22,[27][28] NEU3,[29] ETV6,[10] MAP2,[30][31] Dock180,[32][33] PIK3R1,[34][35] SH2B1,[36][37] CRK,[38][39][40] GAB1,[5][41][42] MST1R,[43][44] DNM1,[45][46] Huntingtin,[47] Src,[48][49] Beta-2 adrenergic receptor,[50] VAV2,[51][52] ADAM15,[53] RAPGEF1,[54][55] VAV1,[56][57][58][59] HER2/neu,[52][60][61] Epidermal growth factor receptor,[2][41][51][60][62][63][64][65][66][67] PDGFRB,[67][68][69] PTK2,[70][71][72][73][74] Erythropoietin receptor,[75][76] Linker of activated T cells,[77][78][79] Dystroglycan,[80] SH3KBP1,[81][82] Granulocyte colony-stimulating factor receptor,[83] DCTN1,[84] CDKN1B,[85] Colony stimulating factor 1 receptor,[86] EPH receptor A2,[87] KHDRBS1,[41][88][89] RET proto-oncogene,[90][91] PLCG1,[92][93][94] TrkA,[95][96] PRKAR1A,[64] Janus kinase 2,[97][98] MUC1,[99] CD117,[76][100][101] Fas ligand,[102][103] Janus kinase 1,[98][104] VAV3,[51][105] BCAR1,[71][106] PTPN1,[107][108] INPP5D,[109] ITK,[110][111] SHC1,[49][51][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130] PTPN12,[131] C-Met,[132][133] PTPN11,[69][83][125][134][135][136][137][138][139] Glycoprotein 130,[59] PTPN6,[49][134][140] Syk,[49][134] MAP4K1,[141][142][143][144] Wiskott-Aldrich syndrome protein,[145][146] NCKIPSD,[147][148] PTPRA,[149][150][151] BCR gene,[10][113][152][153][154][155] CBLB,[156][157][158] Cbl gene,[7][22][49][88][122][156][159][160][161][162][163][164][165] SOS1,[6][22][40][41][46][49][51][58][66][88][93][99][113][120][122][129][166][167][168][169][170] IRS1,[98][112][171] TNK2,[114][172] MED28,[173] MAP3K1[174] e HNRNPC.[175]

Referências

  1. ↑ Matuoka K, Shibata M, Yamakawa A, Takenawa T (outubro de 1992). «Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries». Proc. Natl. Acad. Sci. U.S.A. 89 (19): 9015–9. PMC 50055Acessível livremente. PMID 1384039. doi:10.1073/pnas.89.19.9015 
  2. ↑ a b Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J (agosto de 1992). «The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling». Cell. 70 (3): 431–42. PMID 1322798. doi:10.1016/0092-8674(92)90167-B 
  3. ↑ VanderNoot, V A; Fitzpatrick F A (setembro de 1995). «Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding protein 2». UNITED STATES. Anal. Biochem. 230 (1): 108–14. ISSN 0003-2697. PMID 8585605. doi:10.1006/abio.1995.1444 
  4. ↑ Lepley, R A; Fitzpatrick F A (setembro de 1994). «5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins». UNITED STATES. J. Biol. Chem. 269 (39): 24163–8. ISSN 0021-9258. PMID 7929073 
  5. ↑ a b Lewitzky, M; Kardinal C, Gehring N H, Schmidt E K, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller S M (março de 2001). «The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif». England. Oncogene. 20 (9): 1052–62. ISSN 0950-9232. PMID 11314042. doi:10.1038/sj.onc.1204202 
  6. ↑ a b Robinson, A; Gibbins J, Rodríguez-Liñares B, Finan P M, Wilson L, Kellie S, Findell P, Watson S P (julho de 1996). «Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking». UNITED STATES. Blood. 88 (2): 522–30. ISSN 0006-4971. PMID 8695800 
  7. ↑ a b Erdreich-Epstein, A; Liu M, Kant A M, Izadi K D, Nolta J A, Durden D L (abril de 1999). «Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages». UNITED STATES. J. Leukoc. Biol. 65 (4): 523–34. ISSN 0741-5400. PMID 10204582 
  8. ↑ Hendricks-Taylor, L R; Motto D G, Zhang J, Siraganian R P, Koretzky G A (janeiro de 1997). «SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells». UNITED STATES. J. Biol. Chem. 272 (2): 1363–7. ISSN 0021-9258. PMID 8995445. doi:10.1074/jbc.272.2.1363 
  9. ↑ Asada, H; Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K (maio de 1999). «Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT». UNITED STATES. J. Exp. Med. 189 (9): 1383–90. ISSN 0022-1007. PMID 10224278. doi:10.1084/jem.189.9.1383 
  10. ↑ a b c Million, Ryan P; Harakawa Nari, Roumiantsev Sergei, Varticovski Lyuba, Van Etten Richard A (junho de 2004). «A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase». United States. Mol. Cell. Biol. 24 (11): 4685–95. ISSN 0270-7306. PMID 15143164. doi:10.1128/MCB.24.11.4685-4695.2004 
  11. ↑ Lynch, Danielle K; Daly Roger J (janeiro de 2002). «PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2». England. EMBO J. 21 (1-2): 72–82. ISSN 0261-4189. PMID 11782427. doi:10.1093/emboj/21.1.72 
  12. ↑ Zhao, C; Yu D H, Shen R, Feng G S (julho de 1999). «Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1». UNITED STATES. J. Biol. Chem. 274 (28): 19649–54. ISSN 0021-9258. PMID 10391903. doi:10.1074/jbc.274.28.19649 
  13. ↑ Fu, C; Turck C W, Kurosaki T, Chan A C (julho de 1998). «BLNK: a central linker protein in B cell activation». UNITED STATES. Immunity. 9 (1): 93–103. ISSN 1074-7613. PMID 9697839. doi:10.1016/S1074-7613(00)80591-9 
  14. ↑ Engels, N; Wollscheid B, Wienands J (julho de 2001). «Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha». Germany. Eur. J. Immunol. 31 (7): 2126–34. ISSN 0014-2980. PMID 11449366. doi:10.1002/1521-4141(200107)31:7<2126::AID-IMMU2126>3.0.CO;2-O 
  15. ↑ Fusaki, N; Tomita S, Wu Y, Okamoto N, Goitsuka R, Kitamura D, Hozumi N (maio de 2000). «BLNK is associated with the CD72/SHP-1/Grb2 complex in the WEHI231 cell line after membrane IgM cross-linking». GERMANY. Eur. J. Immunol. 30 (5): 1326–30. ISSN 0014-2980. PMID 10820378. doi:10.1002/(SICI)1521-4141(200005)30:5<1326::AID-IMMU1326>3.0.CO;2-Q 
  16. ↑ Wienands, J; Schweikert J, Wollscheid B, Jumaa H, Nielsen P J, Reth M (agosto de 1998). «SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation». UNITED STATES. J. Exp. Med. 188 (4): 791–5. ISSN 0022-1007. PMID 9705962. doi:10.1084/jem.188.4.791 
  17. ↑ Warmuth, M; Bergmann M, Priess A, Häuslmann K, Emmerich B, Hallek M (dezembro de 1997). «The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr». UNITED STATES. J. Biol. Chem. 272 (52): 33260–70. ISSN 0021-9258. PMID 9407116. doi:10.1074/jbc.272.52.33260 
  18. ↑ Ren, R; Ye Z S, Baltimore D (abril de 1994). «Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites». UNITED STATES. Genes Dev. 8 (7): 783–95. ISSN 0890-9369. PMID 7926767. doi:10.1101/gad.8.7.783 
  19. ↑ Okkenhaug, K; Rottapel R (agosto de 1998). «Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction». UNITED STATES. J. Biol. Chem. 273 (33): 21194–202. ISSN 0021-9258. PMID 9694876. doi:10.1074/jbc.273.33.21194 
  20. ↑ Nunès, J A; Truneh A, Olive D, Cantrell D A (janeiro de 1996). «Signal transduction by CD28 costimulatory receptor on T cells. B7-1 and B7-2 regulation of tyrosine kinase adaptor molecules». UNITED STATES. J. Biol. Chem. 271 (3): 1591–8. ISSN 0021-9258. PMID 8576157 
  21. ↑ Ong, S H; Goh K C, Lim Y P, Low B C, Klint P, Claesson-Welsh L, Cao X, Tan Y H, Guy G R (agosto de 1996). «Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2». UNITED STATES. Biochem. Biophys. Res. Commun. 225 (3): 1021–6. ISSN 0006-291X. PMID 8780727. doi:10.1006/bbrc.1996.1288 
  22. ↑ a b c Wong, Andy; Lamothe Betty, Lee Arnold, Schlessinger Joseph, Lax Irit, Li Arnold (maio de 2002). «FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl». United States. Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6684–9. ISSN 0027-8424. PMID 11997436. doi:10.1073/pnas.052138899 
  23. ↑ Meakin, S O; MacDonald J I, Gryz E A, Kubu C J, Verdi J M (abril de 1999). «The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation». UNITED STATES. J. Biol. Chem. 274 (14): 9861–70. ISSN 0021-9258. PMID 10092678. doi:10.1074/jbc.274.14.9861 
  24. ↑ Kouhara, H; Hadari Y R, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J (maio de 1997). «A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway». UNITED STATES. Cell. 89 (5): 693–702. ISSN 0092-8674. PMID 9182757. doi:10.1016/S0092-8674(00)80252-4 
  25. ↑ Saleem, A; Datta R, Yuan Z M, Kharbanda S, Kufe D (dezembro de 1995). «Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents». UNITED STATES. Cell Growth Differ. 6 (12): 1651–8. ISSN 1044-9523. PMID 9019171 
  26. ↑ Kharbanda, S; Saleem A, Shafman T, Emoto Y, Taneja N, Rubin E, Weichselbaum R, Woodgett J, Avruch J, Kyriakis J (agosto de 1995). «Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase». UNITED STATES. J. Biol. Chem. 270 (32): 18871–4. ISSN 0021-9258. PMID 7642542. doi:10.1074/jbc.270.32.18871 
  27. ↑ Poe, J C; Fujimoto M, Jansen P J, Miller A S, Tedder T F (junho de 2000). «CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux». UNITED STATES. J. Biol. Chem. 275 (23): 17420–7. ISSN 0021-9258. PMID 10748054. doi:10.1074/jbc.M001892200 
  28. ↑ Otipoby, K L; Draves K E, Clark E A (novembro de 2001). «CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1». United States. J. Biol. Chem. 276 (47): 44315–22. ISSN 0021-9258. PMID 11551923. doi:10.1074/jbc.M105446200 
  29. ↑ Sasaki, Akinori; Hata Keiko, Suzuki Susumu, Sawada Masashi, Wada Tadashi, Yamaguchi Kazunori, Obinata Masuo, Tateno Hiroo, Suzuki Hiroshi, Miyagi Taeko (julho de 2003). «Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice». United States. J. Biol. Chem. 278 (30): 27896–902. ISSN 0021-9258. PMID 12730204. doi:10.1074/jbc.M212200200 
  30. ↑ Lim, R W; Halpain S (julho de 2000). «Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein». UNITED STATES. J. Biol. Chem. 275 (27): 20578–87. ISSN 0021-9258. PMID 10781592. doi:10.1074/jbc.M001887200 
  31. ↑ Zamora-Leon, S P; Lee G, Davies P, Shafit-Zagardo B (outubro de 2001). «Binding of Fyn to MAP-2c through an SH3 binding domain. Regulation of the interaction by ERK2». United States. J. Biol. Chem. 276 (43): 39950–8. ISSN 0021-9258. PMID 11546790. doi:10.1074/jbc.M107807200 
  32. ↑ Hsia, Datsun A; Mitra Satyajit K, Hauck Christof R, Streblow Daniel N, Nelson Jay A, Ilic Dusko, Huang Shuang, Li Erguang, Nemerow Glen R, Leng Jay, Spencer Kathryn S R, Cheresh David A, Schlaepfer David D (março de 2003). «Differential regulation of cell motility and invasion by FAK». United States. J. Cell Biol. 160 (5): 753–67. ISSN 0021-9525. PMID 12615911. doi:10.1083/jcb.200212114 
  33. ↑ Hasegawa, H; Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M (abril de 1996). «DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane». UNITED STATES. Mol. Cell. Biol. 16 (4): 1770–6. ISSN 0270-7306. PMID 8657152 
  34. ↑ Saleem, A; Kharbanda S, Yuan Z M, Kufe D (maio de 1995). «Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes». UNITED STATES. J. Biol. Chem. 270 (18): 10380–3. ISSN 0021-9258. PMID 7737969. doi:10.1074/jbc.270.18.10380 
  35. ↑ Wang, J; Auger K R, Jarvis L, Shi Y, Roberts T M (maio de 1995). «Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase». UNITED STATES. J. Biol. Chem. 270 (21): 12774–80. ISSN 0021-9258. PMID 7759531. doi:10.1074/jbc.270.21.12774 
  36. ↑ Qian, X; Riccio A, Zhang Y, Ginty D D (novembro de 1998). «Identification and characterization of novel substrates of Trk receptors in developing neurons». UNITED STATES. Neuron. 21 (5): 1017–29. ISSN 0896-6273. PMID 9856458. doi:10.1016/S0896-6273(00)80620-0 
  37. ↑ Kotani, K; Wilden P, Pillay T S (outubro de 1998). «SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase». ENGLAND. Biochem. J. 335 ( Pt 1): 103–9. ISSN 0264-6021. PMID 9742218 
  38. ↑ Riordan, S M; Lidder S, Williams R, Skouteris G G (setembro de 2000). «The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis». ENGLAND. Biochem. J. 350 Pt 3: 925–32. ISSN 0264-6021. PMID 10970810 
  39. ↑ Matsuda, M; Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T (junho de 1996). «Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins». UNITED STATES. J. Biol. Chem. 271 (24): 14468–72. ISSN 0021-9258. PMID 8662907. doi:10.1074/jbc.271.24.14468 
  40. ↑ a b Okada, S; Pessin J E (outubro de 1996). «Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor». UNITED STATES. J. Biol. Chem. 271 (41): 25533–8. ISSN 0021-9258. PMID 8810325. doi:10.1074/jbc.271.41.25533 
  41. ↑ a b c d Oneyama, Chitose; Nakano Hirofumi, Sharma Sreenath V (março de 2002). «UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug». England. Oncogene. 21 (13): 2037–50. ISSN 0950-9232. PMID 11960376. doi:10.1038/sj.onc.1205271 
  42. ↑ Holgado-Madruga, M; Emlet D R, Moscatello D K, Godwin A K, Wong A J (fevereiro de 1996). «A Grb2-associated docking protein in EGF- and insulin-receptor signalling». ENGLAND. Nature. 379 (6565): 560–4. ISSN 0028-0836. PMID 8596638. doi:10.1038/379560a0 
  43. ↑ Li, B Q; Wang M H, Kung H F, Ronsin C, Breathnach R, Leonard E J, Kamata T (novembro de 1995). «Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor». UNITED STATES. Biochem. Biophys. Res. Commun. 216 (1): 110–8. ISSN 0006-291X. PMID 7488076. doi:10.1006/bbrc.1995.2598 
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  45. ↑ Miki, H; Miura K, Matuoka K, Nakata T, Hirokawa N, Orita S, Kaibuchi K, Takai Y, Takenawa T (fevereiro de 1994). «Association of Ash/Grb-2 with dynamin through the Src homology 3 domain». UNITED STATES. J. Biol. Chem. 269 (8): 5489–92. ISSN 0021-9258. PMID 8119878 
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  49. ↑ a b c d e f Saci, Abdelhafid; Liu Wang-Qing, Vidal Michel, Garbay Christiane, Rendu Francine, Bachelot-Loza Christilla (maio de 2002). «Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement». England. Biochem. J. 363 (Pt 3): 717–25. ISSN 0264-6021. PMID 11964172. doi:10.1042/0264-6021:3630717 
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  51. ↑ a b c d e Blagoev, Blagoy; Kratchmarova Irina, Ong Shao-En, Nielsen Mogens, Foster Leonard J, Mann Matthias (março de 2003). «A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling». United States. Nat. Biotechnol. 21 (3): 315–8. ISSN 1087-0156. PMID 12577067. doi:10.1038/nbt790 
  52. ↑ a b Bourguignon, L Y; Zhu H, Zhou B, Diedrich F, Singleton P A, Hung M C (dezembro de 2001). «Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth». United States. J. Biol. Chem. 276 (52): 48679–92. ISSN 0021-9258. PMID 11606575. doi:10.1074/jbc.M106759200 
  53. ↑ Poghosyan, Zaruhi; Robbins Stephen M, Houslay Miles D, Webster Ailsa, Murphy Gillian, Edwards Dylan R (fevereiro de 2002). «Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases». United States. J. Biol. Chem. 277 (7): 4999–5007. ISSN 0021-9258. PMID 11741929. doi:10.1074/jbc.M107430200 
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  55. ↑ Tanaka, S; Morishita T, Hashimoto Y, Hattori S, Nakamura S, Shibuya M, Matuoka K, Takenawa T, Kurata T, Nagashima K (abril de 1994). «C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins». UNITED STATES. Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3443–7. ISSN 0027-8424. PMID 7512734. doi:10.1073/pnas.91.8.3443 
  56. ↑ Song, J S; Gomez J, Stancato L F, Rivera J (outubro de 1996). «Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex». UNITED STATES. J. Biol. Chem. 271 (43): 26962–70. ISSN 0021-9258. PMID 8900182. doi:10.1074/jbc.271.43.26962 
  57. ↑ Ye, Z S; Baltimore D (dezembro de 1994). «Binding of Vav to Grb2 through dimerization of Src homology 3 domains». UNITED STATES. Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12629–33. ISSN 0027-8424. PMID 7809090. doi:10.1073/pnas.91.26.12629 
  58. ↑ a b Germani, A; Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N (maio de 1999). «hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways». UNITED STATES. Mol. Cell. Biol. 19 (5): 3798–807. ISSN 0270-7306. PMID 10207103 
  59. ↑ a b Lee, I S; Liu Y, Narazaki M, Hibi M, Kishimoto T, Taga T (janeiro de 1997). «Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6». NETHERLANDS. FEBS Lett. 401 (2-3): 133–7. ISSN 0014-5793. PMID 9013873. doi:10.1016/S0014-5793(96)01456-1 
  60. ↑ a b Schulze, Waltraud X; Deng Lei, Mann Matthias (2005). «Phosphotyrosine interactome of the ErbB-receptor kinase family». England. Mol. Syst. Biol. 1. 2005.0008 páginas. PMID 16729043. doi:10.1038/msb4100012 
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  137. ↑ Tang, H; Zhao Z J, Huang X Y, Landon E J, Inagami T (abril de 1999). «Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells». UNITED STATES. J. Biol. Chem. 274 (18): 12401–7. ISSN 0021-9258. PMID 10212213. doi:10.1074/jbc.274.18.12401 
  138. ↑ Hadari, Y R; Kouhara H, Lax I, Schlessinger J (julho de 1998). «Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation». UNITED STATES. Mol. Cell. Biol. 18 (7): 3966–73. ISSN 0270-7306. PMID 9632781 
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  140. ↑ Kon-Kozlowski, M; Pani G, Pawson T, Siminovitch K A (fevereiro de 1996). «The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells». UNITED STATES. J. Biol. Chem. 271 (7): 3856–62. ISSN 0021-9258. PMID 8632004. doi:10.1074/jbc.271.7.3856 
  141. ↑ Oehrl, W; Kardinal C, Ruf S, Adermann K, Groffen J, Feng G S, Blenis J, Tan T H, Feller S M (outubro de 1998). «The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins». ENGLAND. Oncogene. 17 (15): 1893–901. ISSN 0950-9232. PMID 9788432. doi:10.1038/sj.onc.1202108 
  142. ↑ Anafi, M; Kiefer F, Gish G D, Mbamalu G, Iscove N N, Pawson T (outubro de 1997). «SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1». UNITED STATES. J. Biol. Chem. 272 (44): 27804–11. ISSN 0021-9258. PMID 9346925. doi:10.1074/jbc.272.44.27804 
  143. ↑ Ling, P; Yao Z, Meyer C F, Wang X S, Oehrl W, Feller S M, Tan T H (fevereiro de 1999). «Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase». UNITED STATES. Mol. Cell. Biol. 19 (2): 1359–68. ISSN 0270-7306. PMID 9891069 
  144. ↑ Ling, P; Meyer C F, Redmond L P, Shui J W, Davis B, Rich R R, Hu M C, Wange R L, Tan T H (junho de 2001). «Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling». United States. J. Biol. Chem. 276 (22): 18908–14. ISSN 0021-9258. PMID 11279207. doi:10.1074/jbc.M101485200 
  145. ↑ Banin, S; Truong O, Katz D R, Waterfield M D, Brickell P M, Gout I (agosto de 1996). «Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases». ENGLAND. Curr. Biol. 6 (8): 981–8. ISSN 0960-9822. PMID 8805332. doi:10.1016/S0960-9822(02)00642-5 
  146. ↑ She, H Y; Rockow S, Tang J, Nishimura R, Skolnik E Y, Chen M, Margolis B, Li W (setembro de 1997). «Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells». UNITED STATES. Mol. Biol. Cell. 8 (9): 1709–21. ISSN 1059-1524. PMID 9307968 
  147. ↑ Satoh, S; Tominaga T (outubro de 2001). «mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation». United States. J. Biol. Chem. 276 (42): 39290–4. ISSN 0021-9258. PMID 11509578. doi:10.1074/jbc.M107026200 
  148. ↑ Fukuoka, M; Suetsugu S, Miki H, Fukami K, Endo T, Takenawa T (fevereiro de 2001). «A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42». United States. J. Cell Biol. 152 (3): 471–82. ISSN 0021-9525. PMID 11157975. doi:10.1083/jcb.152.3.471 
  149. ↑ den Hertog, J; Hunter T (junho de 1996). «Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains». ENGLAND. EMBO J. 15 (12): 3016–27. ISSN 0261-4189. PMID 8670803 
  150. ↑ den Hertog, J; Tracy S, Hunter T (julho de 1994). «Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo». ENGLAND. EMBO J. 13 (13): 3020–32. ISSN 0261-4189. PMID 7518772 
  151. ↑ Zheng, Xin-Min; Resnick Ross J, Shalloway David (junho de 2002). «Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation». United States. J. Biol. Chem. 277 (24): 21922–9. ISSN 0021-9258. PMID 11923305. doi:10.1074/jbc.M201394200 
  152. ↑ Million, R P; Van Etten R A (julho de 2000). «The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase». UNITED STATES. Blood. 96 (2): 664–70. ISSN 0006-4971. PMID 10887132 
  153. ↑ Bai, R Y; Jahn T, Schrem S, Munzert G, Weidner K M, Wang J Y, Duyster J (agosto de 1998). «The SH2-containing adapter protein GRB10 interacts with BCR-ABL». ENGLAND. Oncogene. 17 (8): 941–8. ISSN 0950-9232. PMID 9747873. doi:10.1038/sj.onc.1202024 
  154. ↑ Ma, G; Lu D, Wu Y, Liu J, Arlinghaus R B (maio de 1997). «Bcr phosphorylated on tyrosine 177 binds Grb2». ENGLAND. Oncogene. 14 (19): 2367–72. ISSN 0950-9232. PMID 9178913. doi:10.1038/sj.onc.1201053 
  155. ↑ Maru, Y; Peters K L, Afar D E, Shibuya M, Witte O N, Smithgall T E (fevereiro de 1995). «Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS». UNITED STATES. Mol. Cell. Biol. 15 (2): 835–42. ISSN 0270-7306. PMID 7529874 
  156. ↑ a b Ettenberg, S A; Keane M M, Nau M M, Frankel M, Wang L M, Pierce J H, Lipkowitz S (março de 1999). «cbl-b inhibits epidermal growth factor receptor signaling». ENGLAND. Oncogene. 18 (10): 1855–66. ISSN 0950-9232. PMID 10086340. doi:10.1038/sj.onc.1202499 
  157. ↑ Lavagna-Sévenier, C; Marchetto S, Birnbaum D, Rosnet O (junho de 1998). «The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells». UNITED STATES. J. Biol. Chem. 273 (24): 14962–7. ISSN 0021-9258. PMID 9614102. doi:10.1074/jbc.273.24.14962 
  158. ↑ Elly, C; Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu Y C (fevereiro de 1999). «Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation». ENGLAND. Oncogene. 18 (5): 1147–56. ISSN 0950-9232. PMID 10022120. doi:10.1038/sj.onc.1202411 
  159. ↑ Jain, S K; Langdon W Y, Varticovski L (maio de 1997). «Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase». ENGLAND. Oncogene. 14 (18): 2217–28. ISSN 0950-9232. PMID 9174058. doi:10.1038/sj.onc.1201049 
  160. ↑ Robertson, H; Langdon W Y, Thien C B, Bowtell D D (novembro de 1997). «A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components». UNITED STATES. Biochem. Biophys. Res. Commun. 240 (1): 46–50. ISSN 0006-291X. PMID 9367879. doi:10.1006/bbrc.1997.7608 
  161. ↑ Donovan, J A; Wange R L, Langdon W Y, Samelson L E (setembro de 1994). «The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor». UNITED STATES. J. Biol. Chem. 269 (37): 22921–4. ISSN 0021-9258. PMID 8083187 
  162. ↑ Gesbert, F; Garbay C, Bertoglio J (fevereiro de 1998). «Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells». UNITED STATES. J. Biol. Chem. 273 (7): 3986–93. ISSN 0021-9258. PMID 9461587. doi:10.1074/jbc.273.7.3986 
  163. ↑ Husson, H; Mograbi B, Schmid-Antomarchi H, Fischer S, Rossi B (maio de 1997). «CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2». ENGLAND. Oncogene. 14 (19): 2331–8. ISSN 0950-9232. PMID 9178909. doi:10.1038/sj.onc.1201074 
  164. ↑ Odai, H; Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T, Mitani K, Yazaki Y, Hirai H (abril de 1997). «Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl». UNITED STATES. Blood. 89 (8): 2745–56. ISSN 0006-4971. PMID 9108392 
  165. ↑ Ng, Cherlyn; Jackson Rebecca A, Buschdorf Jan P, Sun Qingxiang, Guy Graeme R, Sivaraman J (março de 2008). «Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates». England. EMBO J. 27 (5): 804–16. PMID 18273061. doi:10.1038/emboj.2008.18 
  166. ↑ Li, N; Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J (maio de 1993). «Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling». ENGLAND. Nature. 363 (6424): 85–8. ISSN 0028-0836. PMID 8479530. doi:10.1038/363085a0 
  167. ↑ Reif, K; Buday L, Downward J, Cantrell D A (maio de 1994). «SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases». UNITED STATES. J. Biol. Chem. 269 (19): 14081–7. ISSN 0021-9258. PMID 8188688 
  168. ↑ D'Angelo, G; Martini J F, Iiri T, Fantl W J, Martial J, Weiner R I (maio de 1999). «16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells». UNITED STATES. Mol. Endocrinol. 13 (5): 692–704. ISSN 0888-8809. PMID 10319320. doi:10.1210/me.13.5.692 
  169. ↑ Tong, X K; Hussain N K, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn C C, Olson M F, Marais R, Baranes D, Kay B K, McPherson P S (março de 2000). «The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain». ENGLAND. EMBO J. 19 (6): 1263–71. ISSN 0261-4189. PMID 10716926. doi:10.1093/emboj/19.6.1263 
  170. ↑ Chin, H; Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O (outubro de 1997). «Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells». UNITED STATES. Biochem. Biophys. Res. Commun. 239 (2): 412–7. ISSN 0006-291X. PMID 9344843. doi:10.1006/bbrc.1997.7480 
  171. ↑ Morrison, Kevin B; Tognon Cristina E, Garnett Mathew J, Deal Cheri, Sorensen Poul H B (agosto de 2002). «ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation». England. Oncogene. 21 (37): 5684–95. ISSN 0950-9232. PMID 12173038. doi:10.1038/sj.onc.1205669 
  172. ↑ Kato-Stankiewicz, J; Ueda S, Kataoka T, Kaziro Y, Satoh T (junho de 2001). «Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner». United States. Biochem. Biophys. Res. Commun. 284 (2): 470–7. ISSN 0006-291X. PMID 11394904. doi:10.1006/bbrc.2001.5004 
  173. ↑ Wiederhold, Thorsten; Lee Ming-Fen, James Marianne, Neujahr Ralph, Smith Nicole, Murthy Anita, Hartwig John, Gusella James F, Ramesh Vijaya (novembro de 2004). «Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2». England. Oncogene. 23 (54): 8815–25. ISSN 0950-9232. PMID 15467741. doi:10.1038/sj.onc.1208110 
  174. ↑ Pomérance, M; Multon M C, Parker F, Venot C, Blondeau J P, Tocqué B, Schweighoffer F (setembro de 1998). «Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor». UNITED STATES. J. Biol. Chem. 273 (38): 24301–4. ISSN 0021-9258. PMID 9733714. doi:10.1074/jbc.273.38.24301 
  175. ↑ Romero, F; Ramos-Morales F, Domínguez A, Rios R M, Schweighoffer F, Tocqué B, Pintor-Toro J A, Fischer S, Tortolero M (março de 1998). «Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA». UNITED STATES. J. Biol. Chem. 273 (13): 7776–81. ISSN 0021-9258. PMID 9516488. doi:10.1074/jbc.273.13.7776 

Leitura de apoio[editar | editar código-fonte]

  • Colledge M, Froehner SC (1998). «Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction.». Ann. N. Y. Acad. Sci. 841: 17–27. PMID 9668219. doi:10.1111/j.1749-6632.1998.tb10907.x 
  • Ramesh N, Antón IM, Martínez-Quiles N, Geha RS (1999). «Waltzing with WASP.». Trends Cell Biol. 9 (1): 15–9. PMID 10087612. doi:10.1016/S0962-8924(98)01411-1 
  • O'Sullivan E, Kinnon C, Brickell P (1999). «Wiskott-Aldrich syndrome protein, WASP.». Int. J. Biochem. Cell Biol. 31 (3-4): 383–7. PMID 10224664. doi:10.1016/S1357-2725(98)00118-6 
  • Schlaepfer DD, Hauck CR, Sieg DJ (1999). «Signaling through focal adhesion kinase.». Prog. Biophys. Mol. Biol. 71 (3-4): 435–78. PMID 10354709. doi:10.1016/S0079-6107(98)00052-2 
  • Vidal M, Liu WQ, Gril B; et al. (2004). «[Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2]». J. Soc. Biol. 198 (2): 133–7. PMID 15368963 

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