Lomefloxacino
Aspeto
Nome IUPAC (sistemática) | |
(RS)-1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid | |
Identificadores | |
CAS | 98079-51-7 |
ATC | J01MA07 |
PubChem | 3948 |
DrugBank | DB00978 |
ChemSpider | |
Informação química | |
Fórmula molecular | C17H19N3F2O3 |
Massa molar | 351.354 g/mol |
SMILES | Fc1c(c(F)c2c(c1)C(=O)C(\C(=O)O)=C/N2CC)N3CC(NCC3)C |
Farmacocinética | |
Biodisponibilidade | ? |
Metabolismo | ? |
Meia-vida | 6-7 horas |
Excreção | ? |
Considerações terapêuticas | |
Administração | oral |
DL50 | ? |
Lomefloxacino é um fármaco antibiótico do grupo das fluoroquinolonas.[1]
Uso clínico
[editar | editar código-fonte]O lomefloxacino é utilizado no tratamento das infeções renais e das vias urinárias,[2][3][4] das infeções da próstata[5][6][7] e das vias respiratórias[8][9][10][11][12].
Referências
- ↑ P.R.Vademécum
- ↑ Pisani, E.; R. Bartoletti; A. Trinchieri; M. Rizzo (1996). «Lomefloxacin versus ciprofloxacin in the treatment of complicated urinary tract infections: a multicenter study.». J Chemother. 8 (3): 210-3. PMID 8808718
- ↑ Klimberg, IW.; CE. Cox; CL. Fowler; W. King; SS. Kim; S. Callery-D'Amico (1998). «A controlled trial of levofloxacin and lomefloxacin in the treatment of complicated urinary tract infection.». Urology. 51 (4): 610-5. PMID 9586615
- ↑ Guibert, J.; H. Herman; MH. Capron (1997). «[Treatment of uncomplicated recurrent cystitis in women: lomefloxacin versus norfloxacin].». Contracept Fertil Sex. 25 (1): 79-84. PMID 9064058
- ↑ Andriole, VT. (1991). «Use of quinolones in treatment of prostatitis and lower urinary tract infections.». Eur J Clin Microbiol Infect Dis. 10 (4): 342-50. PMID 1864295
- ↑ Naber, KG. (2002). «Lomefloxacin versus ciprofloxacin in the treatment of chronic bacterial prostatitis.». Int J Antimicrob Agents. 20 (1): 18-27. PMID 12127707
- ↑ Costa, FJ. (1994). «Lomefloxacin prophylaxis in visual laser ablation of the prostate.». Urology. 44 (6): 933-6. PMID 7527170
- ↑ Melani, AS.; M. Pirrelli; F. Sarlo; V. Cantoni (2001). «Safety and effectiveness of lomefloxacin in patients with acute exacerbation of chronic bronchitis (AECB) chronically treated with oral theophyllines.». J Chemother. 13 (6): 628-34. PMID 11806624
- ↑ Fedoseev, GB.; AV. Emel'ianov; KA. Rudinskiĭ; SE. Shevelev; AV. Bykova. «[Efficacy of lomefloxacin in treatment of patients with chronic bronchitis].». Antibiot Khimioter. 43 (10): 24-6. PMID 9825106
- ↑ Grassi, C.; C. Albera; E. Pozzi (1992). «Lomefloxacin versus amoxicillin in the treatment of acute exacerbations of chronic bronchitis: an Italian multicenter study.». Am J Med. 92 (4A): 103S-107S. PMID 1316058
- ↑ Belousov, IuB.; OV. Efremenkova; AV. Sokolov; IF. Tishenkova (1999). «[The importance of fluoroquinolones in treating pneumonia in the elderly].». Antibiot Khimioter. 44 (12): 23-6. PMID 10687030
- ↑ Kohno, S.; K. Yamaguchi; Y. Dohtsu; H. Koga; T. Hayashi; M. Hirota; A. Saito; K. Hara (1988). «Efficacy of NY-198 against experimental Legionnaires disease.». Antimicrob Agents Chemother. 32 (9): 1427-9. PMID 3196003