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No campo da biologia molecular, P2RY6 é uma proteína que pertence ao grupo dos receptores P2Y e que, em seres humanos, é codificada pelo gene P2RY6.[1][2]


  1. Communi D, Parmentier M, Boeynaems JM (1996). «Cloning, functional expression and tissue distribution of the human P2Y6 receptor». Biochem Biophys Res Commun. 222 (2): 303–8. PMID 8670200. doi:10.1006/bbrc.1996.0739 
  2. «Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6» 

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  • Loomis WH, Namiki S, Ostrom RS; et al. (2003). «Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation.». J. Biol. Chem. 278 (7): 4590–6. PMID 12464620. doi:10.1074/jbc.M207868200 
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  • Kim SG, Soltysiak KA, Gao ZG; et al. (2003). «Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.». Biochem. Pharmacol. 65 (6): 923–31. PMID 12623123. doi:10.1016/S0006-2952(02)01614-3 
  • Schafer R, Sedehizade F, Welte T, Reiser G (2003). «ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells.». Am. J. Physiol. Lung Cell Mol. Physiol. 285 (2): L376–85. PMID 12691958. doi:10.1152/ajplung.00447.2002 
  • Lee H, Choi BH, Suh BC; et al. (2003). «Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells.». J. Neurochem. 85 (4): 1043–53. PMID 12716436 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928Acessível livremente. PMID 15489334. doi:10.1101/gr.2596504 
  • Wan D, Gong Y, Qin W; et al. (2004). «Large-scale cDNA transfection screening for genes related to cancer development and progression.». Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. PMC 524842Acessível livremente. PMID 15498874. doi:10.1073/pnas.0404089101 
  • Cox MA, Gomes B, Palmer K; et al. (2005). «The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP.». Biochem. Biophys. Res. Commun. 330 (2): 467–73. PMID 15796906. doi:10.1016/j.bbrc.2005.03.004 
  • Khine AA, Del Sorbo L, Vaschetto R; et al. (2006). «Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway.». Blood. 107 (7): 2936–42. PMID 16322472. doi:10.1182/blood-2005-06-2314 
  • Wihlborg AK, Balogh J, Wang L; et al. (2006). «Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction.». Circ. Res. 98 (7): 970–6. PMID 16543499. doi:10.1161/01.RES.0000217402.73402.cd 
  • Dulong S, Bernard K, Ehrenfeld J (2007). «Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells.». Cell. Physiol. Biochem. 20 (5): 483–94. PMID 17762175. doi:10.1159/000107532 
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