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No campo da biologia molecular, P2RY6 é uma proteína que pertence ao grupo dos receptores P2Y e que, em seres humanos, é codificada pelo gene P2RY6.[1][2]


  1. Communi D, Parmentier M, Boeynaems JM (1996). «Cloning, functional expression and tissue distribution of the human P2Y6 receptor»: 303–8. doi:10.1006/bbrc.1996.0739. PMID 8670200 
  2. «Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6» 

Leitura de apoio[editar | editar código-fonte]

  • Maier R, Glatz A, Mosbacher J, Bilbe G (1997). «Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.»: 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704 
  • Somers GR, Hammet F, Woollatt E; et al. (1997). «Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family.»: 127–30. doi:10.1006/geno.1997.4841. PMID 9286708 
  • Maier R, Glatz A, Mosbacher J, Bilbe G (1997). «Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.»: 298–302. PMID 9412455 
  • Pidlaoan LV, Jin J, Sandhu AK; et al. (1998). «Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome 11q13.3-14.1.»: 291–6. doi:10.1007/BF02674420. PMID 9542531 
  • Brinson AE, Harden TK (2001). «Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.»: 11939–48. doi:10.1074/jbc.M009909200. PMID 11114308 
  • Moore DJ, Chambers JK, Wahlin JP; et al. (2001). «Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.»: 107–19. PMID 11690642 
  • Hou M, Harden TK, Kuhn CM; et al. (2002). «UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.»: H784–92. doi:10.1152/ajpheart.00997.2000. PMID 11788430 
  • Loomis WH, Namiki S, Ostrom RS; et al. (2003). «Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation.»: 4590–6. doi:10.1074/jbc.M207868200. PMID 12464620 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.»: 16899–903. doi:10.1073/pnas.242603899. PMC 139241Acessível livremente. PMID 12477932 
  • Kim SG, Soltysiak KA, Gao ZG; et al. (2003). «Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.»: 923–31. doi:10.1016/S0006-2952(02)01614-3. PMID 12623123 
  • Schafer R, Sedehizade F, Welte T, Reiser G (2003). «ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells.»: L376–85. doi:10.1152/ajplung.00447.2002. PMID 12691958 
  • Lee H, Choi BH, Suh BC; et al. (2003). «Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells.»: 1043–53. PMID 12716436 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).»: 2121–7. doi:10.1101/gr.2596504. PMC 528928Acessível livremente. PMID 15489334 
  • Wan D, Gong Y, Qin W; et al. (2004). «Large-scale cDNA transfection screening for genes related to cancer development and progression.»: 15724–9. doi:10.1073/pnas.0404089101. PMC 524842Acessível livremente. PMID 15498874 
  • Cox MA, Gomes B, Palmer K; et al. (2005). «The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP.»: 467–73. doi:10.1016/j.bbrc.2005.03.004. PMID 15796906 
  • Khine AA, Del Sorbo L, Vaschetto R; et al. (2006). «Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway.»: 2936–42. doi:10.1182/blood-2005-06-2314. PMID 16322472 
  • Wihlborg AK, Balogh J, Wang L; et al. (2006). «Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction.»: 970–6. doi:10.1161/01.RES.0000217402.73402.cd. PMID 16543499 
  • Dulong S, Bernard K, Ehrenfeld J (2007). «Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells.»: 483–94. doi:10.1159/000107532. PMID 17762175 
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