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No campo da biologia molecular, P2RY6 é uma proteína que pertence ao grupo dos receptores P2Y e que, em seres humanos, é codificada pelo gene P2RY6.[1][2]


  1. Communi D, Parmentier M, Boeynaems JM (1996). «Cloning, functional expression and tissue distribution of the human P2Y6 receptor». Biochem Biophys Res Commun [S.l.: s.n.] 222 (2): 303–8. doi:10.1006/bbrc.1996.0739. PMID 8670200. 
  2. «Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6». 

Leitura de apoio[editar | editar código-fonte]

  • Maier R, Glatz A, Mosbacher J, Bilbe G (1997). «Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.». Biochem. Biophys. Res. Commun. [S.l.: s.n.] 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704. 
  • Somers GR, Hammet F, Woollatt E; et al. (1997). «Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family.». Genomics [S.l.: s.n.] 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708. 
  • Maier R, Glatz A, Mosbacher J, Bilbe G (1997). «Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.». Biochem. Biophys. Res. Commun. [S.l.: s.n.] 240 (2): 298–302. PMID 9412455. 
  • Pidlaoan LV, Jin J, Sandhu AK; et al. (1998). «Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome 11q13.3-14.1.». Somat. Cell Mol. Genet. [S.l.: s.n.] 23 (4): 291–6. doi:10.1007/BF02674420. PMID 9542531. 
  • Brinson AE, Harden TK (2001). «Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.». J. Biol. Chem. [S.l.: s.n.] 276 (15): 11939–48. doi:10.1074/jbc.M009909200. PMID 11114308. 
  • Moore DJ, Chambers JK, Wahlin JP; et al. (2001). «Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.». Biochim. Biophys. Acta [S.l.: s.n.] 1521 (1-3): 107–19. PMID 11690642. 
  • Hou M, Harden TK, Kuhn CM; et al. (2002). «UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.». Am. J. Physiol. Heart Circ. Physiol. [S.l.: s.n.] 282 (2): H784–92. doi:10.1152/ajpheart.00997.2000. PMID 11788430. 
  • Loomis WH, Namiki S, Ostrom RS; et al. (2003). «Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation.». J. Biol. Chem. [S.l.: s.n.] 278 (7): 4590–6. doi:10.1074/jbc.M207868200. PMID 12464620. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. [S.l.: s.n.] 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Kim SG, Soltysiak KA, Gao ZG; et al. (2003). «Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.». Biochem. Pharmacol. [S.l.: s.n.] 65 (6): 923–31. doi:10.1016/S0006-2952(02)01614-3. PMID 12623123. 
  • Schafer R, Sedehizade F, Welte T, Reiser G (2003). «ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells.». Am. J. Physiol. Lung Cell Mol. Physiol. [S.l.: s.n.] 285 (2): L376–85. doi:10.1152/ajplung.00447.2002. PMID 12691958. 
  • Lee H, Choi BH, Suh BC; et al. (2003). «Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells.». J. Neurochem. [S.l.: s.n.] 85 (4): 1043–53. PMID 12716436. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. [S.l.: s.n.] 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Wan D, Gong Y, Qin W; et al. (2004). «Large-scale cDNA transfection screening for genes related to cancer development and progression.». Proc. Natl. Acad. Sci. U.S.A. [S.l.: s.n.] 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. 
  • Cox MA, Gomes B, Palmer K; et al. (2005). «The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP.». Biochem. Biophys. Res. Commun. [S.l.: s.n.] 330 (2): 467–73. doi:10.1016/j.bbrc.2005.03.004. PMID 15796906. 
  • Khine AA, Del Sorbo L, Vaschetto R; et al. (2006). «Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway.». Blood [S.l.: s.n.] 107 (7): 2936–42. doi:10.1182/blood-2005-06-2314. PMID 16322472. 
  • Wihlborg AK, Balogh J, Wang L; et al. (2006). «Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction.». Circ. Res. [S.l.: s.n.] 98 (7): 970–6. doi:10.1161/01.RES.0000217402.73402.cd. PMID 16543499. 
  • Dulong S, Bernard K, Ehrenfeld J (2007). «Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells.». Cell. Physiol. Biochem. [S.l.: s.n.] 20 (5): 483–94. doi:10.1159/000107532. PMID 17762175. 
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