TRIM21
52 kDa Ro protein é uma proteína que em humanos é codificada pelo gene TRIM21.
Auxilia anticorpos no interior das células a combater infecções, movendo os atacantes (ex. vírus) para o sistema de eliminação celular. Esse mecanismo foi catalogado na revista científica Proceedings of the National Academy of Sciences em 2010 e pode ser a chave para a criação de medicamentos antivirais mais efetivos, pois até então, era apenas conhecido que os anticorpos agiam por bloqueio somente fora das células.[1]
Notas e referências
- ↑ G1. «Descoberta sobre anticorpos pode levar à cura do resfriado». Consultado em 3 de novembro de 2010
Leitura de apoio[editar | editar código-fonte]
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. PMID 1985094. doi:10.1172/JCI114968 - Chan EK, Hamel JC, Buyon JP, Tan EM (1991). «Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.». J. Clin. Invest. 87 (1): 68–76. PMC 294993. PMID 1985112. doi:10.1172/JCI115003
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- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.». Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
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- Tseng CE, Miranda E, Di Donato F; et al. (1999). «mRNA and protein expression of SSA/Ro and SSB/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure.». Pediatr. Res. 45 (2): 260–9. PMID 10022600. doi:10.1203/00006450-199902000-00018
- Fabini G, Rutjes SA, Zimmermann C; et al. (2000). «Analysis of the molecular composition of Ro ribonucleoprotein complexes. Identification of novel Y RNA-binding proteins.». Eur. J. Biochem. 267 (9): 2778–89. PMID 10785401. doi:10.1046/j.1432-1327.2000.01298.x
- Kurien BT, Chambers TL, Thomas PY; et al. (2001). «Autoantibody to the leucine zipper region of 52 kDa Ro/SSA binds native 60 kDa Ro/SSA: identification of a tertiary epitope with components from 60 kDa Ro/SSA and 52 kDa Ro/SSA.». Scand. J. Immunol. 53 (3): 268–76. PMID 11251884. doi:10.1046/j.1365-3083.2001.00870.x
- Reymond A, Meroni G, Fantozzi A; et al. (2001). «The tripartite motif family identifies cell compartments.». EMBO J. 20 (9): 2140–51. PMC 125245. PMID 11331580. doi:10.1093/emboj/20.9.2140
- Di Donato F, Chan EK, Askanase AD; et al. (2001). «Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function.». Int. J. Biochem. Cell Biol. 33 (9): 924–34. PMID 11461834. doi:10.1016/S1357-2725(01)00055-3
- Fukuda-Kamitani T, Kamitani T (2002). «Ubiquitination of Ro52 autoantigen.». Biochem. Biophys. Res. Commun. 295 (4): 774–8. PMID 12127959. doi:10.1016/S0006-291X(02)00750-7
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
