GSK3B

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Estrutura do GSK3B

GSK3B (glycogen synthase kinase 3 beta) é uma enzima que em humanos é codificada pelo gene GSK3B.

Interações[editar | editar código-fonte]

Interage com CTNNB1,[1][2] SGK3,[3] TSC2,[4][5] AR,[6] MUC1,[7][8] AXIN1,[9][4] PRKAR2A,[10] AKAP11,[10] DNM1L,[11] P53,[12] AXIN2,[13][14] NOTCH2,[15] SMAD3[16] and NOTCH1.[17]

Referências

  1. Davies, G; Jiang W G, Mason M D (2001). «The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer». Int. J. Oncol. (Greece [s.n.]) 18 (4): 843–7. ISSN 1019-6439. PMID 11251183. 
  2. Kishida, S; Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A (1999). «DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability». Mol. Cell. Biol. (UNITED STATES [s.n.]) 19 (6): 4414–22. ISSN 0270-7306. PMC 104400. PMID 10330181. 
  3. Dai, Fangyan; Yu Long, He Hua, Chen Yongjing, Yu Jianqiang, Yang Yumei, Xu YueFang, Ling Wenhai, Zhao Shouyuan (2002). «Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction». Biochem. Biophys. Res. Commun. (United States [s.n.]) 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. ISSN 0006-291X. PMID 12054501. 
  4. a b Mak, Baldwin C; Takemaru Ken-Ichi, Kenerson Heidi L, Moon Randall T, Yeung Raymond S (2003). «The tuberin-hamartin complex negatively regulates beta-catenin signaling activity». J. Biol. Chem. (United States [s.n.]) 278 (8): 5947–51. doi:10.1074/jbc.C200473200. ISSN 0021-9258. PMID 12511557. 
  5. Inoki, Ken; Ouyang Hongjiao, Zhu Tianqing, Lindvall Charlotta, Wang Yian, Zhang Xiaojie, Yang Qian, Bennett Christina, Harada Yuko, Stankunas Kryn, Wang Cun-Yu, He Xi, MacDougald Ormond A, You Ming, Williams Bart O, Guan Kun-Liang (2006). «TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth». Cell (United States [s.n.]) 126 (5): 955–68. doi:10.1016/j.cell.2006.06.055. ISSN 0092-8674. PMID 16959574.  Parâmetro desconhecido |unused_data= ignorado (Ajuda)
  6. Wang, Liang; Lin Hui-Kuan, Hu Yueh-Chiang, Xie Shaozhen, Yang Lin, Chang Chawnshang (2004). «Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells». J. Biol. Chem. (United States [s.n.]) 279 (31): 32444–52. doi:10.1074/jbc.M313963200. ISSN 0021-9258. PMID 15178691. 
  7. Li, Y; Bharti A, Chen D, Gong J, Kufe D (1998). «Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin». Mol. Cell. Biol. (UNITED STATES [s.n.]) 18 (12): 7216–24. ISSN 0270-7306. PMC 109303. PMID 9819408. 
  8. Li, Y; Kuwahara H, Ren J, Wen G, Kufe D (2001). «The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin». J. Biol. Chem. (United States [s.n.]) 276 (9): 6061–4. doi:10.1074/jbc.C000754200. ISSN 0021-9258. PMID 11152665. 
  9. Nakamura, T; Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T (1998). «Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level». Genes Cells (ENGLAND [s.n.]) 3 (6): 395–403. doi:10.1046/j.1365-2443.1998.00198.x. ISSN 1356-9597. PMID 9734785. 
  10. a b Tanji, Chie; Yamamoto Hideki, Yorioka Noriaki, Kohno Nobuoki, Kikuchi Kunimi, Kikuchi Akira (2002). «A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta». J. Biol. Chem. (United States [s.n.]) 277 (40): 36955–61. doi:10.1074/jbc.M206210200. ISSN 0021-9258. PMID 12147701. 
  11. Hong, Y R; Chen C H, Cheng D S, Howng S L, Chow C C (1998). «Human dynamin-like protein interacts with the glycogen synthase kinase 3beta». Biochem. Biophys. Res. Commun. (UNITED STATES [s.n.]) 249 (3): 697–703. doi:10.1006/bbrc.1998.9253. ISSN 0006-291X. PMID 9731200. 
  12. Watcharasit, Piyajit; Bijur Gautam N, Zmijewski Jaroslaw W, Song Ling, Zmijewska Anna, Chen Xinbin, Johnson Gail V W, Jope Richard S (2002). «Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage». Proc. Natl. Acad. Sci. U.S.A. (United States [s.n.]) 99 (12): 7951–5. doi:10.1073/pnas.122062299. ISSN 0027-8424. PMC 123001. PMID 12048243. 
  13. von Kries, J P; Winbeck G, Asbrand C, Schwarz-Romond T, Sochnikova N, Dell'Oro A, Behrens J, Birchmeier W (2000). «Hot spots in beta-catenin for interactions with LEF-1, conductin and APC». Nat. Struct. Biol. (UNITED STATES [s.n.]) 7 (9): 800–7. doi:10.1038/79039. ISSN 1072-8368. PMID 10966653. 
  14. Schwarz-Romond, Thomas; Asbrand Christian, Bakkers Jeroen, Kühl Michael, Schaeffer Hans-Joerg, Huelsken Jörg, Behrens Jürgen, Hammerschmidt Matthias, Birchmeier Walter (2002). «The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling». Genes Dev. (United States [s.n.]) 16 (16): 2073–84. doi:10.1101/gad.230402. ISSN 0890-9369. PMC 186448. PMID 12183362. 
  15. Espinosa, Lluís; Inglés-Esteve Julia, Aguilera Cristina, Bigas Anna (2003). «Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways». J. Biol. Chem. (United States [s.n.]) 278 (34): 32227–35. doi:10.1074/jbc.M304001200. ISSN 0021-9258. PMID 12794074. 
  16. Guo, Xing; Ramirez Alejandro, Waddell David S, Li Zhizhong, Liu Xuedong, Wang Xiao-Fan (2008). «Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling». Genes Dev. (United States [s.n.]) 22 (1): 106–20. doi:10.1101/gad.1590908. ISSN 0890-9369. PMC 2151009. PMID 18172167. 
  17. Foltz, Daniel R; Santiago Michelle C, Berechid Bridget E, Nye Jeffrey S (2002). «Glycogen synthase kinase-3beta modulates notch signaling and stability». Curr. Biol. (England [s.n.]) 12 (12): 1006–11. doi:10.1016/S0960-9822(02)00888-6. ISSN 0960-9822. PMID 12123574. 

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