STK11

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LKB1 (em rosa) no complexo LKB1-STRADα-MO25α

STK11 (Serine/threonine kinase 11) ou LKB1 é uma proteína tipo quinase codificada nos humanos pelo gene STK11.[1]

Referências

  1. Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller O, Back W, Zimmer M. (January 1998). "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase". Nature genetics 18 (1): 38–43. DOI:10.1038/ng0198-38. PMID 9425897.

Leitura de apoio[editar | editar código-fonte]

  • Yoo LI, Chung DC, Yuan J. (2002). "LKB1--a master tumour suppressor of the small intestine and beyond.". Nat. Rev. Cancer 2 (7): 529–35. DOI:10.1038/nrc843. PMID 12094239.
  • Baas AF, Smit L, Clevers H. (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity.". Trends Cell Biol. 14 (6): 312–9. DOI:10.1016/j.tcb.2004.04.001. PMID 15183188.
  • Katajisto P, Vallenius T, Vaahtomeri K, et al.. (2007). "The LKB1 tumor suppressor kinase in human disease.". Biochim. Biophys. Acta 1775 (1): 63–75. DOI:10.1016/j.bbcan.2006.08.003. PMID 17010524.
  • Bonaldo MF, Lennon G, Soares MB. (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
  • Hemminki A, Tomlinson I, Markie D, et al.. (1997). "Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis.". Nat. Genet. 15 (1): 87–90. DOI:10.1038/ng0197-87. PMID 8988175.
  • Jenne DE, Reimann H, Nezu J, et al.. (1998). "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.". Nat. Genet. 18 (1): 38–43. DOI:10.1038/ng0198-38. PMID 9425897.
  • Hemminki A, Markie D, Tomlinson I, et al.. (1998). "A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.". Nature 391 (6663): 184–7. DOI:10.1038/34432. PMID 9428765.
  • Bignell GR, Barfoot R, Seal S, et al.. (1998). "Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer.". Cancer Res. 58 (7): 1384–6. PMID 9537235.
  • Nakagawa H, Koyama K, Miyoshi Y, et al.. (1998). "Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.". Hum. Genet. 103 (2): 168–72. DOI:10.1007/s004390050801. PMID 9760200.
  • Mehenni H, Gehrig C, Nezu J, et al.. (1999). "Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.". Am. J. Hum. Genet. 63 (6): 1641–50. DOI:10.1086/302159. PMID 9837816.
  • Guldberg P, thor Straten P, Ahrenkiel V, et al.. (1999). "Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.". Oncogene 18 (9): 1777–80. DOI:10.1038/sj.onc.1202486. PMID 10208439.
  • Su GH, Hruban RH, Bansal RK, et al.. (1999). "Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers.". Am. J. Pathol. 154 (6): 1835–40. PMID 10362809.
  • Westerman AM, Entius MM, Boor PP, et al.. (1999). "Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.". Hum. Mutat. 13 (6): 476–81. DOI:<476::AID-HUMU7>3.0.CO;2-2 10.1002/(SICI)1098-1004(1999)13:6<476::AID-HUMU7>3.0.CO;2-2. PMID 10408777.
  • Scanlan MJ, Gordan JD, Williamson B, et al.. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. DOI:<456::AID-IJC4>3.0.CO;2-5 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
  • Collins SP, Reoma JL, Gamm DM, Uhler MD. (2000). "LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.". Biochem. J. 345 Pt 3: 673–80. DOI:10.1042/0264-6021:3450673. PMID 10642527.
  • Sapkota GP, Kieloch A, Lizcano JM, et al.. (2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.". J. Biol. Chem. 276 (22): 19469–82. DOI:10.1074/jbc.M009953200. PMID 11297520.
  • Karuman P, Gozani O, Odze RD, et al.. (2001). "The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.". Mol. Cell 7 (6): 1307–19. DOI:10.1016/S1097-2765(01)00258-1. PMID 11430832.
  • Marignani PA, Kanai F, Carpenter CL. (2001). "LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest.". J. Biol. Chem. 276 (35): 32415–8. DOI:10.1074/jbc.C100207200. PMID 11445556.
  • Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, Westra WH, Herman JG, Sidransky D. (2002). "Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.". Cancer Res. 62 (13): 3659–62. PMID 12097271.
  • Abed AA, Günther K, Kraus C, et al.. (2002). "Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4).". Hum. Mutat. 18 (5): 397–410. DOI:10.1002/humu.1211. PMID 11668633.
  • Sato N, Rosty C, Jansen M, et al.. (2001). "STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas.". Am. J. Pathol. 159 (6): 2017–22. PMID 11733352.