Álcool desidrogenase 4
(Redirecionado de ADH4)
| editar |
Álcool desidrogenase 4 é uma enzima que nos humanos é codificada pelo gene ADH4.[1]
Este gene codifica a subunidade pi da álcool desidrogenase 4 classe II, que é um dos membros da família das álcool desidrogenases. Os membros desta família de enzimas metabolizam uma grande variedade de substratos, incluindo etanol, retinol, outros álcoois alifáticos, hidroesteróides e produtos da peroxidação lipídica. A álcool desidrogenase 4 de classe II é um homodímero composto de duas subunidades pi. Exibe uma actividade alta para oxidação de álcoois alifáticos de cadeia longa e álcoois aromáticos e é menos sensível ao pirazol. Este gene está localizado no cromossoma 4, no cluster de genes da álcool desidrogenase.[1]
Referências
Leitura adicional[editar | editar código-fonte]
- Jörnvall H (1994). «The alcohol dehydrogenase system.». EXS. 71: 221–9. PMID 8032153
- Edman K, Maret W (1993). «Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classes.». Hum. Genet. 90 (4): 395–401. PMID 1362387
- von Bahr-Lindström H, Jörnvall H, Höög JO (1991). «Cloning and characterization of the human ADH4 gene.». Gene. 103 (2): 269–74. PMID 1889753. doi:10.1016/0378-1119(91)90285-J
- Höög JO, von Bahr-Lindström H, Hedén LO,; et al. (1987). «Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit.». Biochemistry. 26 (7): 1926–32. PMID 3036213. doi:10.1021/bi00381a021
- Mårdh G, Dingley AL, Auld DS, Vallee BL (1987). «Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism.». Proc. Natl. Acad. Sci. U.S.A. 83 (23): 8908–12. PMC 387042
. PMID 3466164. doi:10.1073/pnas.83.23.8908 - Li M, Edenberg HJ (1998). «Function of cis-acting elements in human alcohol dehydrogenase 4 (ADH4) promoter and role of C/EBP proteins in gene expression.». DNA Cell Biol. 17 (4): 387–97. PMID 9570155. doi:10.1089/dna.1998.17.387
- Tryggvason K, Romert A, Eriksson U (2001). «Biosynthesis of 9-cis-retinoic acid in vivo. The roles of different retinol dehydrogenases and a structure-activity analysis of microsomal retinol dehydrogenases.». J. Biol. Chem. 276 (22): 19253–8. PMID 11279029. doi:10.1074/jbc.M100215200
- Xu XR, Huang J, Xu ZG,; et al. (2002). «Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.». Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. PMC 64988. PMID 11752456. doi:10.1073/pnas.241522398
- Iida A, Saito S, Sekine A,; et al. (2002). «Thirteen single-nucleotide polymorphisms (SNPs) in the alcohol dehydrogenase 4 (ADH4) gene locus.». J. Hum. Genet. 47 (2): 74–6. PMID 11916005. doi:10.1007/s100380200003
- Strömberg P, Svensson S, Hedberg JJ,; et al. (2002). «Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2.». Cell. Mol. Life Sci. 59 (3): 552–9. PMID 11964133. doi:10.1007/s00018-002-8447-1
- Chou CF, Lai CL, Chang YC,; et al. (2002). «Kinetic mechanism of human class IV alcohol dehydrogenase functioning as retinol dehydrogenase.». J. Biol. Chem. 277 (28): 25209–16. PMID 11997393. doi:10.1074/jbc.M201947200
- Strausberg RL, Feingold EA, Grouse LH,; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- Galter D, Carmine A, Buervenich S,; et al. (2003). «Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain.». Eur. J. Biochem. 270 (6): 1316–26. PMID 12631290. doi:10.1046/j.1432-1033.2003.03502.x
- Neumark YD, Friedlander Y, Durst R,; et al. (2004). «Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population.». Alcohol. Clin. Exp. Res. 28 (1): 10–4. PMID 14745297. doi:10.1097/01.ALC.0000108667.79219.4D
- Gerhard DS, Wagner L, Feingold EA,; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- Luo X, Kranzler HR, Zuo L,; et al. (2006). «ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies.». Pharmacogenet. Genomics. 15 (11): 755–68. PMID 16220108. doi:10.1097/01.fpc.0000180141.77036.dc
- Luo X, Kranzler HR, Zuo L,; et al. (2006). «ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies.». Neuropsychopharmacology. 31 (5): 1085–95. PMID 16237392. doi:10.1038/sj.npp.1300925
- Luo X, Kranzler HR, Zuo L,; et al. (2007). «Personality traits of agreeableness and extraversion are associated with ADH4 variation.». Biol. Psychiatry. 61 (5): 599–608. PMC 1853245. PMID 17069770. doi:10.1016/j.biopsych.2006.05.017
