APBB1IP
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| APBB1IP | |||||||||||||
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| Identificadores | |||||||||||||
| Símbolos | APBB1IP; INAG1; PREL1; RARP1; RIAM | ||||||||||||
| IDs externos | OMIM: 609036 MGI: 1861354 HomoloGene: 32434 GeneCards: APBB1IP Gene | ||||||||||||
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| Ortólogos | |||||||||||||
| Espécies | Humano | Rato | |||||||||||
| Entrez | 54518 | 54519 | |||||||||||
| Ensembl | ENSG00000077420 | ENSMUSG00000026786 | |||||||||||
| UniProt | Q7Z5R6 | Q8R5A3 | |||||||||||
| RefSeq (mRNA) | NM_019043.3 | NM_019456.2 | |||||||||||
| RefSeq (proteína) | NP_061916.3 | NP_062329.2 | |||||||||||
| Localização (UCSC) |
Chr 10: 26.73 – 26.86 Mb |
Chr 2: 22.77 – 22.88 Mb | |||||||||||
| Busca PubMed | [1] | [2] | |||||||||||
APBB1IP (do inglês: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, também denominado APBB1-interacting protein 1 ou Rap1-GTP-interacting adapter molecule (RIAM)) é uma proteína que nos humanos é codificada pelo gene com o mesmo nome.[1][2][3]
Referências
- ↑ «Entrez Gene: amyloid beta (A4) precursor protein-binding»
- ↑ Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K (dezembro de 2003). «The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells». J. Biol. Chem. 278 (51): 51685–92. PMID 14530287. doi:10.1074/jbc.M308016200
- ↑ Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA (outubro de 2004). «RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion». Dev. Cell. 7 (4): 585–95. PMID 15469846. doi:10.1016/j.devcel.2004.07.021
Leitura adicional[editar | editar código-fonte]
- Lee HS, Lim CJ, Puzon-McLaughlin W,; et al. (2009). «RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences.». J. Biol. Chem. 284 (8): 5119–27. PMID 19098287. doi:10.1074/jbc.M807117200
- Ermekova KS, Zambrano N, Linn H,; et al. (1997). «The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.». J. Biol. Chem. 272 (52): 32869–77. PMID 9407065. doi:10.1074/jbc.272.52.32869
- Rose JE, Behm FM, Drgon T,; et al. «Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.». Mol. Med. 16 (7-8): 247–53. PMC 2896464
. PMID 20379614. doi:10.2119/molmed.2009.00159 - Morgan AR, Turic D, Jehu L,; et al. (2007). «Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.». Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (6): 762–70. PMID 17373700. doi:10.1002/ajmg.b.30509
- Gerhard DS, Wagner L, Feingold EA,; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- Jenzora A, Behrendt B, Small JV,; et al. (2005). «PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins.». FEBS Lett. 579 (2): 455–63. PMID 15642358. doi:10.1016/j.febslet.2004.10.110
- Grupe A, Li Y, Rowland C,; et al. (2006). «A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.». Am. J. Hum. Genet. 78 (1): 78–88. PMC 1380225. PMID 16385451. doi:10.1086/498851
- Strausberg RL, Feingold EA, Grouse LH,; et al. (2002). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- Patsoukis N, Lafuente EM, Meraner P,; et al. (2009). «RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells.». Sci Signal. 2 (99): ra79. PMID 19952372. doi:10.1126/scisignal.2000409
- Deloukas P, Earthrowl ME, Grafham DV,; et al. (2004). «The DNA sequence and comparative analysis of human chromosome 10.». Nature. 429 (6990): 375–81. PMID 15164054. doi:10.1038/nature02462
- Linkermann A, Gelhaus C, Lettau M,; et al. (2009). «Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.». Biochim. Biophys. Acta. 1794 (2): 168–76. PMID 19041431. doi:10.1016/j.bbapap.2008.10.013
- Defilippi P, Di Stefano P, Cabodi S (2006). «p130Cas: a versatile scaffold in signaling networks.». Trends Cell Biol. 16 (5): 257–63. PMID 16581250. doi:10.1016/j.tcb.2006.03.003
- Shattil SJ (2005). «Integrins and Src: dynamic duo of adhesion signaling.». Trends Cell Biol. 15 (8): 399–403. PMID 16005629. doi:10.1016/j.tcb.2005.06.005
