CXCR4

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CXCR-4 (C-X-C chemokine receptor type 4) ou CD184 (cluster of differentiation 184) é uma proteína que nos humanos é codificada pelo gene CXCR4.[1][2]

Técnica CRISPR[editar | editar código-fonte]

Usando CRISPR, pesquisadores foram capazes de converter a proteína CXCR4 na superfície das células T do sistema imunológico, de uma forma que as células geneticamente modificadas não eram mais propensas a ataques pelo vírus HIV.[3].

Referências

  1. Moriuchi M, Moriuchi H, Turner W, Fauci AS (1997). «Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry»: 4322–9. PMID 9379028 
  2. Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (1998). «Genomic organization and promoter characterization of human CXCR4 gene»: 271–8. PMID 9599023 
  3. «Breakthrough announced in 'editing' DNA to fight off deadly illness». Consultado em 2015-07-30 

Leitura de apoio[editar | editar código-fonte]

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  • Freedman BD, Liu QH, Del Corno M, Collman RG (2004). «HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages.»: 261–76. doi:10.1385/IR:27:2-3:261. PMID 12857973 
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  • Gallo SA, Finnegan CM, Viard M; et al. (2003). «The HIV Env-mediated fusion reaction.»: 36–50. doi:10.1016/S0005-2736(03)00161-5. PMID 12873764 
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  • Yi Y, Lee C, Liu QH; et al. (2004). «Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis.»: 91–6. PMID 14982745 
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  • Perfettini JL, Castedo M, Roumier T; et al. (2006). «Mechanisms of apoptosis induction by the HIV-1 envelope.»: 916–23. doi:10.1038/sj.cdd.4401584. PMID 15719026 
  • King JE, Eugenin EA, Buckner CM, Berman JW (2006). «HIV tat and neurotoxicity.»: 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675 
  • Kryczek I, Wei S, Keller E; et al. (2007). «Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis.»: C987–95. doi:10.1152/ajpcell.00406.2006. PMID 16943240 
  • Arya M, Ahmed H, Silhi N; et al. (2007). «Clinical importance and therapeutic implications of the pivotal CXCL12-CXCR4 (chemokine ligand-receptor) interaction in cancer cell migration.»: 123–31. doi:10.1159/000102979. PMID 17510563 
  • Grange JM (1980). «Tuberculosis: the changing tubercle.»: 540–8. PMID 118789 
  • Nomura H, Nielsen BW, Matsushima K (1994). «Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.»: 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609 
  • Lu ZH, Wang ZX, Horuk R; et al. (1995). «The promiscuous chemokine binding profile of the Duffy antigen/receptor for chemokines is primarily localized to sequences in the amino-terminal domain.»: 26239–45. doi:10.1074/jbc.270.44.26239. PMID 7592830 
  • Jazin EE, Yoo H, Blomqvist AG; et al. (1993). «A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells.»: 247–58. doi:10.1016/0167-0115(93)90392-L. PMID 8234909 
  • Loetscher M, Geiser T, O'Reilly T; et al. (1994). «Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes.»: 232–7. PMID 8276799 
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