Desmogleína 1

Desmogleína 1
Identificadores
Símbolos	DSG1; CDHF4; DG1; DSG; EPKHE; EPKHIA; PPKS1; SPPK1
IDs externos	OMIM: 125670 MGI: 94930 HomoloGene: 1463 GeneCards: DSG1 Gene
Ontologia do gene
Função molecular	•calcium ion binding; •toxic substance binding; •gamma-catenin binding;
Componente celular	•cytosol; •plasma membrane; •cell-cell junction; •cytoplasmic side of plasma membrane; •integral component of membrane; •apical plasma membrane; •lateral plasma membrane; •desmosome; •extracellular vesicular exosome;
Processo biológico	•apoptotic process; •cellular component disassembly involved in execution phase of apoptosis; •cell-cell junction assembly; •homophilic cell adhesion; •single organismal cell-cell adhesion; •calcium-dependent cell-cell adhesion; •response to progesterone; •protein stabilization; •maternal process involved in female pregnancy;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

A desmogleína 1 é uma proteína que nos humanos é codificada pelo gene DSG1.^[1]^[2]

Função

Os desmossomas são junções célula-célula entre vários tipos de células, como células do epitélio e células do miocárdio. A desmogleína 1 é uma glicoproteína transmembranar ligada a cálcio, componente dos desmossomas em células epiteliais de vertebrados. Actualmente, 4 membros da subfamília da desmogleína foram identificados e são todos membros da superfamília das moléculas de adesão celular (caderinas). OS membros desta subfamília de genes estão localizados num agregado no cromossoma 18. A proteína codificada por este gene foi identificada como o auto-antigénio da doença auto-imune da pele, pênfigo foliáceo.^[2]

Interacões

A desmogleína 1 foi demonstrada interagir com PKP3,^[3] PKP2,^[4] e PTPRT (PTPrho)^[5]

Ver também

Desmogleína

Referências

↑ Arnemann J, Spurr NK, Wheeler GN, Parker AE, Buxton RS (outubro de 1991). «Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)». Genomics. 10 (3): 640–5. PMID 1889810. doi:10.1016/0888-7543(91)90446-L
↑ ^a ^b «Entrez Gene: DSG1 desmoglein 1»
↑ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (abril de 2003). «Defining desmosomal plakophilin-3 interactions». J. Cell Biol. 161 (2): 403–16. PMC 2172904. PMID 12707304. doi:10.1083/jcb.200303036
↑ Chen X, Bonne S, Hatzfeld M, van Roy F, Green KJ (março de 2002). «Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling». J. Biol. Chem. 277 (12): 10512–22. PMID 11790773. doi:10.1074/jbc.M108765200
↑ Besco JA, Hooft van Huijsduijnen R, Frostholm A, Rotter A (2006). «Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT).». Brain Res. 1116 (1): 50–7. PMID 16973135. doi:10.1016/j.brainres.2006.07.122

Leitura adicional

Amagai M (2003). «Desmoglein as a target in autoimmunity and infection». J. Am. Acad. Dermatol. 48 (2): 244–52. PMID 12582396. doi:10.1067/mjd.2003.7
Wheeler GN, Parker AE, Thomas CL (1991). «Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules». Proc. Natl. Acad. Sci. U.S.A. 88 (11): 4796–800. PMC 51753. PMID 1711210. doi:10.1073/pnas.88.11.4796
Amagai M, Klaus-Kovtun V, Stanley JR (1992). «Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion». Cell. 67 (5): 869–77. PMID 1720352. doi:10.1016/0092-8674(91)90360-B
Martínez RD (1992). «[Characterization of the desmoglein in renal cells in culture]» [Characterization of the desmoglein in renal cells in culture]. Revista alergia México (em espanhol). 38 (2): 59–64. PMID 1754823
Nilles LA, Parry DA, Powers EE (1992). «Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome». J. Cell. Sci. 99 (4): 809–21. PMID 1770008
Roh JY, Stanley JR (1995). «Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment». J. Invest. Dermatol. 104 (5): 720–4. PMID 7738346. doi:10.1111/1523-1747.ep12606963
Simrak D, Cowley CM, Buxton RS, Arnemann J (1995). «Tandem arrangement of the closely linked desmoglein genes on human chromosome 18». Genomics. 25 (2): 591–4. PMID 7790000. doi:10.1016/0888-7543(95)80067-V
Wang Y, Amagai M, Minoshima S (1994). «The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12». Genomics. 20 (3): 492–5. PMID 8034325. doi:10.1006/geno.1994.1207
Schäfer S, Koch PJ, Franke WW (1994). «Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins». Exp. Cell Res. 211 (2): 391–9. PMID 8143788. doi:10.1006/excr.1994.1103
Adams MJ, Reichel MB, King IA (1998). «Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens». Biochem. J. 329 (Pt 1): 165–74. PMC 1219028. PMID 9405290
Marcozzi C, Burdett ID, Buxton RS, Magee AI (1998). «Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion». J. Cell. Sci. 111 (4): 495–509. PMID 9443898
Smith EA, Fuchs E (1998). «Defining the Interactions Between Intermediate Filaments and Desmosomes». J. Cell Biol. 141 (5): 1229–41. PMC 2137181. PMID 9606214. doi:10.1083/jcb.141.5.1229
Rickman L, Simrak D, Stevens HP (1999). «N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma». Hum. Mol. Genet. 8 (6): 971–6. PMID 10332028. doi:10.1093/hmg/8.6.971
Li G, Schaider H, Satyamoorthy K (2002). «Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development». Oncogene. 20 (56): 8125–35. PMID 11781826. doi:10.1038/sj.onc.1205034
Chen X, Bonne S, Hatzfeld M (2002). «Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling». J. Biol. Chem. 277 (12): 10512–22. PMID 11790773. doi:10.1074/jbc.M108765200
Martel P, Gilbert D, Busson M (2003). «Epistasis between DSG1 and HLA class II genes in pemphigus foliaceus». Genes Immun. 3 (4): 205–10. PMID 12058255. doi:10.1038/sj.gene.6363839
Hanakawa Y, Schechter NM, Lin C (2002). «Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome». J. Clin. Invest. 110 (1): 53–60. PMC 151035. PMID 12093888. doi:10.1172/JCI15766
Hanakawa Y, Amagai M, Shirakata Y (2003). «Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation». J. Invest. Dermatol. 119 (6): 1231–6. PMID 12485422. doi:10.1046/j.1523-1747.2002.19648.x

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[pmid1889810-1] Arnemann J, Spurr NK, Wheeler GN, Parker AE, Buxton RS (outubro de 1991). «Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)». Genomics. 10 (3): 640–5. PMID 1889810. doi:10.1016/0888-7543(91)90446-L

[entrez-2] «Entrez Gene: DSG1 desmoglein 1»

[pmid12707304-3] Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (abril de 2003). «Defining desmosomal plakophilin-3 interactions». J. Cell Biol. 161 (2): 403–16. PMC 2172904. PMID 12707304. doi:10.1083/jcb.200303036

[pmid11790773-4] Chen X, Bonne S, Hatzfeld M, van Roy F, Green KJ (março de 2002). «Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling». J. Biol. Chem. 277 (12): 10512–22. PMID 11790773. doi:10.1074/jbc.M108765200

[pmid16973135-5] Besco JA, Hooft van Huijsduijnen R, Frostholm A, Rotter A (2006). «Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT).». Brain Res. 1116 (1): 50–7. PMID 16973135. doi:10.1016/j.brainres.2006.07.122

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