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Origin recognition complex, subunit 5-like (yeast)
Símbolo ORC5L
Entrez 5001
OMIM 602331
RefSeq NP_002544
UniProt O43913
Outros dados
Locus Cr. 7 [1]

Origin recognition complex, subunit 5-like (yeast) também conhecido como ORC5L, é uma proteína que em humanos é codificada pelo gene ORC5L.[1]

Interações[editar | editar código-fonte]

ORC5L mostrou interação com ORC1L,[2] ORC2L,[2][3][4][5] MCM7,[2] ORC4L,[2][3][4] ORC3L,[2][4][5][6] MCM2,[2] MCM4[2] e MCM3.[2]


  1. «Entrez Gene: ORC5L origin recognition complex, subunit 5-like (yeast)» 
  2. a b c d e f g h Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). «Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells»: 111–28. ISSN 0022-2836. PMID 12614612 
  3. a b Quintana, D G; Thome K C, Hou Z H, Ligon A H, Morton C C, Dutta A (Oct. 1998). «ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases»: 27137–45. ISSN 0021-9258. PMID 9765232 
  4. a b c Dhar, S K; Delmolino L, Dutta A (Aug. 2001). «Architecture of the human origin recognition complex»: 29067–71. doi:10.1074/jbc.M103078200. ISSN 0021-9258. PMID 11395502 
  5. a b Vashee, S; Simancek P, Challberg M D, Kelly T J (Jul. 2001). «Assembly of the human origin recognition complex»: 26666–73. doi:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433 
  6. Pinto, S; Quintana D G, Smith P, Mihalek R M, Hou Z H, Boynton S, Jones C J, Hendricks M, Velinzon K, Wohlschlegel J A, Austin R J, Lane W S, Tully T, Dutta A (May. 1999). «latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant»: 45–54. ISSN 0896-6273. PMID 10402184 

Leitura de apoio[editar | editar código-fonte]

  • Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.»: 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298 
  • Klemm RD, Austin RJ, Bell SP (1997). «Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.»: 493–502. doi:10.1016/S0092-8674(00)81889-9. PMID 9038340 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.»: 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149 
  • Ishiai M, Dean FB, Okumura K; et al. (1998). «Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22.»: 294–8. doi:10.1006/geno.1997.5003. PMID 9417919 
  • Quintana DG, Thome KC, Hou ZH; et al. (1998). «ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.»: 27137–45. doi:10.1074/jbc.273.42.27137. PMID 9765232 
  • Tugal T, Zou-Yang XH, Gavin K; et al. (1999). «The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p.»: 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972 
  • Jiang W, McDonald D, Hope TJ, Hunter T (1999). «Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.»: 5703–13. doi:10.1093/emboj/18.20.5703. PMID 10523313 
  • Thome KC, Dhar SK, Quintana DG; et al. (2001). «Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins.»: 35233–41. doi:10.1074/jbc.M005765200. PMID 10954718 
  • Vashee S, Simancek P, Challberg MD, Kelly TJ (2001). «Assembly of the human origin recognition complex.»: 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433 
  • Fröhling S, Nakabayashi K, Scherer SW; et al. (2001). «Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22.»: 304–9. doi:10.1007/s004390100498. PMID 11379876 
  • Dhar SK, Delmolino L, Dutta A (2001). «Architecture of the human origin recognition complex.»: 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.»: 16899–903. doi:10.1073/pnas.242603899. PMID 12477932 
  • Kneissl M, Pütter V, Szalay AA, Grummt F (2003). «Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.»: 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612 
  • Scherer SW, Cheung J, MacDonald JR; et al. (2003). «Human chromosome 7: DNA sequence and biology.»: 767–72. doi:10.1126/science.1083423. PMID 12690205 
  • Hillier LW, Fulton RS, Fulton LA; et al. (2003). «The DNA sequence of human chromosome 7.»: 157–64. doi:10.1038/nature01782. PMID 12853948 
  • Ramachandran N, Hainsworth E, Bhullar B; et al. (2004). «Self-assembling protein microarrays.»: 86–90. doi:10.1126/science.1097639. PMID 15232106 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).»: 2121–7. doi:10.1101/gr.2596504. PMID 15489334 

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