Catecol O-Metiltransferase: diferenças entre revisões

COMT
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD
Identificadores
Nomes alternativos	COMT
IDs externos	OMIM: 116790 HomoloGene: 30982 GeneCards: COMT
Targeted by Drug
	entacapone, tolcapona, Viroporin 3a
Ontologia genética
Função molecular	• transferase activity; • O-methyltransferase activity; • metal ion binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • magnesium ion binding; • catechol O-methyltransferase activity; • GO:0102674, GO:0102675 methyltransferase activity; • L-dopa O-methyltransferase activity; • orcinol O-methyltransferase activity;
Componente celular	• citoplasma; • integral component of membrane; • corpo celular; • citosol; • postsynaptic membrane; • membrane; • membrana plasmática; • Espinha dendrítica; • axónio; • dendrito; • mitocôndria; • Exossoma; • intracellular membrane-bounded organelle;
Processo biológico	• multicellular organismal reproductive process; • negative regulation of smooth muscle cell proliferation; • GO:1904578 response to organic cyclic compound; • regulation of sensory perception of pain; • estrogen metabolic process; • cellular response to phosphate starvation; • catechol-containing compound metabolic process; • female pregnancy; • negative regulation of dopamine metabolic process; • GO:0007571 developmental process; • aprendizagem; • catecholamine metabolic process; • neurotransmitter catabolic process; • response to lipopolysaccharide; • metilação; • dopamine metabolic process; • response to pain; • memória a curto prazo; • negative regulation of renal sodium excretion; • dopamine catabolic process; • positive regulation of homocysteine metabolic process; • catecholamine catabolic process; • response to estrogen;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	; ; ; ;
	Mais dados de referência de expressão
Ortólogos
	1312
	n/a
	ENSG00000093010
	n/a
	P21964
	n/a
	NM_000754; NM_001135161; NM_001135162; NM_007310; NM_001362828
	n/a
	NP_000745; NP_001128633; NP_001128634; NP_009294; NP_001349757
	n/a
	Wikidata
Ver/Editar Humano

Explorar interativamente o histórico

← Ver a alteração anterior Ver a alteração posterior →

Conteúdo apagado Conteúdo adicionado

VisualTexto wiki

Em linha

Revisão das 21h31min de 31 de outubro de 2019

A Catecol O-Metiltransferase, ou simplesmente COMT, é uma das muitas enzimas que degradam catecolaminas (dopamina, epinefrina e norepinefrina).^[3]

Referências

↑ «Drogas que interagem fisicamente com Catechol-O-methyltransferase ver/editar referências no wikidata»
↑ «Human PubMed Reference:»
↑ «Test ID: COMT: Catechol-O-Methyltransferase Genotype». www.mayomedicallaboratories.com. Mayo Clinic: Mayo Medical Laboratories. Consultado em November 16, 2016. Cópia arquivada em September 18, 2008 Verifique data em: |acessodata=, |arquivodata= (ajuda)

Este artigo sobre medicina é um esboço. Você pode ajudar a Wikipédia expandindo-o.

Leitura adicional

Trendelenburg U (1991). «The interaction of transport mechanisms and intracellular enzymes in metabolizing systems». Journal of Neural Transmission. Supplementum. 32: 3–18. ISBN 978-3-211-82239-5. PMID 2089098. doi:10.1007/978-3-7091-9113-2_1
Zhu BT (October 2002). «On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis». Histology and Histopathology. 17 (4): 1283–91. PMID 12371153 Verifique data em: |data= (ajuda)
Oroszi G, Goldman D (December 2004). «Alcoholism: genes and mechanisms». Pharmacogenomics. 5 (8): 1037–48. PMID 15584875. doi:10.1517/14622416.5.8.1037 Verifique data em: |data= (ajuda)
Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L (January 2005). «Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis». Biological Psychiatry. 57 (2): 139–44. PMID 15652872. doi:10.1016/j.biopsych.2004.10.018 Verifique data em: |data= (ajuda)
Tunbridge EM, Harrison PJ, Weinberger DR (July 2006). «Catechol-O-methyltransferase, cognition, and psychosis: Val¹⁵⁸Met and beyond». Biological Psychiatry. 60 (2): 141–51. PMID 16476412. doi:10.1016/j.biopsych.2005.10.024 Verifique data em: |data= (ajuda)
Craddock N, Owen MJ, O'Donovan MC (May 2006). «The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons». Molecular Psychiatry. 11 (5): 446–58. PMID 16505837. doi:10.1038/sj.mp.4001808 Verifique data em: |data= (ajuda)
Frank MJ, Moustafa AA, Haughey HM, Curran T, Hutchison KE (October 2007). «Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning». Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16311–6. PMC 2042203. PMID 17913879. doi:10.1073/pnas.0706111104 Verifique data em: |data= (ajuda)
Greenberg, Gary (November 7, 2018). «What If the Placebo Effect Isn't a Trick?». New York Times Magazine Verifique data em: |data= (ajuda)

[1] «Drogas que interagem fisicamente com Catechol-O-methyltransferase ver/editar referências no wikidata»

[2] «Human PubMed Reference:»

[3] «Test ID: COMT: Catechol-O-Methyltransferase Genotype». www.mayomedicallaboratories.com. Mayo Clinic: Mayo Medical Laboratories. Consultado em November 16, 2016. Cópia arquivada em September 18, 2008 Verifique data em: |acessodata=, |arquivodata= (ajuda)

[1]

[2]

[3]

@@ Linha 1: / Linha 1: @@
+{{#invoke:Info/Gene|getTemplateData|QID=Q14863656}}
-[[Ficheiro:Catechol-O-methyl transferase 3bwm.png|thumb|right|250px|Catecol O-Metiltransferase]]
-A '''Catecol O-Metiltransferase''', ou simplesmente '''COMT''', é uma das muitas [[enzima]]s que degradam [[catecolaminas]] ([[dopamina]], [[epinefrina]] e [[norepinefrina]]).
+A '''Catecol O-Metiltransferase''', ou simplesmente '''COMT''', é uma das muitas [[enzima]]s que degradam [[catecolaminas]] ([[dopamina]], [[epinefrina]] e [[norepinefrina]]).<ref>{{Cite web|url=http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83301|archive-url=https://web.archive.org/web/20080918012710/http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83301|url-status=dead|archive-date=September 18, 2008|title=Test ID: COMT: Catechol-''O''-Methyltransferase Genotype|website=www.mayomedicallaboratories.com|publisher=Mayo Clinic: Mayo Medical Laboratories|access-date=November 16, 2016}}</ref>
+{{referências}}
 {{Esboço-medicina}}
+==Leitura adicional==
+{{refbegin|33em}}
+* {{cite journal | vauthors = Trendelenburg U | title = The interaction of transport mechanisms and intracellular enzymes in metabolizing systems | journal = Journal of Neural Transmission. Supplementum | volume = 32 | issue =  | pages = 3–18 | year = 1991 | pmid = 2089098 | doi = 10.1007/978-3-7091-9113-2_1 | isbn = 978-3-211-82239-5 }}
+* {{cite journal | vauthors = Zhu BT | title = On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis | journal = Histology and Histopathology | volume = 17 | issue = 4 | pages = 1283–91 | date = October 2002 | pmid = 12371153 | doi =  }}
+* {{cite journal | vauthors = Oroszi G, Goldman D | title = Alcoholism: genes and mechanisms | journal = Pharmacogenomics | volume = 5 | issue = 8 | pages = 1037–48 | date = December 2004 | pmid = 15584875 | doi = 10.1517/14622416.5.8.1037 }}
+* {{cite journal | vauthors = Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L | title = Catechol-''O''-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis | journal = Biological Psychiatry | volume = 57 | issue = 2 | pages = 139–44 | date = January 2005 | pmid = 15652872 | doi = 10.1016/j.biopsych.2004.10.018 }}
+* {{cite journal | vauthors = Tunbridge EM, Harrison PJ, Weinberger DR | title = Catechol-''O''-methyltransferase, cognition, and psychosis: Val<sup>158</sup>Met and beyond | journal = Biological Psychiatry | volume = 60 | issue = 2 | pages = 141–51 | date = July 2006 | pmid = 16476412 | doi = 10.1016/j.biopsych.2005.10.024 }}
+* {{cite journal | vauthors = Craddock N, Owen MJ, O'Donovan MC | title = The catechol-''O''-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons | journal = Molecular Psychiatry | volume = 11 | issue = 5 | pages = 446–58 | date = May 2006 | pmid = 16505837 | doi = 10.1038/sj.mp.4001808 }}
+* {{cite journal | vauthors = Frank MJ, Moustafa AA, Haughey HM, Curran T, Hutchison KE | title = Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 41 | pages = 16311–6 | date = October 2007 | pmid = 17913879 | pmc = 2042203 | doi = 10.1073/pnas.0706111104 }}
+* {{cite journal |vauthors= Greenberg, Gary |title= What If the Placebo Effect Isn't a Trick? |journal= New York Times Magazine |date= November 7, 2018}}
+{{refend}}
 [[Categoria:Transferases]]