NOD2

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NOD2 (em inglês: nucleotide-binding oligomerization domain containing 2) é uma proteína que desempenha um importante papel no sistema imune.

Em 2009, pesquisadores da Universidade do Texas, publicaram na revista científica Nature Immunology, que esta proteína organiza a defesa contra vários tipos de gripe, inclusive a causada pelo vírus H1N1.[1]

Notas e referências

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  • Punchard NA. (2002). "Overview: Nod2, cause of, or contributor to, Crohn's disease.". Current opinion in investigational drugs (London, England : 2000) 2 (10): 1378–81. PMID 11890351.
  • Satsangi J, Morecroft J, Shah NB, Nimmo E. (2003). "Genetics of inflammatory bowel disease: scientific and clinical implications.". Best practice & research. Clinical gastroenterology 17 (1): 3–18. DOI:10.1053/bega.2002.0349. PMID 12617879.
  • Rosenbaum JT, Planck SR, Davey MP, et al.. (2003). "With a mere nod, uveitis enters a new era.". Am. J. Ophthalmol. 136 (4): 729–32. DOI:10.1016/S0002-9394(03)00569-5. PMID 14516815.
  • Kurokawa T, Kikuchi T, Ohta K, et al.. (2003). "Ocular manifestations in Blau syndrome associated with a CARD15/Nod2 mutation.". Ophthalmology 110 (10): 2040–4. DOI:10.1016/S0161-6420(03)00717-6. PMID 14522785.
  • Girardin SE, Hugot JP, Sansonetti PJ. (2004). "Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing.". Trends Immunol. 24 (12): 652–8. DOI:10.1016/j.it.2003.10.007. PMID 14644139.
  • Newman B, Siminovitch K. (2004). "Inflammatory bowel disease: Crohn's disease and the success of NODern genetics.". Clinical and investigative medicine. Médecine clinique et experimentale 26 (6): 303–14. PMID 14690304.
  • Oostenbrug LE, van Dullemen HM, te Meerman GJ, Jansen PL. (2004). "IBD and genetics: new developments.". Scand. J. Gastroenterol. Suppl. (239): 63–8. PMID 14743885.
  • Kambe N, Nishikomori R, Kanazawa N. (2005). "The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders.". J. Dermatol. Sci. 39 (2): 71–80. DOI:10.1016/j.jdermsci.2005.04.001. PMID 15927452.
  • Newman B, Siminovitch KA. (2005). "Recent advances in the genetics of inflammatory bowel disease.". Curr. Opin. Gastroenterol. 21 (4): 401–7. PMID 15930978.
  • Martinon F, Tschopp J. (2006). "NLRs join TLRs as innate sensors of pathogens.". Trends Immunol. 26 (8): 447–54. DOI:10.1016/j.it.2005.06.004. PMID 15967716.
  • Strober W, Murray PJ, Kitani A, Watanabe T. (2006). "Signalling pathways and molecular interactions of NOD1 and NOD2.". Nat. Rev. Immunol. 6 (1): 9–20. DOI:10.1038/nri1747. PMID 16493424.
  • Cavanaugh J. (2006). "NOD2: ethnic and geographic differences.". World J. Gastroenterol. 12 (23): 3673–7. PMID 16773683.
  • Hugot JP. (2006). "CARD15/NOD2 mutations in Crohn's disease.". Ann. N. Y. Acad. Sci. 1072: 9–18. DOI:10.1196/annals.1326.011. PMID 17057186.
  • Vignal C, Singer E, Peyrin-Biroulet L, et al.. (2007). "How NOD2 mutations predispose to Crohn's disease?". Microbes Infect. 9 (5): 658–63. DOI:10.1016/j.micinf.2007.01.016. PMID 17379562.
  • Quaglietta L, te Velde A, Staiano A, et al.. (2007). "Functional consequences of NOD2/CARD15 mutations in Crohn disease.". J. Pediatr. Gastroenterol. Nutr. 44 (5): 529–39. DOI:10.1097/MPG.0b013e31803815ee. PMID 17460484.
  • van der Linde K, Boor PP, Houwing-Duistermaat JJ, et al.. (2007). "CARD15 mutations in Dutch familial and sporadic inflammatory bowel disease and an overview of European studies.". European journal of gastroenterology & hepatology 19 (6): 449–59. DOI:10.1097/01.meg.0000236887.44214.6a. PMID 17489054.
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