Predefinição:PBB/834

Caspase 1, apoptosis-related cysteine peptidase
Renderização PDB baseada em 1bmq.
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7
Identificadores
Símbolos	CASP1; ICE; IL1BC; P45
IDs externos	OMIM: 147678 MGI: 96544 HomoloGene: 133272 ChEMBL: 4801 GeneCards: CASP1 Gene
Número EC	3.4.22.36
Ontologia do gene Função molecular •endopeptidase activity •cysteine-type endopeptidase activity •protein binding •cysteine-type endopeptidase activator activity involved in apoptotic process Componente celular •extracellular region •cytoplasm •cytosol •IPAF inflammasome complex •NLRP1 inflammasome complex •NLRP3 inflammasome complex •AIM2 inflammasome complex Processo biológico •response to hypoxia •proteolysis •apoptotic process •activation of cysteine-type endopeptidase activity involved in apoptotic process •signal transduction •response to lipopolysaccharide •interleukin-1 beta production •response to ATP •nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway •positive regulation of I-kappaB kinase/NF-kappaB signaling •innate immune response •positive regulation of interleukin-1 alpha secretion •positive regulation of interleukin-1 beta secretion •regulation of inflammatory response •mitochondrial depolarization •membrane hyperpolarization •pyroptosis •cellular response to mechanical stimulus •cellular response to organic substance •execution phase of apoptosis Sources: Amigo / QuickGO
Ortólogos
Espécies	Humano	Rato
Entrez	834	12362
Ensembl	ENSG00000137752	ENSMUSG00000025888
UniProt	P29466	P29452
RefSeq (mRNA)	NM_001223	NM_009807
RefSeq (proteína)	NP_001214	NP_033937
Localização (UCSC)	Chr 11: 104.9 – 104.97 Mb	Chr 9: 5.3 – 5.31 Mb
Busca PubMed	[1]	[2]