Predefinição:PBB/836

Caspase 3, apoptosis-related cysteine peptidase
Renderização PDB baseado em 1rhk.
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M, 2C2O, 2CDR, 2CJX, 2CJY, 2CNK, 2CNL, 2CNN, 2CNO, 2DKO, 2H5I, 2H5J, 2H65, 2J30, 2J31, 2J32, 2J33, 2XYG, 2XYH, 2XYP, 2XZD, 2XZT, 2Y0B, 3DEH, 3DEI, 3DEJ, 3DEK, 3EDQ, 3GJQ, 3GJR, 3GJS, 3GJT, 3H0E, 3ITN, 3KJF, 3PCX, 3PD0, 3PD1, 4DCJ, 4DCO, 4DCP, 4EHA, 4EHD, 4EHF, 4EHH, 4EHK, 4EHL, 4EHN, 4JJE, 4JQY, 4JQZ, 4JR0
Identificadores
Símbolos	CASP3; CPP32; CPP32B; SCA-1
IDs externos	OMIM: 600636 MGI: 107739 HomoloGene: 37912 ChEMBL: 2334 GeneCards: CASP3 Gene
Número EC	3.4.22.56
Ontologia do gene Função molecular •aspartic-type endopeptidase activity •cysteine-type endopeptidase activity •cyclin-dependent protein serine/threonine kinase inhibitor activity •protein binding •peptidase activity •cysteine-type endopeptidase activity involved in apoptotic process •cysteine-type endopeptidase activity involved in execution phase of apoptosis Componente celular •nucleus •nucleoplasm •cytosol •plasma membrane Processo biológico •B cell homeostasis •release of cytochrome c from mitochondria •apoptotic DNA fragmentation •proteolysis •apoptotic process •cellular component disassembly involved in execution phase of apoptosis •cellular response to DNA damage stimulus •heart development •sensory perception of sound •extrinsic apoptotic signaling pathway via death domain receptors •intrinsic apoptotic signaling pathway in response to oxidative stress •activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c •response to UV •response to wounding •extracellular matrix disassembly •neuron differentiation •extracellular matrix organization •keratinocyte differentiation •erythrocyte differentiation •platelet formation •negative regulation of B cell proliferation •glial cell apoptotic process •response to tumor necrosis factor •hippo signaling •regulation of apoptotic process •T cell homeostasis •positive regulation of apoptotic process •negative regulation of apoptotic process •regulation of cysteine-type endopeptidase activity involved in apoptotic process •positive regulation of neuron apoptotic process •cell fate commitment •negative regulation of cyclin-dependent protein serine/threonine kinase activity •negative regulation of activated T cell proliferation •neurotrophin TRK receptor signaling pathway •neuron apoptotic process •apoptotic signaling pathway •extrinsic apoptotic signaling pathway in absence of ligand •intrinsic apoptotic signaling pathway •execution phase of apoptosis Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies	Humano	Rato
Entrez	836	12367
Ensembl	ENSG00000164305	ENSMUSG00000031628
UniProt	P42574	P70677
RefSeq (mRNA)	NM_004346	NM_001284409
RefSeq (proteína)	NP_004337	NP_001271338
Localização (UCSC)	Chr 4: 185.55 – 185.57 Mb	Chr 8: 46.62 – 46.64 Mb
Busca PubMed	[1]	[2]