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Inositol 1,4,5-trisphosphate receptor, type 2
Símbolos ITPR2; CFAP48; IP3R2
IDs externos OMIM: 600144 MGI99418 HomoloGene37593 IUPHAR: IP3R2 ChEMBL: 2512 GeneCards: ITPR2 Gene
Espécies Humano Rato
Entrez 3709 16439
Ensembl ENSG00000123104 ENSMUSG00000030287
UniProt Q14571 Q9Z329
RefSeq (mRNA) NM_002223 NM_010586
RefSeq (proteína) NP_002214 NP_034716
Localização (UCSC) Chr 12:
26.49 – 26.99 Mb
Chr 6:
146.11 – 146.5 Mb
Busca PubMed [1] [2]

ITPR2 (do inglês, inositol 1,4,5-triphosphate receptor, type 2) é uma proteína que é codificado pelo gene humano ITPR2.[1] A proteína codificada por este gene é um receptor para o inositol trifosfato e um canal de cálcio.[2]

Ver também[editar | editar código-fonte]

Referências[editar | editar código-fonte]

  1. Entrez Gene: inositol 1.
  2. Yamamoto-Hino M, Sugiyama T, Hikichi K et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels 2 (1): 9–22. PMID 8081734. 

Leitura de apoio[editar | editar código-fonte]

  • Jardín I, López JJ, Salido GM, Rosado JA (2008). "Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets.". Cell. Signal. 20 (4): 737–47. doi:10.1016/j.cellsig.2007.12.010. PMID 18249094. 
  • Wilker E, Mittleman MA, Litonjua AA et al. (2009). "Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.". Environ. Health Perspect. 117 (6): 935–40. doi:10.1289/ehp.0800279. PMID 19590686. 
  • Rosado JA, Sage SO (2001). "Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets.". Biochem. J. 356 (Pt 1): 191–8. doi:10.1042/0264-6021:3560191. PMID 11336651. 
  • van Es MA, Van Vught PW, Blauw HM et al. (2007). "ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study.". Lancet neurology 6 (10): 869–77. doi:10.1016/S1474-4422(07)70222-3. PMID 17827064. 
  • Harzheim D, Movassagh M, Foo RS et al. (2009). "Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.". Proc. Natl. Acad. Sci. U.S.A. 106 (27): 11406–11. doi:10.1073/pnas.0905485106. PMID 19549843. 
  • Rosado JA, Sage SO (2000). "Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted.". Biochem. J. 350 Pt 3: 631–5. PMID 10970773. 
  • Uhl GR, Liu QR, Drgon T et al. (2008). "Molecular genetics of successful smoking cessation: convergent genome-wide association study results.". Arch. Gen. Psychiatry 65 (6): 683–93. doi:10.1001/archpsyc.65.6.683. PMID 18519826. 
  • Chiò A, Schymick JC, Restagno G et al. (2009). "A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.". Hum. Mol. Genet. 18 (8): 1524–32. doi:10.1093/hmg/ddp059. PMID 19193627. 
  • Miyachi K, Iwai M, Asada K et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.". Mod Rheumatol 17 (2): 137–43. doi:10.1007/s10165-006-0555-6. PMID 17437169. 
  • Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Mery L, Magnino F, Schmidt K et al. (2001). "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.". FEBS Lett. 487 (3): 377–83. doi:10.1016/S0014-5793(00)02362-0. PMID 11163362. 
  • Diaz F, Bourguignon LY (2000). "Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells.". Cell Calcium 27 (6): 315–28. doi:10.1054/ceca.2000.0126. PMID 11013462. 
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. PMID 10843712. 
  • Tanimura A, Tojyo Y, Turner RJ (2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.". J. Biol. Chem. 275 (35): 27488–93. doi:10.1074/jbc.M004495200. PMID 10874040. 
  • Jurkovicova D, Sedlakova B, Lacinova L et al. (2008). "Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.". Ann. N. Y. Acad. Sci. 1148: 421–7. doi:10.1196/annals.1410.034. PMID 19120137. 
  • Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI (2002). "Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling.". J. Biol. Chem. 277 (2): 1340–8. doi:10.1074/jbc.M106609200. PMID 11694504. 
  • Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556. 
  • Tovey SC, Dedos SG, Taylor EJ et al. (2008). "Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP.". J. Cell Biol. 183 (2): 297–311. doi:10.1083/jcb.200803172. PMID 18936250. 
  • Johnson JM, Castle J, Garrett-Engele P et al. (2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.". Science 302 (5653): 2141–4. doi:10.1126/science.1090100. PMID 14684825. 

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