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PDB 1g1e.
Estruturas disponíveis
PDB Busca de ortólogos: PDBe, RCSB
Símbolos SIN3A; DKFZp434K2235; FLJ90319; KIAA0700
IDs externos OMIM: 607776 MGI107157 HomoloGene32124 GeneCards: SIN3A Gene
Espécies Humano Rato
Entrez 25942 20466
Ensembl ENSG00000169375 ENSMUSG00000042557
UniProt Q96ST3 Q60520
RefSeq (mRNA) NM_001145357 NM_001110350
RefSeq (proteína) NP_001138829 NP_001103820
Localização (UCSC) Chr 15:
75.66 – 75.75 Mb
Chr 9:
57.07 – 57.13 Mb
Busca PubMed [1] [2]

A proteína com hélices emparelhadas anfipáticas (SIN3A) é uma proteína codificada nos humanos pelo gene SIN3A.[1][2]

A proteína codificada por este gene é um regulador da transcrição. Contém domínios de hélices emparelhadas anfipáticas (PAH), que desempenham um papel importante na interacção proteína-proteína e podem mediar a repressão exercida pelo complexo Mad-Max.[3]

Interacções[editar | editar código-fonte]

Foi mostrado que SIN3A é capaz de interagir com:

Ver também[editar | editar código-fonte]


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  2. Halleck MS, Pownall S, Harder KW, Duncan AM, Jirik FR, Schlegel RA (1995). «A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3». Genomics [S.l.: s.n.] 26 (2): 403–6. doi:10.1016/0888-7543(95)80229-F. PMID 7601471. 
  3. «Entrez Gene: SIN3A SIN3 homolog A, transcription regulator (yeast)». 
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  5. a b Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I (2004). «HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations». Nat. Struct. Mol. Biol. [S.l.: s.n.] 11 (8): 738–46. doi:10.1038/nsmb798. PMID 15235594. 
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  12. You A, Tong JK, Grozinger CM, Schreiber SL (2001). «CoREST is an integral component of the CoREST- human histone deacetylase complex». Proc. Natl. Acad. Sci. U.S.A. [S.l.: s.n.] 98 (4): 1454–8. doi:10.1073/pnas.98.4.1454. PMC 29278. PMID 11171972. 
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  15. a b Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (1998). «Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex». Nature [S.l.: s.n.] 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427. 
  16. Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL (1998). «A role for histone deacetylase activity in HDAC1-mediated transcriptional repression». Proc. Natl. Acad. Sci. U.S.A. [S.l.: s.n.] 95 (7): 3519–24. doi:10.1073/pnas.95.7.3519. PMC 19868. PMID 9520398. 
  17. Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (2002). «SATB1 targets chromatin remodelling to regulate genes over long distances». Nature [S.l.: s.n.] 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985. 
  18. a b Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (2000). «Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway». Genes Dev. [S.l.: s.n.] 14 (1): 45–54. PMC 316335. PMID 10640275. 
  19. a b c d e f Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (2002). «Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)». Mol. Cell. Biol. [S.l.: s.n.] 22 (3): 835–48. doi:10.1128/MCB.22.3.835-848.2002. PMC 133546. PMID 11784859. 
  20. a b Koipally J, Georgopoulos K (2002). «Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression». J. Biol. Chem. [S.l.: s.n.] 277 (26): 23143–9. doi:10.1074/jbc.M202079200. PMID 11959865. 
  21. Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A (2003). «The histone deacetylase 9 gene encodes multiple protein isoforms». J. Biol. Chem. [S.l.: s.n.] 278 (18): 16059–72. doi:10.1074/jbc.M212935200. PMID 12590135. 
  22. Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (2003). «A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes». J. Biol. Chem. [S.l.: s.n.] 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763. 
  23. Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (1997). «Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression». Cell [S.l.: s.n.] 89 (3): 349–56. doi:10.1016/S0092-8674(00)80215-9. PMID 9150134. 
  24. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML (2004). «Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression». Mol. Cell. Biol. [S.l.: s.n.] 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. PMC 480881. PMID 15199122. 
  25. Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (2003). «Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1». Genes Dev. [S.l.: s.n.] 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868. 
  26. Koipally J, Renold A, Kim J, Georgopoulos K (1999). «Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes». EMBO J. [S.l.: s.n.] 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820. 
  27. Koipally J, Georgopoulos K (2002). «A molecular dissection of the repression circuitry of Ikaros». J. Biol. Chem. [S.l.: s.n.] 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313. 
  28. Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, Urrutia R (2001). «A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A». Mol. Cell. Biol. [S.l.: s.n.] 21 (15): 5041–9. doi:10.1128/MCB.21.15.5041-5049.2001. PMC 87230. PMID 11438660. 
  29. Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R (2002). «Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor». EMBO J. [S.l.: s.n.] 21 (10): 2451–60. doi:10.1093/emboj/21.10.2451. PMC 126002. PMID 12006497. 
  30. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (1997). «Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor». EMBO J. [S.l.: s.n.] 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233. 
  31. Brubaker K, Cowley SM, Huang K, Loo L, Yochum GS, Ayer DE, Eisenman RN, Radhakrishnan I (2000). «Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex». Cell [S.l.: s.n.] 103 (4): 655–65. doi:10.1016/S0092-8674(00)00168-9. PMID 11106735. 
  32. Ayer DE, Lawrence QA, Eisenman RN (1995). «Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3». Cell [S.l.: s.n.] 80 (5): 767–76. doi:10.1016/0092-8674(95)90355-0. PMID 7889570. 
  33. Boeke J, Ammerpohl O, Kegel S, Moehren U, Renkawitz R (2000). «The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A». J. Biol. Chem. [S.l.: s.n.] 275 (45): 34963–7. doi:10.1074/jbc.M005929200. PMID 10950960. 
  34. Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (2000). «Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3». EMBO J. [S.l.: s.n.] 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. PMC 302030. PMID 10944117. 
  35. Yang X, Zhang F, Kudlow JE (2002). «Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression». Cell [S.l.: s.n.] 110 (1): 69–80. doi:10.1016/S0092-8674(02)00810-3. PMID 12150998. 
  36. a b Yochum GS, Ayer DE (2001). «Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex». Mol. Cell. Biol. [S.l.: s.n.] 21 (13): 4110–8. doi:10.1128/MCB.21.13.4110-4118.2001. PMC 87072. PMID 11390640. 
  37. Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S (2001). «Role of PML and PML-RARalpha in Mad-mediated transcriptional repression». Mol. Cell [S.l.: s.n.] 7 (6): 1233–43. doi:10.1016/S1097-2765(01)00257-X. PMID 11430826. 
  38. Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE (1997). «Histone deacetylase activity is required for full transcriptional repression by mSin3A». Cell [S.l.: s.n.] 89 (3): 341–7. doi:10.1016/S0092-8674(00)80214-7. PMID 9150133. 
  39. a b c Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (1998). «SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex». Mol. Cell [S.l.: s.n.] 1 (7): 1021–31. doi:10.1016/S1097-2765(00)80102-1. PMID 9651585. 
  40. Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN (1998). «SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors». Mol. Cell [S.l.: s.n.] 2 (1): 33–42. doi:10.1016/S1097-2765(00)80111-2. PMID 9702189. 
  41. a b c Sif S, Saurin AJ, Imbalzano AN, Kingston RE (2001). «Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes». Genes Dev. [S.l.: s.n.] 15 (5): 603–18. doi:10.1101/gad.872801. PMC 312641. PMID 11238380. 
  42. Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (2002). «Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex». Mol. Cell. Biol. [S.l.: s.n.] 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966. 
  43. Huang S, Brandt SJ (2000). «mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor». Mol. Cell. Biol. [S.l.: s.n.] 20 (6): 2248–59. doi:10.1128/MCB.20.6.2248-2259.2000. PMC 110841. PMID 10688671. 
  44. David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (1998). «Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein». Oncogene [S.l.: s.n.] 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120. 
  45. Ward JO, McConnell MJ, Carlile GW, Pandolfi PP, Licht JD, Freedman LP (2001). «The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor». Blood [S.l.: s.n.] 98 (12): 3290–300. doi:10.1182/blood.V98.12.3290. PMID 11719366. 
  46. Wong CW, Privalsky ML (1998). «Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6». J. Biol. Chem. [S.l.: s.n.] 273 (42): 27695–702. doi:10.1074/jbc.273.42.27695. PMID 9765306. 

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