SPINK1

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SPINK1

PDB 1cgi.
Estruturas disponíveis
PDB Busca de ortólogos: PDBe, RCSB
Identificadores
Símbolos SPINK1; PCTT; PSTI; Spink3; TATI; TCP
ID externos OMIM: 167790 MGI106202 HomoloGene68300 GeneCards: SPINK1 Gene
Padrões de expressão do ARN
PBB GE SPINK1 206239 s at tn.png
Mais dados de expressão
Ortólogos
Espécies Humano Rato
Entrez 6690 20730
Ensembl ENSG00000164266 ENSMUSG00000024503
UniProt P00995 P09036
RefSeq (mRNA) NM_003122.3 NM_009258.5
RefSeq (proteína) NP_003113.2 NP_033284.1
Localização (UCSC) Chr 5:
147.2 – 147.21 Mb
Chr 18:
43.73 – 43.74 Mb
Busca PubMed [1] [2]

SPINK1 é uma proteína que em humanos é codificada pelo gene SPINK1

Está associada ao câncer de próstata.[1]

Referências

Leitura relacionada[editar | editar código-fonte]

  • Marchbank T, Freeman TC, Playford RJ. (1998). "Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair.". Digestion 59 (3): 167–74. PMID 9643675.
  • Pfützer RH, Whitcomb DC. (2002). "SPINK1 mutations are associated with multiple phenotypes.". Pancreatology 1 (5): 457–60. DOI:10.1159/000055847. PMID 12120224.
  • Schneider A. (2005). "Serine protease inhibitor kazal type 1 mutations and pancreatitis.". Clin. Lab. Med. 25 (1): 61–78. DOI:10.1016/j.cll.2004.12.005. PMID 15749232.
  • Cohn JA, Mitchell RM, Jowell PS. (2005). "The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis.". Clin. Lab. Med. 25 (1): 79–100. DOI:10.1016/j.cll.2004.12.007. PMID 15749233.
  • Kandula L, Whitcomb DC, Lowe ME. (2006). "Genetic issues in pediatric pancreatitis.". Current gastroenterology reports 8 (3): 248–53. DOI:10.1007/s11894-006-0083-8. PMID 16764792.
  • Bartelt DC, Shapanka R, Greene LJ. (1977). "The primary structure of the human pancreatic secretory trypsin inhibitor. Amino acid sequence of the reduced S-aminoethylated protein.". Arch. Biochem. Biophys. 179 (1): 189–99. DOI:10.1016/0003-9861(77)90103-5. PMID 843082.
  • Hecht HJ, Szardenings M, Collins J, Schomburg D. (1992). "Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type).". J. Mol. Biol. 225 (4): 1095–103. DOI:10.1016/0022-2836(92)90107-U. PMID 1613792.
  • Hecht HJ, Szardenings M, Collins J, Schomburg D. (1991). "Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type).". J. Mol. Biol. 220 (3): 711–22. DOI:10.1016/0022-2836(91)90112-J. PMID 1870127.
  • Freeman TC, Davies R, Calam J. (1991). "Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors.". Clin. Chim. Acta 195 (1-2): 27–39. DOI:10.1016/0009-8981(90)90191-T. PMID 2093478.
  • Kido H, Yokogoshi Y, Katunuma N. (1990). "A low-molecular-mass Kazal-type protease inhibitor isolated from rat hepatocytes is identical to rat pancreatic secretory trypsin inhibitor II. Purification and amino acid sequence.". Eur. J. Biochem. 188 (3): 501–6. DOI:10.1111/j.1432-1033.1990.tb15428.x. PMID 2110056.
  • Tomita N, Horii A, Yamamoto T, et al.. (1988). "Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissues.". FEBS Lett. 225 (1-2): 113–9. DOI:10.1016/0014-5793(87)81141-9. PMID 2961612.
  • Horii A, Kobayashi T, Tomita N, et al.. (1988). "Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene.". Biochem. Biophys. Res. Commun. 149 (2): 635–41. DOI:10.1016/0006-291X(87)90415-3. PMID 3501289.


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