Stefan Schuster

Stefan Schuster estudou Biofísica na Universidade Humboldt de Berlin de 1981 a 1986 e em 1988 concluío o doutoramento nessa mesma Universidade. Após ter ocupado vários cargos académicos em Berlim, Bordéus, Amesterdão e Maribor (Eslovénia), Stefan Schuster rumou a Jena onde é Professor de Bioinformática na Universidade Friedrich Schiller de Jena desde 2003.

Os seus temas de investigação estão relacionados com a área de Biologia teórica, em particular:

Análise de redes de sistemas enzimáticos. Stefan Schuster idealizou, desenvolveu e aplicou o conceito de modos elementares em vários estudos de redes metabólicas ^[1]^[2]^[3].
Teoria dos jogos aplicada à evolução: Ele usou a teoria de jogos no estudo de microorganismos ^[4] e sistemas bioquímicos ^[5].
Análise de controlo metabólico: Ele desenvolveu uma análise de controlo metabólico modular ^[6] e generalizou a sua abordagem a vários parâmetros ^[7].
Oscilações biológicas: Stefan Schuster estudou oscilações de cálcio ^[8]^[9] e ritmos circadianos ^[10].

Referências

↑ S. Schuster, T. Dandekar, D.A. Fell: Detection of elementary flux modes in biochemical networks: A promising tool for pathway analysis and metabolic engineering, Trends Biotechnol. 17 (1999) 53-60
↑ L.F. de Figueiredo, A. Podhorski, A. Rubio, C. Kaleta, J.E. Beasley, S. Schuster, F.J. Planes: Computing the shortest elementary flux modes in genome-scale metabolic networks. Bioinformatics 25 (2009) 3158-3165.
↑ L.F. de Figueiredo, T.I. Gossmann, M. Ziegler, S. Schuster: Pathway analysis of NAD⁺ metabolism. Biochem. J. 439 (2011) 341–348.
↑ S. Schuster, J.U. Kreft, N. Brenner, F. Wessely, G. Theißen, E. Ruppin, A. Schroeter: Cooperation and cheating in microbial exoenzyme production - Theoretical analysis for biotechnological applications. Biotechnol. J. 5 (2010) 751-758
↑ T. Pfeiffer, S. Schuster, S. Bonhoeffer: Cooperation and competition in the evolution of ATP-producing pathways. Science 292 (2001) 504-507
↑ S. Schuster, D. Kahn, H.V. Westerhoff: Modular analysis of the control of complex metabolic pathways. Biophys. Chem. 48 (1993) 1-17
↑ S. Schuster: Control analysis in terms of generalized variables characterizing metabolic systems. J. theor. Biol. 182 (1996) 259-268
↑ M. Marhl, M. Perc, S. Schuster: A minimal model for decoding of time-limited Ca²⁺ oscillations. Biophys. Chem. 120 (2006) 161-167
↑ B. Knoke, C. Bodenstein, M. Marhl, M. Perc, S. Schuster: Jensen's Inequality as a tool for explaining the effect of oscillations on the average cytosolic calcium concentration. Theory Biosci. 129 (2010) 25–38
↑ C. Bodenstein, I. Heiland and S. Schuster: Calculating activation energies for temperature compensation in circadian rhythms. Phys. Biol. 8 (2011) 056007

Ligações externas[editar | editar código-fonte]

https://web.archive.org/web/20131002091143/http://pinguin.biologie.uni-jena.de/bioinformatik/en/

http://www.jcb-jena.de/

http://gtpb.igc.gulbenkian.pt/bicourses/MPA12/

[1] S. Schuster, T. Dandekar, D.A. Fell: Detection of elementary flux modes in biochemical networks: A promising tool for pathway analysis and metabolic engineering, Trends Biotechnol. 17 (1999) 53-60

[2] L.F. de Figueiredo, A. Podhorski, A. Rubio, C. Kaleta, J.E. Beasley, S. Schuster, F.J. Planes: Computing the shortest elementary flux modes in genome-scale metabolic networks. Bioinformatics 25 (2009) 3158-3165.

[3] L.F. de Figueiredo, T.I. Gossmann, M. Ziegler, S. Schuster: Pathway analysis of NAD⁺ metabolism. Biochem. J. 439 (2011) 341–348.

[4] S. Schuster, J.U. Kreft, N. Brenner, F. Wessely, G. Theißen, E. Ruppin, A. Schroeter: Cooperation and cheating in microbial exoenzyme production - Theoretical analysis for biotechnological applications. Biotechnol. J. 5 (2010) 751-758

[5] T. Pfeiffer, S. Schuster, S. Bonhoeffer: Cooperation and competition in the evolution of ATP-producing pathways. Science 292 (2001) 504-507

[6] S. Schuster, D. Kahn, H.V. Westerhoff: Modular analysis of the control of complex metabolic pathways. Biophys. Chem. 48 (1993) 1-17

[7] S. Schuster: Control analysis in terms of generalized variables characterizing metabolic systems. J. theor. Biol. 182 (1996) 259-268

[8] M. Marhl, M. Perc, S. Schuster: A minimal model for decoding of time-limited Ca²⁺ oscillations. Biophys. Chem. 120 (2006) 161-167

[9] B. Knoke, C. Bodenstein, M. Marhl, M. Perc, S. Schuster: Jensen's Inequality as a tool for explaining the effect of oscillations on the average cytosolic calcium concentration. Theory Biosci. 129 (2010) 25–38

[10] C. Bodenstein, I. Heiland and S. Schuster: Calculating activation energies for temperature compensation in circadian rhythms. Phys. Biol. 8 (2011) 056007

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]