VAV3

Origem: Wikipédia, a enciclopédia livre.
Ir para: navegação, pesquisa
Vav 3 oncogene
Indicadores
Símbolo VAV3
Símbolos alt. FLJ40431
HUGO 12659
Entrez 10451
OMIM 605541
RefSeq NP_001073343
UniProt Q9UKW4
Outros dados
Locus Cr. 1 [1]

Vav 3 oncogene, também conhecido como VAV3, é uma proteína que em humanos é codificado pelo gene VAV3.[1]

Interações[editar | editar código-fonte]

VAV3 mostrou interação com a Grb2.[2][3]

Referências

  1. «Entrez Gene: VAV3 vav 3 oncogene». 
  2. Blagoev, Blagoy; Kratchmarova Irina, Ong Shao-En, Nielsen Mogens, Foster Leonard J, Mann Matthias (2003). «A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling». Nat. Biotechnol. (United States [s.n.]) 21 (3): 315–8. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067.  Parâmetro desconhecido |quotes= ignorado (|titulolivro=) (Ajuda)
  3. Zeng, L; Sachdev P, Yan L, Chan J L, Trenkle T, McClelland M, Welsh J, Wang L H (2000). «Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation». Mol. Cell. Biol. (UNITED STATES [s.n.]) 20 (24): 9212–24. ISSN 0270-7306. PMID 11094073.  Parâmetro desconhecido |quotes= ignorado (|titulolivro=) (Ajuda)

Leitura de apoio[editar | editar código-fonte]

  • Hobert O, Schilling JW, Beckerle MC; et al. (1996). «SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin.». Oncogene [S.l.: s.n.] 12 (7): 1577–81. PMID 8622875. 
  • Tamma SM, Chirmule N, Yagura H; et al. (1997). «CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.». Blood [S.l.: s.n.] 90 (4): 1588–93. PMID 9269777. 
  • Trenkle T, Welsh J, Jung B; et al. (1998). «Non-stoichiometric reduced complexity probes for cDNA arrays.». Nucleic Acids Res. [S.l.: s.n.] 26 (17): 3883–91. doi:10.1093/nar/26.17.3883. PMID 9705494. 
  • Movilla N, Bustelo XR (1999). «Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins.». Mol. Cell. Biol. [S.l.: s.n.] 19 (11): 7870–85. PMID 10523675. 
  • Trenkle T, McClelland M, Adlkofer K, Welsh J (2000). «Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors.». Gene [S.l.: s.n.] 245 (1): 139–49. doi:10.1016/S0378-1119(00)00026-3. PMID 10713454. 
  • Zeng L, Sachdev P, Yan L; et al. (2001). «Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.». Mol. Cell. Biol. [S.l.: s.n.] 20 (24): 9212–24. doi:10.1128/MCB.20.24.9212-9224.2000. PMID 11094073. 
  • Inabe K, Ishiai M, Scharenberg AM; et al. (2002). «Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation.». J. Exp. Med. [S.l.: s.n.] 195 (2): 189–200. doi:10.1084/jem.20011571. PMID 11805146. 
  • Yabana N, Shibuya M (2002). «Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.». Oncogene [S.l.: s.n.] 21 (50): 7720–9. doi:10.1038/sj.onc.1205927. PMID 12400014. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. [S.l.: s.n.] 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Zakaria S, Gomez TS, Savoy DN; et al. (2004). «Differential regulation of TCR-mediated gene transcription by Vav family members.». J. Exp. Med. [S.l.: s.n.] 199 (3): 429–34. doi:10.1084/jem.20031228. PMID 14757747. 
  • Pearce AC, Senis YA, Billadeau DD; et al. (2005). «Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.». J. Biol. Chem. [S.l.: s.n.] 279 (52): 53955–62. doi:10.1074/jbc.M410355200. PMID 15456756. 
  • Charvet C, Canonigo AJ, Billadeau DD, Altman A (2005). «Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.». J. Biol. Chem. [S.l.: s.n.] 280 (15): 15289–99. doi:10.1074/jbc.M500275200. PMID 15708849. 
  • Lyons LS, Burnstein KL (2006). «Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity.». Mol. Endocrinol. [S.l.: s.n.] 20 (5): 1061–72. doi:10.1210/me.2005-0346. PMID 16384856. 
  • Dong Z, Liu Y, Lu S; et al. (2006). «Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer.». Mol. Endocrinol. [S.l.: s.n.] 20 (10): 2315–25. doi:10.1210/me.2006-0048. PMID 16762975. 
Ícone de esboço Este artigo sobre proteínas é um esboço. Você pode ajudar a Wikipédia expandindo-o.