Grb2

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Growth factor receptor-bound protein 2
Indicadores
Símbolo Grb2
Símbolos alt. ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084
Entrez 2885
OMIM 108355
RefSeq NP_002077
UniProt P62993
Outros dados
Locus Cr. 17 [1]

Growth factor receptor-bound protein 2 também conhecido como Grb2 é uma proteína adptadora envolvida na transdução de sinal/sinalização celular. Nos humanos a proteína GRB2 é codificada pelo gene GRB2.[1] [2]

Interações[editar | editar código-fonte]

Grb2 mostrou interação com Arachidonate 5-lipoxygenase,[3] [4] Lymphocyte cytosolic protein 2,[5] [6] [7] [8] [9] GAB2,[10] [11] [12] B-cell linker,[13] [14] [15] [16] Abl gene,[17] [18] CD28,[19] [20] FRS2,[21] [22] [23] [24] Mitogen-activated protein kinase 9,[25] [26] CD22,[27] [28] NEU3,[29] ETV6,[10] MAP2,[30] [31] Dock180,[32] [33] PIK3R1,[34] [35] SH2B1,[36] [37] CRK,[38] [39] [40] GAB1,[5] [41] [42] MST1R,[43] [44] DNM1,[45] [46] Huntingtin,[47] Src,[48] [49] Beta-2 adrenergic receptor,[50] VAV2,[51] [52] ADAM15,[53] RAPGEF1,[54] [55] VAV1,[56] [57] [58] [59] HER2/neu,[52] [60] [61] Epidermal growth factor receptor,[2] [41] [51] [60] [62] [63] [64] [65] [66] [67] PDGFRB,[67] [68] [69] PTK2,[70] [71] [72] [73] [74] Erythropoietin receptor,[75] [76] Linker of activated T cells,[77] [78] [79] Dystroglycan,[80] SH3KBP1,[81] [82] Granulocyte colony-stimulating factor receptor,[83] DCTN1,[84] CDKN1B,[85] Colony stimulating factor 1 receptor,[86] EPH receptor A2,[87] KHDRBS1,[41] [88] [89] RET proto-oncogene,[90] [91] PLCG1,[92] [93] [94] TrkA,[95] [96] PRKAR1A,[64] Janus kinase 2,[97] [98] MUC1,[99] CD117,[76] [100] [101] Fas ligand,[102] [103] Janus kinase 1,[98] [104] VAV3,[51] [105] BCAR1,[71] [106] PTPN1,[107] [108] INPP5D,[109] ITK,[110] [111] SHC1,[49] [51] [112] [113] [114] [115] [116] [117] [118] [119] [120] [121] [122] [123] [124] [125] [126] [127] [128] [129] [130] PTPN12,[131] C-Met,[132] [133] PTPN11,[69] [83] [125] [134] [135] [136] [137] [138] [139] Glycoprotein 130,[59] PTPN6,[49] [134] [140] Syk,[49] [134] MAP4K1,[141] [142] [143] [144] Wiskott-Aldrich syndrome protein,[145] [146] NCKIPSD,[147] [148] PTPRA,[149] [150] [151] BCR gene,[10] [113] [152] [153] [154] [155] CBLB,[156] [157] [158] Cbl gene,[7] [22] [49] [88] [122] [156] [159] [160] [161] [162] [163] [164] [165] SOS1,[6] [22] [40] [41] [46] [49] [51] [58] [66] [88] [93] [99] [113] [120] [122] [129] [166] [167] [168] [169] [170] IRS1,[98] [112] [171] TNK2,[114] [172] MED28,[173] MAP3K1[174] e HNRNPC.[175]

Referências

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Leitura de apoio[editar | editar código-fonte]

  • Colledge M, Froehner SC (1998). «Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction.». Ann. N. Y. Acad. Sci. [S.l.: s.n.] 841: 17–27. doi:10.1111/j.1749-6632.1998.tb10907.x. PMID 9668219. 
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