Grb2

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Growth factor receptor-bound protein 2
Indicadores
Símbolo Grb2
Símbolos alt. ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084
Entrez 2885
OMIM 108355
RefSeq NP_002077
UniProt P62993
Outros dados
Locus Cr. 17 [1]

Growth factor receptor-bound protein 2 também conhecido como Grb2 é uma proteína adptadora envolvida na transdução de sinal/sinalização celular. Nos humanos a proteína GRB2 é codificada pelo gene GRB2.[1][2]

Interações[editar | editar código-fonte]

Grb2 mostrou interação com Arachidonate 5-lipoxygenase,[3][4] Lymphocyte cytosolic protein 2,[5][6][7][8][9] GAB2,[10][11][12] B-cell linker,[13][14][15][16] Abl gene,[17][18] CD28,[19][20] FRS2,[21][22][23][24] Mitogen-activated protein kinase 9,[25][26] CD22,[27][28] NEU3,[29] ETV6,[10] MAP2,[30][31] Dock180,[32][33] PIK3R1,[34][35] SH2B1,[36][37] CRK,[38][39][40] GAB1,[5][41][42] MST1R,[43][44] DNM1,[45][46] Huntingtin,[47] Src,[48][49] Beta-2 adrenergic receptor,[50] VAV2,[51][52] ADAM15,[53] RAPGEF1,[54][55] VAV1,[56][57][58][59] HER2/neu,[52][60][61] Epidermal growth factor receptor,[2][41][51][60][62][63][64][65][66][67] PDGFRB,[67][68][69] PTK2,[70][71][72][73][74] Erythropoietin receptor,[75][76] Linker of activated T cells,[77][78][79] Dystroglycan,[80] SH3KBP1,[81][82] Granulocyte colony-stimulating factor receptor,[83] DCTN1,[84] CDKN1B,[85] Colony stimulating factor 1 receptor,[86] EPH receptor A2,[87] KHDRBS1,[41][88][89] RET proto-oncogene,[90][91] PLCG1,[92][93][94] TrkA,[95][96] PRKAR1A,[64] Janus kinase 2,[97][98] MUC1,[99] CD117,[76][100][101] Fas ligand,[102][103] Janus kinase 1,[98][104] VAV3,[51][105] BCAR1,[71][106] PTPN1,[107][108] INPP5D,[109] ITK,[110][111] SHC1,[49][51][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130] PTPN12,[131] C-Met,[132][133] PTPN11,[69][83][125][134][135][136][137][138][139] Glycoprotein 130,[59] PTPN6,[49][134][140] Syk,[49][134] MAP4K1,[141][142][143][144] Wiskott-Aldrich syndrome protein,[145][146] NCKIPSD,[147][148] PTPRA,[149][150][151] BCR gene,[10][113][152][153][154][155] CBLB,[156][157][158] Cbl gene,[7][22][49][88][122][156][159][160][161][162][163][164][165] SOS1,[6][22][40][41][46][49][51][58][66][88][93][99][113][120][122][129][166][167][168][169][170] IRS1,[98][112][171] TNK2,[114][172] MED28,[173] MAP3K1[174] e HNRNPC.[175]

Referências

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Leitura de apoio[editar | editar código-fonte]

  • Colledge M, Froehner SC (1998). «Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction.». Ann. N. Y. Acad. Sci. 841: 17–27. doi:10.1111/j.1749-6632.1998.tb10907.x. PMID 9668219 
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