Dazoprida

Dazoprida Alerta sobre risco à saúde

Nome IUPAC	4-amino-5-chloro-N-(1,2-diethylpyrazolidin-4-yl)-2-methoxy-benzamide
Identificadores
Número CAS	70181-03-2
PubChem	54801
ChemSpider	49487
Propriedades
Fórmula química	C₁₅H₂₃ClN₄O₂
Massa molar	326.81 g mol^-1
Farmacologia
Via(s) de administração	Oral
Classificação legal	{{{legal_status}}}
Página de dados suplementares
Estrutura e propriedades	n, ε_r, etc.
Dados termodinâmicos	Phase behaviour Solid, liquid, gas
Dados espectrais	UV, IV, RMN, EM
Exceto onde denotado, os dados referem-se a materiais sob condições normais de temperatura e pressão Referências e avisos gerais sobre esta caixa. Alerta sobre risco à saúde.

Dazoprida (AHR-5531) é um fármaco antiemético e gastroprocinético da classe da benzamida o qual nunca foi comercializado.^[1]^[2]^[3]^[4]^[5] Atua como um receptor 5-HT₃ antagonista e agonista do receptor 5-HT₄.^[3]^[4]^[6] Em adição aos seus efeitos gastrointestinais, a dazoprida melhora o aprendizado e a memória em ratos.^[7]

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Referências

↑ Grant SC, Kris MG, Gralla RJ, Clark RA, Tyson LB (1993). «Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy». Cancer Chemotherapy and Pharmacology. 31 (6): 442–4. PMID 8453682
↑ Alphin RS, Proakis AG, Leonard CA; et al. (maio de 1986). «Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility». Digestive Diseases and Sciences. 31 (5): 524–9. PMID 3698769
↑ ^a ^b Costall B, Domeney AM, Gunning SJ; et al. (julho de 1987). «The action of dazopride to enhance gastric emptying and block emesis». Neuropharmacology. 26 (7A): 669–77. PMID 3114664
↑ ^a ^b Costall B, Domeney AM, Naylor RJ, Tattersall FD (setembro de 1987). «Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs». Neuropharmacology. 26 (9): 1321–6. PMID 2890117
↑ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9
↑ Villalón CM, den Boer MO, Heiligers JP, Saxena PR (janeiro de 1991). «Further characterization, by use of tryptamine and benzamide derivatives, of the putative 5-HT4 receptor mediating tachycardia in the pig». British Journal of Pharmacology. 102 (1): 107–12. PMC 1917868. PMID 2043916
↑ Montgomery, S. A.; Halbreich, Uriel (2000). Pharmacotherapy for mood, anxiety, and cognitive disorders. Washington, DC: American Psychiatric Press. ISBN 0-88048-885-9

[pmid8453682-1] Grant SC, Kris MG, Gralla RJ, Clark RA, Tyson LB (1993). «Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy». Cancer Chemotherapy and Pharmacology. 31 (6): 442–4. PMID 8453682

[pmid3698769-2] Alphin RS, Proakis AG, Leonard CA; et al. (maio de 1986). «Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility». Digestive Diseases and Sciences. 31 (5): 524–9. PMID 3698769

[pmid3114664-3] Costall B, Domeney AM, Gunning SJ; et al. (julho de 1987). «The action of dazopride to enhance gastric emptying and block emesis». Neuropharmacology. 26 (7A): 669–77. PMID 3114664

[pmid2890117-4] Costall B, Domeney AM, Naylor RJ, Tattersall FD (setembro de 1987). «Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs». Neuropharmacology. 26 (9): 1321–6. PMID 2890117

[isbn0-412-46630-9-5] David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9

[pmid2043916-6] Villalón CM, den Boer MO, Heiligers JP, Saxena PR (janeiro de 1991). «Further characterization, by use of tryptamine and benzamide derivatives, of the putative 5-HT4 receptor mediating tachycardia in the pig». British Journal of Pharmacology. 102 (1): 107–12. PMC 1917868. PMID 2043916

[isbn0-88048-885-9-7] Montgomery, S. A.; Halbreich, Uriel (2000). Pharmacotherapy for mood, anxiety, and cognitive disorders. Washington, DC: American Psychiatric Press. ISBN 0-88048-885-9

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