DYNLT1
A Cadeia leve de dineína tipo TCTEX1 é uma proteína que em humanos é codificada pelo gene DYNLT1.[2][3][4]
A dineína citoplasmática é o principal complexo de proteína motora responsável por processos móveis baseados em microtúbulos e de extremidade inferior. Cada complexo de dineína consiste em 2 cadeias pesadas que possuem ATPase e atividades motoras, além de um grupo de polipeptídeos acessórios. TCTEX1 é uma cadeia leve de dineína envolvida na ligação de carga (Chuang et al., 2005).[4]
Referências
- ↑ «Human PubMed Reference:»
- ↑ Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (julho de 1996). «Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q». Cytogenet Cell Genet. 73 (1–2): 153–6. PMID 8646886. doi:10.1159/000134329
- ↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (novembro de 2005). «Cytoplasmic dynein nomenclature». J Cell Biol. 171 (3): 411–3. PMC 2171247
. PMID 16260502. doi:10.1083/jcb.200508078
- ↑ a b «Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1»
Leitura adicional[editar | editar código-fonte]
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- King SM, Dillman JF, Benashski SE, et al. (1997). «The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein.». J. Biol. Chem. 271 (50): 32281–7. PMID 8943288. doi:10.1074/jbc.271.50.32281
- Nagano F, Orita S, Sasaki T, et al. (1998). «Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport.». J. Biol. Chem. 273 (46): 30065–8. PMID 9804756. doi:10.1074/jbc.273.46.30065
- Strovel ET, Wu D, Sussman DJ (2000). «Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.». J. Biol. Chem. 275 (4): 2399–403. PMID 10644691. doi:10.1074/jbc.275.4.2399
- Mueller S, Cao X, Welker R, Wimmer E (2002). «Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.». J. Biol. Chem. 277 (10): 7897–904. PMID 11751937. doi:10.1074/jbc.M111937200
- Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). «Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74.». Int. J. Biochem. Cell Biol. 34 (9): 1059–70. PMID 12009301. doi:10.1016/S1357-2725(02)00026-2
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. PMID 12477932. doi:10.1073/pnas.242603899
- Machado RD, Rudarakanchana N, Atkinson C, et al. (2004). «Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.». Hum. Mol. Genet. 12 (24): 3277–86. PMID 14583445. doi:10.1093/hmg/ddg365
- Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). «Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.». J. Biol. Chem. 279 (27): 28522–30. PMID 15117959. doi:10.1074/jbc.M311671200
- Ohka S, Matsuda N, Tohyama K, et al. (2004). «Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome.». J. Virol. 78 (13): 7186–98. PMC 421661
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- Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504
- de Wit NJ, Verschuure P, Kappé G, et al. (2005). «Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1.». Eur. J. Cell Biol. 83 (7): 337–45. PMID 15503857. doi:10.1078/0171-9335-00396
- Chuang JZ, Yeh TY, Bollati F, et al. (2005). «The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.». Dev. Cell. 9 (1): 75–86. PMC 3857739
. PMID 15992542. doi:10.1016/j.devcel.2005.04.003
- Yeh TY, Peretti D, Chuang JZ, et al. (2007). «Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin.». Traffic. 7 (11): 1495–502. PMC 3873093
. PMID 16956385. doi:10.1111/j.1600-0854.2006.00482.x