Módulo:Info/Gene/prova/doc

Uso

Texto da legenda

Info/Gene

Info/Gene/prova

BRCA1 Estruturas disponíveis PDB Pesquisa Human UniProt: PDBe RCSB Lista de códigos id do PDB 1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD, 3PXE, 4IFI, 4IGK, 4JLU, 4OFB, 4U4A, 4Y18, 4Y2G Identificadores Nomes alternativos BRCA1 IDs externos OMIM: 113705 HomoloGene: 5276 GeneCards: BRCA1 Doenças Geneticamente Relacionadas BRCA1 hereditary breast and ovarian cancer syndrome, breast carcinoma, urogenital neoplasm, tumor do ovário, síndrome de cancro hereditário da mama e ovário Ontologia genética Função molecular • tubulin binding • metal ion binding • enzyme binding • zinc ion binding • damaged DNA binding • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • GO:0001105 transcription coactivator activity • androgen receptor binding • RNA binding • ubiquitin protein ligase binding • GO:0050372 ubiquitin-protein transferase activity • DNA binding • transferase activity • RNA polymerase binding • identical protein binding Componente celular • BRCA1-BARD1 complex • condensed nuclear chromosome • BRCA1-A complex • ubiquitin ligase complex • membrana plasmática • cariolinfa • condensed chromosome • citoplasma • cromossoma • núcleo celular • lateral element • GO:0009327 complexo macromolecular • Partículas de ribonucleoproteínas heterogéneas Processo biológico • response to ionizing radiation • centrosome cycle • segregação cromossómica • protein K6-linked ubiquitination • intrinsic apoptotic signaling pathway in response to DNA damage • ciclo celular • double-strand break repair via nonhomologous end joining • GO:0097285 apoptose • regulation of apoptotic process • regulation of gene expression by genetic imprinting • GO:0009373 regulation of transcription, DNA-templated • negative regulation of fatty acid biosynthetic process • transcription, DNA-templated • regulation of transcription by RNA polymerase III • fatty acid biosynthetic process • regulation of DNA methylation • negative regulation of intracellular estrogen receptor signaling pathway • protein autoubiquitination • positive regulation of histone H3-K9 methylation • DNA recombination • positive regulation of angiogenesis • response to estrogen • cellular response to indole-3-methanol • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of protein ubiquitination • androgen receptor signaling pathway • negative regulation of centriole replication • postreplication repair • metabolismo dos lipídios • cellular response to tumor necrosis factor • GO:1900404 positive regulation of DNA repair • fatty acid metabolic process • GO:1901313 positive regulation of gene expression • negative regulation of histone H3-K4 methylation • regulation of cell population proliferation • negative regulation of reactive oxygen species metabolic process • positive regulation of vascular endothelial growth factor production • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of histone H4-K20 methylation • DNA double-strand break processing • double-strand break repair via homologous recombination • negative regulation of histone acetylation • protein ubiquitination • positive regulation of histone H3-K4 methylation • GO:0100026 reparo de ADN • double-strand break repair • positive regulation of histone acetylation • dosage compensation by inactivation of X chromosome • negative regulation of histone H3-K9 methylation • positive regulation of histone H3-K9 acetylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • chordate embryonic development • positive regulation of histone H4-K16 acetylation • cellular response to DNA damage stimulus • protein deubiquitination • replicação do DNA • mitotic G2/M transition checkpoint • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of G0 to G1 transition • transcription by RNA polymerase II • mitotic G2 DNA damage checkpoint signaling • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO Padrão de expressão RNA Mais dados de referência de expressão Ortólogos Espécie Humano Rato Entrez 672 n/a Ensembl ENSG00000012048 n/a UniProt P38398 n/a RefSeq (mRNA) NM_007294 NM_007295 NM_007296 NM_007297 NM_007298 NM_007299 NM_007300 NM_007301 NM_007302 NM_007303 NM_007305 NM_007306 n/a RefSeq (proteína) NP_009225 NP_009228 NP_009229 NP_009230 NP_009231 n/a Localização (UCSC) n/a n/a Pesquisa PubMed n/a Wikidata Ver/Editar Humano

BRCA1 Estruturas disponíveis PDB Pesquisa ortóloga: : PDBe RCSB Lista de códigos id do PDB 1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD, 3PXE, 4IFI, 4IGK, 4JLU, 4OFB, 4U4A, 4Y18, 4Y2G Identificadores Nomes alternativos BRCA1 (HUGO), breast cancer 1, early onset, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, FANCS, breast cancer 1, DNA repair associated, BRCA1 DNA repair associated, Genes IDs externos OMIM: 113705   MGI: 104537   HomoloGene: 5276   GeneCards: BRCA1   OMA: BRCA1 - orthologs Doenças Geneticamente Relacionadas BRCA1 hereditary breast and ovarian cancer syndrome , breast carcinoma , urogenital neoplasm , tumor do ovário , síndrome de cancro hereditário da mama e ovário Localização do gene (Humano) Cromossoma: 17 (humano) Banda 17q21.31 Início 43.044.295 bp Fim 43.170.245 bp Localização do gene (Rato) Cromossoma: 11 (rato) Banda 11 65.18 cM|11 D Início 101.379.590 bp Fim 101.442.781 bp Padrão de expressão de ARN Bgee Humano Rato (ortólogo) Principal expresso em ventricular zone  testículo gónada ganglionic eminence  secondary oocyte  bone marrow cells  sural nerve  trabecular bone  stromal cell of endometrium  epithelium of colon  Principal expresso em secondary oocyte  primary oocyte  zigoto Tubérculo genital tail of embryo  Linha primitiva lumbar spinal ganglion  maxillary prominence  fetal liver hematopoietic progenitor cell  mandibular prominence  Mais dados de expressão de referência BioGPS Mais dados de expressão de referência Ontologia genética Função molecular tubulin binding  metal ion binding  enzyme binding  zinc ion binding  damaged DNA binding  ligação a proteínas plasmáticas  transcription coactivator activity  androgen receptor binding  RNA binding  ubiquitin protein ligase binding  ubiquitin-protein transferase activity  DNA binding  transferase activity  RNA polymerase binding  identical protein binding  Componente celular BRCA1-BARD1 complex  condensed nuclear chromosome  BRCA1-A complex  ubiquitin ligase complex  membrana plasmática  cariolinfa  condensed chromosome  citoplasma  cromossoma  núcleo celular  lateral element  complexo macromolecular  Partículas de ribonucleoproteínas heterogéneas  Processo biológico response to ionizing radiation  centrosome cycle  segregação cromossómica  protein K6-linked ubiquitination  intrinsic apoptotic signaling pathway in response to DNA damage  ciclo celular  double-strand break repair via nonhomologous end joining  apoptose  regulation of apoptotic process  regulation of gene expression by genetic imprinting  regulation of transcription, DNA-templated  negative regulation of fatty acid biosynthetic process  transcription, DNA-templated  regulation of transcription by RNA polymerase III  fatty acid biosynthetic process  regulation of DNA methylation  negative regulation of intracellular estrogen receptor signaling pathway  protein autoubiquitination  positive regulation of histone H3-K9 methylation  DNA recombination  positive regulation of angiogenesis  response to estrogen  cellular response to indole-3-methanol  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of transcription, DNA-templated  positive regulation of protein ubiquitination  androgen receptor signaling pathway  negative regulation of centriole replication  postreplication repair  metabolismo dos lipídios  cellular response to tumor necrosis factor  positive regulation of DNA repair  fatty acid metabolic process  positive regulation of gene expression  negative regulation of histone H3-K4 methylation  regulation of cell population proliferation  negative regulation of reactive oxygen species metabolic process  positive regulation of vascular endothelial growth factor production  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  positive regulation of transcription by RNA polymerase II  positive regulation of histone H4-K20 methylation  DNA double-strand break processing  double-strand break repair via homologous recombination  negative regulation of histone acetylation  protein ubiquitination  positive regulation of histone H3-K4 methylation  reparo de ADN  double-strand break repair  positive regulation of histone acetylation  dosage compensation by inactivation of X chromosome  negative regulation of histone H3-K9 methylation  positive regulation of histone H3-K9 acetylation  positive regulation of transcription, DNA-templated  chordate embryonic development  positive regulation of histone H4-K16 acetylation  cellular response to DNA damage stimulus  protein deubiquitination  replicação do DNA  mitotic G2/M transition checkpoint  regulation of transcription by RNA polymerase II  negative regulation of G0 to G1 transition  transcription by RNA polymerase II  mitotic G2 DNA damage checkpoint signaling  regulation of signal transduction by p53 class mediator  Fontes: Amigo / QuickGO Ortólogos Espécie Humano Rato Entrez 672 12189 Ensembl ENSG00000012048 ENSMUSG00000017146 UniProt P38398 P48754 RefSeq (ARNm) NM_007294 NM_007295 NM_007296 NM_007297 NM_007298 NM_007299 NM_007300 NM_007301 NM_007302 NM_007303 NM_007305 NM_007306 NM_009764 RefSeq (proteína) NP_009225 NP_009228 NP_009229 NP_009230 NP_009231 NP_033894 Localização (UCSC) Chr 17: 43.04 – 43.17 Mb Chr 11: 101.38 – 101.44 Mb Pesquise PubMed Wikidata Ver/Editar gene humano Ver/Editar gene do rato