Caspase 3

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Caspase 3

A caspase 3 é um das caspases existentes. Interage com a caspase 8.

O gene correspondente codifica uma proteína que é membro da família das proteases de cisteína-aspartato. A activação sequêncial das caspases desempenha um papel central na fase de execução da apoptose celular. As caspases existem como pró-enzimas inactivas que depois sofrem um processamento proteolítico em resíduos de aspartato, para produzirem duas subunidades, uma pequena e outra grande, que dimerizam para formar a enzima activa. Esta enzima faz a clivagem e a activação da caspase 6, caspase 7 e caspase 9. A própria proteína é processada pela caspase 8, caspase 9 e caspase 10. É a caspase predominante envolvida na clivagem da proteína percursora amilóide-beta 4A, que está associada à morte neuronal na doença de Alzheimer. O splicing alternativo deste gene resulta em dois transcritos que codificam a mesma proteína.[1]

A Caspase 3 mostrou interação com:

Referências[editar | editar código-fonte]

  1. Entrez Gene: CASP3 caspase 3, apoptosis-related cysteine peptidase.
  2. Guo, Yin; Srinivasula Srinivasa M, Druilhe Anne, Fernandes-Alnemri Teresa, Alnemri Emad S. (Apr. 2002). "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria". J. Biol. Chem. 277 (16): 13430–7. DOI:10.1074/jbc.M108029200. ISSN 0021-9258. PMID 11832478.
  3. Srinivasula, S M; Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri E S. (Dec. 1996). "Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases". Proc. Natl. Acad. Sci. U.S.A. 93 (25): 14486–91. DOI:10.1073/pnas.93.25.14486. ISSN 0027-8424. PMID 8962078.
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  7. Samali, A; Cai J, Zhivotovsky B, Jones D P, Orrenius S. (Apr. 1999). "Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells". EMBO J. 18 (8): 2040–8. DOI:10.1093/emboj/18.8.2040. ISSN 0261-4189. PMID 10205158.
  8. Xanthoudakis, S; Roy S, Rasper D, Hennessey T, Aubin Y, Cassady R, Tawa P, Ruel R, Rosen A, Nicholson D W. (Apr. 1999). "Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis". EMBO J. 18 (8): 2049–56. DOI:10.1093/emboj/18.8.2049. ISSN 0261-4189. PMID 10205159.
  9. Ruzzene, Maria; Penzo Daniele, Pinna Lorenzo A. (May. 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. 364 (Pt 1): 41–7. ISSN 0264-6021. PMID 11988074.
  10. Chen, Y R; Kori R, John B, Tan T H. (Nov. 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. 288 (4): 981–9. DOI:10.1006/bbrc.2001.5862. ISSN 0006-291X. PMID 11689006.
  11. Tamm, I; Wang Y, Sausville E, Scudiero D A, Vigna N, Oltersdorf T, Reed J C. (Dec. 1998). "IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs". Cancer Res. 58 (23): 5315–20. ISSN 0008-5472. PMID 9850056.
  12. Shin, S; Sung B J, Cho Y S, Kim H J, Ha N C, Hwang J I, Chung C W, Jung Y K, Oh B H. (Jan. 2001). "An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7". Biochemistry 40 (4): 1117–23. DOI:10.1021/bi001603q. ISSN 0006-2960. PMID 11170436.
  13. Lee, Z H; Lee S E, Kwack K, Yeo W, Lee T H, Bae S S, Suh P G, Kim H H. (Mar. 2001). "Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells". J. Leukoc. Biol. 69 (3): 490–6. ISSN 0741-5400. PMID 11261798.
  14. Leo, E; Deveraux Q L, Buchholtz C, Welsh K, Matsuzawa S, Stennicke H R, Salvesen G S, Reed J C. (Mar. 2001). "TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis". J. Biol. Chem. 276 (11): 8087–93. DOI:10.1074/jbc.M009450200. ISSN 0021-9258. PMID 11098060.
  15. Suzuki, Y; Nakabayashi Y, Takahashi R. (Jul. 2001). "Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death". Proc. Natl. Acad. Sci. U.S.A. 98 (15): 8662–7. DOI:10.1073/pnas.161506698. ISSN 0027-8424. PMID 11447297.
  16. Silke, John; Hawkins Christine J, Ekert Paul G, Chew Joanne, Day Catherine L, Pakusch Miha, Verhagen Anne M, Vaux David L. (Apr. 2002). "The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites". J. Cell Biol. 157 (1): 115–24. DOI:10.1083/jcb.200108085. ISSN 0021-9525. PMID 11927604.
  17. Riedl, S J; Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik S W, Liddington R C, Salvesen G S. (Mar. 2001). "Structural basis for the inhibition of caspase-3 by XIAP". Cell 104 (5): 791–800. DOI:10.1016/S0092-8674(01)00274-4. ISSN 0092-8674. PMID 11257232.
  18. Roy, N; Deveraux Q L, Takahashi R, Salvesen G S, Reed J C. (Dec. 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. DOI:10.1093/emboj/16.23.6914. ISSN 0261-4189. PMID 9384571.
  19. Deveraux, Q L; Takahashi R, Salvesen G S, Reed J C. (Jul. 1997). "X-linked IAP is a direct inhibitor of cell-death proteases". Nature 388 (6639): 300–4. DOI:10.1038/40901. ISSN 0028-0836. PMID 9230442.
  20. Suzuki, Y; Nakabayashi Y, Nakata K, Reed J C, Takahashi R. (Jul. 2001). "X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes". J. Biol. Chem. 276 (29): 27058–63. DOI:10.1074/jbc.M102415200. ISSN 0021-9258. PMID 11359776.

Leitura de apoio[editar | editar código-fonte]

  • Cohen GM. (1997). "Caspases: the executioners of apoptosis.". Biochem. J. 326 ( Pt 1): 1–16. PMID 9337844.
  • Roig J, Traugh JA. (2001). "Cytostatic p21 G protein-activated protein kinase gamma-PAK.". Vitam. Horm. 62: 167–98. DOI:10.1016/S0083-6729(01)62004-1. PMID 11345898.
  • Zhao LJ, Zhu H. (2005). "Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design.". Curr. Drug Targets Immune Endocr. Metabol. Disord. 4 (4): 265–75. DOI:10.2174/1568008043339668. PMID 15578977.
  • Le Rouzic E, Benichou S. (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle.". Retrovirology 2: 11. DOI:10.1186/1742-4690-2-11. PMID 15725353.
  • Sykes MC, Mowbray AL, Jo H. (2007). "Reversible glutathiolation of caspase-3 by glutaredoxin as a novel redox signaling mechanism in tumor necrosis factor-alpha-induced cell death.". Circ. Res. 100 (2): 152–4. DOI:10.1161/01.RES.0000258171.08020.72. PMID 17272816.
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