Substrato receptor 3 do fator de crescimento de fibroblastos é uma proteína que em humanos é codificada pelo geneFRS3.[2][3][4]
A proteína codificada por esse gene é um substrato para o receptor do fator de crescimento de fibroblastos. É encontrado na membrana plasmática periférica e funciona na ligação da estimulação do receptor FGF aos ativadores de Ras.[4]
↑Wang JK, Xu H, Li HC, Goldfarb M (outubro de 1996). «Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras». Oncogene. 13 (4): 721–9. PMID8761293
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Lim YP, Low BC, Lim J, et al. (1999). «Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling.». J. Biol. Chem. 274 (27): 19025–34. PMID10383403. doi:10.1074/jbc.274.27.19025
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Yan KS, Kuti M, Yan S, et al. (2002). «FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.». J. Biol. Chem. 277 (19): 17088–94. PMID11877385. doi:10.1074/jbc.M107963200
Ranzi V, Meakin SO, Miranda C, et al. (2003). «The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.». Endocrinology. 144 (3): 922–8. PMID12586769. doi:10.1210/en.2002-221002
Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6.». Nature. 425 (6960): 805–11. PMID14574404. doi:10.1038/nature02055
Gotoh N, Laks S, Nakashima M, et al. (2004). «FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.». FEBS Lett. 564 (1-2): 14–8. PMID15094036. doi:10.1016/S0014-5793(04)00287-X
Hassel S, Eichner A, Yakymovych M, et al. (2004). «Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.». Proteomics. 4 (5): 1346–58. PMID15188402. doi:10.1002/pmic.200300770
Huang L, Gotoh N, Zhang S, et al. (2004). «SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.». Biochem. Biophys. Res. Commun. 324 (3): 1011–7. PMID15485655. doi:10.1016/j.bbrc.2004.09.152
Harada A, Katoh H, Negishi M (2005). «Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells.». J. Biol. Chem. 280 (18): 18418–24. PMID15738000. doi:10.1074/jbc.M411356200
Huang L, Watanabe M, Chikamori M, et al. (2006). «Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.». Oncogene. 25 (49): 6457–66. PMID16702953. doi:10.1038/sj.onc.1209656
. PMID 10629055. doi:10.1128/MCB.20.3.979-989.2000
