SRY

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SRY é o gene determinante sexual do cromossomo Y nos mamíferos térios (marsupiais e placentários).[1]

Referências

  1. Wallis MC, Waters PD, Graves JA. (June 2008). "Sex determination in mammals - Before and after the evolution of SRY". Cell. Mol. Life Sci. 65 (20): 3182. DOI:10.1007/s00018-008-8109-z. PMID 18581056.

Leitura de apoio[editar | editar código-fonte]

  • Haqq CM, King CY, Ukiyama E, et al.. (1995). "Molecular basis of mammalian sexual determination: activation of Müllerian inhibiting substance gene expression by SRY.". Science 266 (5190): 1494–500. DOI:10.1126/science.7985018. PMID 7985018.
  • Goodfellow PN, Lovell-Badge R. (1994). "SRY and sex determination in mammals.". Annu. Rev. Genet. 27: 71–92. DOI:10.1146/annurev.ge.27.120193.000443. PMID 8122913.
  • Hawkins JR. (1994). "Mutational analysis of SRY in XY females.". Hum. Mutat. 2 (5): 347–50. DOI:10.1002/humu.1380020504. PMID 8257986.
  • Harley VR. (2002). "The molecular action of testis-determining factors SRY and SOX9.". Novartis Found. Symp. 244: 57–66; discussion 66–7, 79–85, 253–7. DOI:10.1002/0470868732.ch6. PMID 11990798.
  • Jordan BK, Vilain E. (2003). "Sry and the genetics of sex determination.". Adv. Exp. Med. Biol. 511: 1–13; discussion 13–4. PMID 12575752.
  • Oh HJ, Lau YF. (2006). "KRAB: a partner for SRY action on chromatin.". Mol. Cell. Endocrinol. 247 (1-2): 47–52. DOI:10.1016/j.mce.2005.12.011. PMID 16414182.
  • Polanco JC, Koopman P. (2007). "Sry and the hesitant beginnings of male development.". Dev. Biol. 302 (1): 13–24. DOI:10.1016/j.ydbio.2006.08.049. PMID 16996051.
  • Hawkins JR, Taylor A, Berta P, et al.. (1992). "Mutational analysis of SRY: nonsense and missense mutations in XY sex reversal.". Hum. Genet. 88 (4): 471–4. DOI:10.1007/BF00215684. PMID 1339396.
  • Hawkins JR, Taylor A, Goodfellow PN, et al.. (1992). "Evidence for increased prevalence of SRY mutations in XY females with complete rather than partial gonadal dysgenesis.". Am. J. Hum. Genet. 51 (5): 979–84. PMID 1415266.
  • Ferrari S, Harley VR, Pontiggia A, et al.. (1992). "SRY, like HMG1, recognizes sharp angles in DNA.". EMBO J. 11 (12): 4497–506. PMID 1425584.
  • Jäger RJ, Harley VR, Pfeiffer RA, et al.. (1993). "A familial mutation in the testis-determining gene SRY shared by both sexes.". Hum. Genet. 90 (4): 350–5. PMID 1483689.
  • Vilain E, McElreavey K, Jaubert F, et al.. (1992). "Familial case with sequence variant in the testis-determining region associated with two sex phenotypes.". Am. J. Hum. Genet. 50 (5): 1008–11. PMID 1570829.
  • Müller J, Schwartz M, Skakkebaek NE. (1992). "Analysis of the sex-determining region of the Y chromosome (SRY) in sex reversed patients: point-mutation in SRY causing sex-reversion in a 46,XY female.". J. Clin. Endocrinol. Metab. 75 (1): 331–3. DOI:10.1210/jc.75.1.331. PMID 1619028.
  • McElreavey KD, Vilain E, Boucekkine C, et al.. (1992). "XY sex reversal associated with a nonsense mutation in SRY.". Genomics 13 (3): 838–40. DOI:10.1016/0888-7543(92)90164-N. PMID 1639410.
  • Sinclair AH, Berta P, Palmer MS, et al.. (1990). "A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif.". Nature 346 (6281): 240–4. DOI:10.1038/346240a0. PMID 1695712.
  • Berkovitz GD, Fechner PY, Zacur HW, et al.. (1991). "Clinical and pathologic spectrum of 46,XY gonadal dysgenesis: its relevance to the understanding of sex differentiation.". Medicine (Baltimore) 70 (6): 375–83. PMID 1956279.
  • Berta P, Hawkins JR, Sinclair AH, et al.. (1991). "Genetic evidence equating SRY and the testis-determining factor.". Nature 348 (6300): 448–50. DOI:10.1038/348448A0. PMID 2247149.
  • Jäger RJ, Anvret M, Hall K, Scherer G. (1991). "A human XY female with a frame shift mutation in the candidate testis-determining gene SRY.". Nature 348 (6300): 452–4. DOI:10.1038/348452a0. PMID 2247151.
  • Ellis NA, Goodfellow PJ, Pym B, et al.. (1989). "The pseudoautosomal boundary in man is defined by an Alu repeat sequence inserted on the Y chromosome.". Nature 337 (6202): 81–4. DOI:10.1038/337081a0. PMID 2909893.
  • Whitfield LS, Hawkins TL, Goodfellow PN, Sulston J. (1995). "41 kilobases of analyzed sequence from the pseudoautosomal and sex-determining regions of the short arm of the human Y chromosome.". Genomics 27 (2): 306–11. DOI:10.1006/geno.1995.1047. PMID 7557997.
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