Receptor metabotrópico de glutamato 4

Origem: Wikipédia, a enciclopédia livre.
Ir para: navegação, pesquisa

O Receptor metabotrópico de glutamato 4 é uma proteína que em seres humanos é codificada pelo gene GRM4.[1] [2] [3] [4] Os receptores metabotrópicos de glutamato são uma família de receptores acoplados à proteína G.

Referências

  1. Chad J. Swanson, Mark Bures, Michael P. Johnson, Anni-Maija Linden, James A. Monn & Darryle D. Schoepp. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders (em inglês) fevereiro de 2005. Visitado em 1 de julho de 2010.
  2. Makoff A, Lelchuk R, Oxer M, Harrington K, Emson P. (Dec 1996). "Molecular characterization and localization of human metabotropic glutamate receptor type 4". Brain Res Mol Brain Res 37 (1-2): 239–48. PMID 8738157.
  3. Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR Jr, Johnson BG, Schoepp DD, Belagaje RM. (Apr 1998). "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells". Brain Res Mol Brain Res 53 (1-2): 88–97. PMID 9473604.
  4. Entrez Gene: GRM4 glutamate receptor, metabotropic 4.

Leitura de apoio[editar | editar código-fonte]

  • Flor PJ, Lukic S, Rüegg D, et al.. (1995). "Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4.". Neuropharmacology 34 (2): 149–55. DOI:10.1016/0028-3908(94)00149-M. PMID 7617140.
  • Scherer SW, Duvoisin RM, Kuhn R, et al.. (1997). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.". Genomics 31 (2): 230–3. DOI:10.1006/geno.1996.0036. PMID 8824806.
  • Gomeza J, Mary S, Brabet I, et al.. (1996). "Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.". Mol. Pharmacol. 50 (4): 923–30. PMID 8863838.
  • Fu M, Wang C, Reutens AT, et al.. (2000). "p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation.". J. Biol. Chem. 275 (27): 20853–60. DOI:10.1074/jbc.M000660200. PMID 10779504.
  • Barbon A, Ferraboli S, Barlati S. (2000). "Assignment of the human metabotropic glutamate receptor gene GRM4 to chromosome 6 band p21.3 by radiation hybrid mapping.". Cytogenet. Cell Genet. 88 (3-4): 210. DOI:10.1159/000015551. PMID 10828590.
  • Ohtsuki T, Toru M, Arinami T. (2002). "Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia.". Psychiatr. Genet. 11 (2): 79–83. DOI:10.1097/00041444-200106000-00004. PMID 11525421.
  • Erdemir T, Bilican B, Oncel D, et al.. (2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX).". J. Cell. Sci. 115 (Pt 1): 207–16. PMID 11801738.
  • Collard CD, Park KA, Montalto MC, et al.. (2002). "Neutrophil-derived glutamate regulates vascular endothelial barrier function.". J. Biol. Chem. 277 (17): 14801–11. DOI:10.1074/jbc.M110557200. PMID 11847215.
  • Enz R. (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.". FEBS Lett. 514 (2-3): 184–8. DOI:10.1016/S0014-5793(02)02361-X. PMID 11943148.
  • Gaughan L, Logan IR, Cook S, et al.. (2002). "Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.". J. Biol. Chem. 277 (29): 25904–13. DOI:10.1074/jbc.M203423200. PMID 11994312.
  • Mungall AJ, Palmer SA, Sims SK, et al.. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al.. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
  • Iacovelli L, Capobianco L, Iula M, et al.. (2004). "Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2).". Mol. Pharmacol. 65 (5): 1103–10. DOI:10.1124/mol.65.5.1103. PMID 15102938.
  • Hermit MB, Greenwood JR, Bräuner-Osborne H. (2004). "Mutation-induced quisqualic acid and ibotenic acid affinity at the metabotropic glutamate receptor subtype 4: ligand selectivity results from a synergy of several amino acid residues.". J. Biol. Chem. 279 (33): 34811–7. DOI:10.1074/jbc.M404109200. PMID 15184361.
  • Yoo BC, Jeon E, Hong SH, et al.. (2005). "Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line.". Clin. Cancer Res. 10 (12 Pt 1): 4176–84. DOI:10.1158/1078-0432.CCR-1114-03. PMID 15217955.
  • Chang HJ, Yoo BC, Lim SB, et al.. (2005). "Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance.". Clin. Cancer Res. 11 (9): 3288–95. DOI:10.1158/1078-0432.CCR-04-1912. PMID 15867225.
  • Mathiesen JM, Ramirez MT. (2006). "The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation.". Br. J. Pharmacol. 148 (3): 279–90. DOI:10.1038/sj.bjp.0706733. PMID 16582932.
  • Iacovelli L, Arcella A, Battaglia G, et al.. (2006). "Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.". J. Neurosci. 26 (32): 8388–97. DOI:10.1523/JNEUROSCI.2285-06.2006. PMID 16899734.
Ícone de esboço Este artigo sobre Biologia molecular é um esboço. Você pode ajudar a Wikipédia expandindo-o.