Receptor D₄ de dopamina

DRD4
Identificadores
Nomes alternativos	DRD4
IDs externos	OMIM: 126452 HomoloGene: 20215 GeneCards: DRD4
Targeted by Drug
	PF-592379, Rotigotina, A-412997, ABT-670, dopamina, fenoldopam, quinpirole, WAY-100635, apomorfina, cabergolina, lisurida, pergolide, roxindole, bromocriptina, (+)-butaclamol, clorpromazina, clozapina, eticlopride, haloperidol, L745870, loxapina, 5-chloro-2-methoxy-4-(methylamino)-N-(2-methyl-1-(phenylmethyl)-3-pyrrolidinyl)benzamide, perospirone, piribedil, prochlorperazine, sertindole, sonepiprazole, espiperona, levosulpiride, Tergurida, trifluoperazina, zotepina, pimozida, droperidol, haloperidol, apomorfina, thioridazine hydrochloride, bromocriptine mesylate, chlorpromazine hydrochloride, pergolide mesylate, promazine hydrochloride
Ontologia genética
Função molecular	• signal transducer activity; • potassium channel regulator activity; • SH3 domain binding; • identical protein binding; • dopamine neurotransmitter receptor activity; • G protein-coupled receptor activity; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • dopamine binding; • dopamine neurotransmitter receptor activity, coupled via Gi/Go; • epinephrine binding; • norepinephrine binding; • metal ion binding; • G protein-coupled serotonin receptor activity; • neurotransmitter receptor activity;
Componente celular	• integral component of membrane; • integral component of plasma membrane; • membrane; • membrana plasmática; • postsynapse; • glutamatergic synapse; • dendrito;
Processo biológico	• response to amphetamine; • rhythmic process; • arachidonic acid secretion; • regulation of circadian rhythm; • positive regulation of dopamine uptake involved in synaptic transmission; • GO:0072468 transdução de sinal; • fear response; • dopamine metabolic process; • behavioral response to ethanol; • behavioral response to cocaine; • positive regulation of sodium:proton antiporter activity; • cellular calcium ion homeostasis; • positive regulation of kinase activity; • adult locomotory behavior; • potencial pós-sináptico inibitório; • negative regulation of protein secretion; • comportamento social; • negative regulation of voltage-gated calcium channel activity; • regulation of dopamine metabolic process; • response to histamine; • behavioral fear response; • dopamine receptor signaling pathway; • G protein-coupled receptor signaling pathway; • adenylate cyclase-inhibiting dopamine receptor signaling pathway; • regulation of postsynaptic neurotransmitter receptor internalization; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • chemical synaptic transmission; • G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	1815
	n/a
	ENSG00000069696; ENSG00000276825
	n/a
	P21917
	n/a
	NM_000797
	n/a
	NP_000788
	n/a
	Wikidata
Ver/Editar Humano

O receptor D₄ de dopamina é um receptor acoplado à proteína G, codificado pelo gene DRD4.^[3] Tal como outros tipos de receptores de dopamina, o receptor D₄ é activado pelo neurotransmissor dopamina. É também um alvo para drogas que tratam a esquizofrenia e a doença de Parkinson.

O receptor D₄ é considerado um Receptor D2 de dopamina, no qual o receptor activado inibe a enzima adenilato ciclase, reduzindo assim a concentração intracelular do mensageiro secundário AMP cíclico.^[4]

Referências

↑ «Drogas que interagem fisicamente com Dopamine receptor D4 ver/editar referências no wikidata»
↑ «Human PubMed Reference:»
↑ Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O (1991). «Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine». Nature. 350 (6319): 610–4. PMID 1840645. doi:10.1038/350610a0
↑ Neve KA, Seamans JK, Trantham-Davidson H (2004). «Dopamine receptor signaling». J. Recept. Signal Transduct. Res. 24 (3): 165–205. PMID 15521361

Este artigo sobre Biologia molecular é um esboço. Você pode ajudar a Wikipédia expandindo-o.

[1] «Drogas que interagem fisicamente com Dopamine receptor D4 ver/editar referências no wikidata»

[2] «Human PubMed Reference:»

[pmid1840645-3] Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O (1991). «Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine». Nature. 350 (6319): 610–4. PMID 1840645. doi:10.1038/350610a0

[pmid15521361-4] Neve KA, Seamans JK, Trantham-Davidson H (2004). «Dopamine receptor signaling». J. Recept. Signal Transduct. Res. 24 (3): 165–205. PMID 15521361

[1]

[2]

[3]

[4]