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Receptor metabotrópico de glutamato 4

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Glutamate metabotropic receptor 4
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O receptor metabotrópico de glutamato 4 é uma proteína que em seres humanos é codificada pelo gene GRM4.[1][2][3][4] Os receptores metabotrópicos de glutamato são uma família de receptores acoplados à proteína G.

Referências

  1. ↑ Chad J. Swanson, Mark Bures, Michael P. Johnson, Anni-Maija Linden, James A. Monn & Darryle D. Schoepp. «Metabotropic glutamate receptors as novel targets for anxiety and stress disorders» (em inglês). fevereiro de 2005. Consultado em 1 de julho de 2010 
  2. ↑ Makoff A, Lelchuk R, Oxer M, Harrington K, Emson P (1996). «Molecular characterization and localization of human metabotropic glutamate receptor type 4». Brain Res Mol Brain Res. 37 (1-2): 239–48. PMID 8738157 
  3. ↑ Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR Jr, Johnson BG, Schoepp DD, Belagaje RM (1998). «Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells». Brain Res Mol Brain Res. 53 (1-2): 88–97. PMID 9473604 
  4. ↑ «Entrez Gene: GRM4 glutamate receptor, metabotropic 4» 

Bibliografia

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  • Flor PJ, Lukic S, Rüegg D; et al. (1995). «Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4.». Neuropharmacology. 34 (2): 149–55. PMID 7617140. doi:10.1016/0028-3908(94)00149-M 
  • Scherer SW, Duvoisin RM, Kuhn R; et al. (1997). «Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.». Genomics. 31 (2): 230–3. PMID 8824806. doi:10.1006/geno.1996.0036 
  • Gomeza J, Mary S, Brabet I; et al. (1996). «Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.». Mol. Pharmacol. 50 (4): 923–30. PMID 8863838 
  • Fu M, Wang C, Reutens AT; et al. (2000). «p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation.». J. Biol. Chem. 275 (27): 20853–60. PMID 10779504. doi:10.1074/jbc.M000660200 
  • Barbon A, Ferraboli S, Barlati S (2000). «Assignment of the human metabotropic glutamate receptor gene GRM4 to chromosome 6 band p21.3 by radiation hybrid mapping.». Cytogenet. Cell Genet. 88 (3-4). 210 páginas. PMID 10828590. doi:10.1159/000015551 
  • Ohtsuki T, Toru M, Arinami T (2002). «Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia.». Psychiatr. Genet. 11 (2): 79–83. PMID 11525421. doi:10.1097/00041444-200106000-00004 
  • Erdemir T, Bilican B, Oncel D; et al. (2002). «DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX).». J. Cell. Sci. 115 (Pt 1): 207–16. PMID 11801738 
  • Collard CD, Park KA, Montalto MC; et al. (2002). «Neutrophil-derived glutamate regulates vascular endothelial barrier function.». J. Biol. Chem. 277 (17): 14801–11. PMID 11847215. doi:10.1074/jbc.M110557200 
  • Enz R (2002). «The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.». FEBS Lett. 514 (2-3): 184–8. PMID 11943148. doi:10.1016/S0014-5793(02)02361-X 
  • Gaughan L, Logan IR, Cook S; et al. (2002). «Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.». J. Biol. Chem. 277 (29): 25904–13. PMID 11994312. doi:10.1074/jbc.M203423200 
  • Mungall AJ, Palmer SA, Sims SK; et al. (2003). «The DNA sequence and analysis of human chromosome 6.». Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285 
  • Iacovelli L, Capobianco L, Iula M; et al. (2004). «Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2).». Mol. Pharmacol. 65 (5): 1103–10. PMID 15102938. doi:10.1124/mol.65.5.1103 
  • Hermit MB, Greenwood JR, Bräuner-Osborne H (2004). «Mutation-induced quisqualic acid and ibotenic acid affinity at the metabotropic glutamate receptor subtype 4: ligand selectivity results from a synergy of several amino acid residues.». J. Biol. Chem. 279 (33): 34811–7. PMID 15184361. doi:10.1074/jbc.M404109200 
  • Yoo BC, Jeon E, Hong SH; et al. (2005). «Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line.». Clin. Cancer Res. 10 (12 Pt 1): 4176–84. PMID 15217955. doi:10.1158/1078-0432.CCR-1114-03 
  • Chang HJ, Yoo BC, Lim SB; et al. (2005). «Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance.». Clin. Cancer Res. 11 (9): 3288–95. PMID 15867225. doi:10.1158/1078-0432.CCR-04-1912 
  • Mathiesen JM, Ramirez MT (2006). «The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation.». Br. J. Pharmacol. 148 (3): 279–90. PMC 1751557Acessível livremente. PMID 16582932. doi:10.1038/sj.bjp.0706733 
  • Iacovelli L, Arcella A, Battaglia G; et al. (2006). «Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.». J. Neurosci. 26 (32): 8388–97. PMID 16899734. doi:10.1523/JNEUROSCI.2285-06.2006 


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