Predefinição:Primeira fase da Copa Sul-Americana de 2021
| Chave | Equipe 1
|
Total | Equipe 2 | Ida | Volta |
|---|---|---|---|---|---|
| BOL1 | Guabirá 
|
6–2 | Nacional Potosí
|
4–1 | 2–1 |
| BOL2 | Jorge Wilstermann
|
4–2 | Atlético Palmaflor
|
2–1 | 2–1 |
| CHI1 | Antofagasta 
|
0–4 | Huachipato
|
0–1 | 0–3 |
| CHI2 | Cobresal
|
1–2 | Palestino
|
0–0 | 1–2 |
| COL1 | Deportes Tolima 
|
3–0 | Deportivo Cali
|
3–0 | 0–0 |
| COL2 | La Equidad
|
3–2 | Deportivo Pasto
|
1–2 | 2–0 |
| ECU1 | Macará 
|
2–4 | Emelec
|
2–2 | 0–2 |
| ECU2 | Aucas
|
5–1 | Guayaquil City
|
2–1 | 3–0 |
| PAR1 | 12 de Octubre 
|
0–0 (5–4 p) | Nacional
|
0–0 | 0–0 |
| PAR2 | Guaireña
|
3–6 | River Plate-PAR
|
1–2 | 2–4 |
| PER1 | UTC 
|
0–5 | Sport Huancayo
|
0–1 | 0–4 |
| PER2 | Carlos A. Mannucci
|
3–5 | Melgar
|
1–2 | 2–3 |
| URU1 | Montevideo City Torque 
|
2–0 | Fénix
|
0–0 | 2–0 |
| URU2 | Cerro Largo
|
3–6 | Peñarol
|
2–2 | 1–4 |
| VEN1 | Metropolitanos 
|
3–0 | Academia Puerto Cabello
|
2–0 | 1–0 |
| VEN2 | Aragua
|
2–2 (gf) | Mineros de Guayana
|
0–1 | 2–1 |