Receptor metabotrópico de glutamato 2

Glutamate metabotropic receptor 2
Identificadores
Nomes alternativos
IDs externos	GeneCards: [1]
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
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	Wikidata
Ver/Editar Humano

O receptor metabotrópico de glutamato 2 (mGlu2) é uma proteína que em seres humanos é codificada pelo gene GRM2.^[1]^[2]^[3] Os receptores metabotrópicos de glutamato são uma família de receptores acoplados à proteína G.

Referências

↑ Chad J. Swanson, Mark Bures, Michael P. Johnson, Anni-Maija Linden, James A. Monn & Darryle D. Schoepp. «Metabotropic glutamate receptors as novel targets for anxiety and stress disorders» (em inglês). fevereiro de 2005. Consultado em 1 de julho de 2010
↑ Flor PJ, Lindauer K, Puttner I, Ruegg D, Lukic S, Knopfel T, Kuhn R (1995). «Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2». Eur J Neurosci. 7 (4): 622–9. PMID 7620613. doi:10.1111/j.1460-9568.1995.tb00666.x
↑ «Entrez Gene: GRM2 glutamate receptor, metabotropic 2»

Bibliografia

Scherer SW, Duvoisin RM, Kuhn R; et al. (1997). «Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.». Genomics. 31 (2): 230–3. PMID 8824806. doi:10.1006/geno.1996.0036
Gomeza J, Mary S, Brabet I; et al. (1996). «Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.». Mol. Pharmacol. 50 (4): 923–30. PMID 8863838
Snow BE, Hall RA, Krumins AM; et al. (1998). «GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.». J. Biol. Chem. 273 (28): 17749–55. PMID 9651375. doi:10.1074/jbc.273.28.17749
Malherbe P, Knoflach F, Broger C; et al. (2001). «Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor.». Mol. Pharmacol. 60 (5): 944–54. PMID 11641422
Martí SB, Cichon S, Propping P, Nöthen M (2002). «Human metabotropic glutamate receptor 2 gene (GRM2): chromosomal sublocalization (3p21.1-p21.2) and genomic organization.». Am. J. Med. Genet. 114 (1): 12–4. PMID 11840499. doi:10.1002/ajmg.1622
Krampfl K, Schlesinger F, Zörner A; et al. (2002). «Control of kinetic properties of GluR2 flop AMPA-type channels: impact of R/G nuclear editing.». Eur. J. Neurosci. 15 (1): 51–62. PMID 11860506. doi:10.1046/j.0953-816x.2001.01841.x
Dietrich D, Kral T, Clusmann H; et al. (2002). «Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus.». Neuropharmacology. 42 (3): 297–305. PMID 11897108. doi:10.1016/S0028-3908(01)00193-9
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Kuwabara T, Hsieh J, Nakashima K; et al. (2004). «A small modulatory dsRNA specifies the fate of adult neural stem cells.». Cell. 116 (6): 779–93. PMID 15035981. doi:10.1016/S0092-8674(04)00248-X
Tang FR, Chia SC, Chen PM; et al. (2004). «Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.». Epilepsy Res. 59 (2-3): 167–80. PMID 15246118. doi:10.1016/j.eplepsyres.2004.04.002
Anneser JM, Chahli C, Ince PG; et al. (2004). «Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis.». J. Neuropathol. Exp. Neurol. 63 (8): 831–40. PMID 15330338
Gerhard DS, Wagner L, Feingold EA; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
{{citar periódico|autor =Cube RV, Vernier JM, Hutchinson JH, et al. |título=3-(2-Ethoxy-4-{3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2) |periódico=Bioorg. Med. Chem. Lett. |volume=15 |número= 9 |páginas= 2389–93 |ano= 2005 |pmid= 15837331 |doi= 10.1016/j.bmcl.2005.02.078 }}
Rodd ZA, McKinzie DL, Bell RL; et al. (2006). «The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats.». Behav. Brain Res. 171 (2): 207–15. PMID 16678921. doi:10.1016/j.bbr.2006.03.032

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[1] Chad J. Swanson, Mark Bures, Michael P. Johnson, Anni-Maija Linden, James A. Monn & Darryle D. Schoepp. «Metabotropic glutamate receptors as novel targets for anxiety and stress disorders» (em inglês). fevereiro de 2005. Consultado em 1 de julho de 2010

[pmid7620613-2] Flor PJ, Lindauer K, Puttner I, Ruegg D, Lukic S, Knopfel T, Kuhn R (1995). «Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2». Eur J Neurosci. 7 (4): 622–9. PMID 7620613. doi:10.1111/j.1460-9568.1995.tb00666.x

[entrez-3] «Entrez Gene: GRM2 glutamate receptor, metabotropic 2»

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